Results 101 to 110 of about 746,766 (243)

The Interferon-Gamma Paradox in Cancer [PDF]

Journal of Interferon & Cytokine Research, 2019
Interferon-gamma (IFNG) has long been implicated as a central orchestrator of antitumor immune responses in the elimination stage of the immunoediting paradigm. However, mounting evidence suggests that IFNG may also have important and significant protumor roles to play in the equilibrium and escape phases through its regulatory effects on immunoevasive
openaire   +2 more sources

Arrayed Magnetic Accelerator Synergistically Enhances Orthodontic Tooth Movement via Microtubule Assembly‐Mediated Periodontal Remodeling

Advanced Science, EarlyView.
Mechanical orthodontic treatment for malocclusion is limited by slow remodeling and risks due to poor biomechanical sensing. This study shows that static magnetic fields (SMFs) enhance mechanical sensation in periodontal ligament cells, promoting inflammation and osteoclast activity.
Yiling Lou, Jiwei Sun, Peng Chen, Caihong Mao, Junyuan Zhang, Haoqi Lei, Xiaoqing Han, Yaxuan Zhang, Yuheng Jiang, Yulin Jia, Bin Su, Lili Chen   +11 more
wiley   +1 more source

Immunotherapy of murine visceral leishmaniasis with murine recombinant interferon gamma and MTP-PE encapsulated in liposomes

, 2022
S.177-185The efficiency of immunotherapy with murine recombinant interferon-Gamma (rIFN-Gamma) in mouse visceral leishmaniasis caused by Leishmania donovani was examined.
Paulini, I., Franke, G., Lohmann-Matthes, M.-L., Hockertz, S.   +3 more
core   +1 more source

Predicting Single‐Cell Perturbation Responses Across Biological Contexts With a Deep Generative Model Integrating Optimal Transport

Advanced Science, EarlyView.
Single‐cell perturbation responses are predicted across held‐out biological contexts using scPILOT, a query‐conditioned two‐stage latent response‐transfer framework. A shared latent representation supports cell‐level response estimation by latent optimal transport, followed by Leiden‐localized query‐specific transfer and adaptive weighting.
Jialiang Wang, Ziqi Liu, Zhengqian Zhang, Yikun Cao, Junjun Ren, Peng Cheng, Jingjing Tian, Lingyun Xie, Xin Lu, Zhanwei Du, Yongzhuang Liu   +10 more
wiley   +1 more source

Tumor-intrinsic IFNγ signaling and niche adaptation drive early colonization in ovarian cancer metastasis

Nature Communications
The mechanisms enabling disseminating tumor cells to survive and colonize peritoneal niches during ovarian cancer metastasis remain incompletely understood.
Emilija Aleksandrovic, Shaneann R. Fross, Samantha M. Golomb, Wei Ma, Xiyu Liu, Zhuo Zhao, Nikitha M. Das, Tanner C. Reese, Hazel M. Borges, Ates Tenekeci, Lei Yu, Jacqueline Lopez, Min Zhao, Zhenyu Zhong, Kevin M. Dean, Jayanthi Lea, Lin Xu, M. Sharon Stack, Siyuan Zhang   +18 more
doaj   +1 more source

Immune Stimulation of Interferon-Gamma- and Biopterin Synthesis with Endotoxin in Animal-Experimental Peritonitis

Pteridines, 1993
As a result to a microhial stimulus different defence systems are activated. Bacterial lipopolysaccharids (endotoxins) can lead to activation of the immune system in which phagocytic cells like macrophages.
Kullich W., Weissenhofer W., Hunsicker A., Rokos H.   +3 more
doaj   +1 more source

Interferon Gamma: Friend or Foe?

Transplantation, 2007
Interferon gamma (IFN-gamma) can elicit an inflammatory TH1-driven immune response but has also been found to be necessary for long-term allograft survival induced by costimulation blockade. Recently, we have found that regulatory T cells rapidly and transiently produce IFN-gamma creating a microenvironment that can influence the function of antigen ...
Wood, K, Feng, G, Wei, B, Sawitzki, B, Bushell, A   +4 more
openaire   +3 more sources

Interferon-gamma levels in familial Mediterranean fever

, 2005
Aims. - To evaluate the levels of endogenous interferon-gamma (IFN-gamma) in patients with familial Mediterranean fever (FMF)
Ertenli, I, Ozturk, MA, Koklu, S, Yuksel, O, Balci, M, Kiraz, S   +5 more
core   +1 more source

An Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions

Advanced Science, EarlyView.
The injectable CeTA@GPP hydrogel is administered via intrauterine injection, forming a protective barrier. In the high ROS inflammatory microenvironment of injured endometrium, boronate ester cleavage triggers responsive CeTA release and local enrichment.
Peixian Cheng, Jian Song, Yuxin Li, Ming Chen, Zeshen Liang, Binyao Qiu, Xuemin Liu, Xuetao Shi, Yong Fan   +8 more
wiley   +1 more source

Complexity of interferon gamma interactions with HSV-1

Frontiers in Immunology, 2014
The intricacies involving herpesvirus persistence are complex. Herpes simplex virus type 1 (HSV-1) uses a variety of receptors to enter cells, and is transported to and from the host cell nucleus over the microtubule railroad via retrograde and ...
Nancy Jane Bigley
doaj   +1 more source