Results 31 to 40 of about 35,670 (265)

Tuberculin skin test – Outdated or still useful for Latent TB infection screening?

International Journal of Infectious Diseases, 2019
Objective: To make an informed viewpoint on the usefulness of Tuberculin Skin test (TST) compared to Interferon Gamma Release Assays (IGRAs) for diagnosis of Latent TB Infection (LTBI) in different geographical settings.
Gina Gualano, Paola Mencarini, Francesco Nicola Lauria, Fabrizio Palmieri, Sayoki Mfinanga, Peter Mwaba, Jeremiah Chakaya, Alimuddin Zumla, Giuseppe Ippolito   +8 more
doaj   +1 more source

Intraocular Tuberculosis: A Challenging Case Mimicking Wet Age-Related Macular Degeneration

Case Reports in Ophthalmology, 2021
An otherwise healthy 72-year-old Chinese patient diagnosed with exudative age-related macular degeneration and decreased vision in left eye was fully investigated.
Emanuela Interlandi, Francesco Pellegrini, Carlos Pavesio, Marco De Luca, Rocco De Marco, Alessandro Papayannis, Erika Mandarà, Alessandra Cuna, Daniele Cirone, Cristina Ciabattoni, Tatiana Liberali, Antonio Zappacosta, Loredana Latanza   +12 more
doaj   +1 more source

Hemodialysis acutely altered interferon-gamma release assay test result and immune cell profile

Journal of Microbiology, Immunology and Infection, 2022
Patients receiving hemodialysis (HD) are at risk of TB development. IGRA-positive patients showed significant decrease in quantitative IGRA result with alterations in CD3+CD4+CD45RO+, NK cell, and monocyte subsets immediately upon HD procedure. Our result suggested that the timing of IGRA testing is crucial in end-stage renal disease population.
Denise Utami Putri, Chia-Ling Chen, Cheng-Hui Wang, Yuh-Mou Sue, Po-Chun Tseng, Chiou-Feng Lin, Ching-Wen Tsai, Yi-Jun Liu, Chih-Hsin Lee   +8 more
openaire   +3 more sources

Interferon-gamma-release assays: Better than tuberculin skin testing?

Cleveland Clinic Journal of Medicine, 2010
Although the tuberculin skin test has long been the standard for detecting latent tuberculosis infection, it has many limitations. Interferon-gamma-release assays are gaining acceptance as an alternative. In this paper we present cases to illustrate how these new tests can be used and how to interpret the results.
Cyndee, Miranda, J Walton, Tomford, Steven M, Gordon   +2 more
openaire   +2 more sources

[Concordance of tuberculin tests and Interferon gamma release assays in the prison population].

Revista espanola de sanidad penitenciaria, 2011
To study the agreement of Tuberculin Skin Tests (TST) and Interferon Gamma Release Assays (IGRA) when screening tuberculosis infection amongst inmates recently admitted to prison.Prospective study conducted in a prison during the months of May and June 2009.
A, Marco Mouriño, A, Orcau Palau, R, Jané Galliga, M, Escribano Ibáñez, J A, Caylà Buqueras, N, Solé Zapata, L, del Baño Hollín, S, Quintero del Río, M D, Ferrer Escobar, J, Mangues Bafalluy, R A, Guerrero Moreno, V, Martín Sánchez   +11 more
openaire   +2 more sources

Interferon-gamma release assays for the tuberculosis serial testing of health care workers: a systematic review [PDF]

Journal of Occupational Medicine and Toxicology, 2012
Interferon-gamma release assays (IGRAs) are increasingly used in the tuberculosis (TB) screening of health care workers (HCWs). However, comparatively high rates of conversions and reversion as well as growing evidence of substantial within-subject variability of interferon-gamma responses complicate their interpretation in the serial testing of HCWs ...
Ringshausen Felix C, Schablon Anja, Nienhaus Albert   +2 more
openaire   +3 more sources

Interferon Gamma Release Assay Compared With the Tuberculin Skin Test for Latent Tuberculosis Detection in Pregnancy [PDF]

Obstetrics & Gynecology, 2011
To estimate agreement and correlation between the tuberculin skin test and an interferon gamma release assay for detecting latent tuberculosis (TB) infection in pregnant women.We conducted a cross-sectional study of pregnant women initiating prenatal care at a university-affiliated public hospital between January 5, 2009, and March 15, 2010.
Ayaba, Worjoloh, Midori, Kato-Maeda, Dennis, Osmond, Rachel, Freyre, Natali, Aziz, Deborah, Cohan   +5 more
openaire   +2 more sources

Tuberculin Test versus Interferon Gamma Release Assay in Pregnant Women with Household Contacts of Tuberculosis Patients

The International Journal of Mycobacteriology, 2022
Background: Pregnant women who live in tuberculosis (TB)-affected households are more likely to develop latent TB infection (LTBI), which often escapes treatment. This study aims to determine if Interferon-gamma release (IGRA) is reliable in screening for LTBI in pregnant women, compare to the tuberculin skin test (TST).
Maisuri Tadjuddin Chalid, Dian Puspawaty, Andi Mardiah Tahir, Hidayah Najdah, Muhammad Nasrum Massi   +4 more
openaire   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source