Results 51 to 60 of about 58,702 (314)

Interferon gamma release assays for Diagnostic Evaluation of Active tuberculosis (IDEA): test accuracy study and economic evaluation.

Health Technology Assessment, 2019
BACKGROUND Interferon gamma release assays (IGRAs) are blood tests recommended for the diagnosis of tuberculosis (TB) infection. There is currently uncertainty about the role and clinical utility of IGRAs in the diagnostic workup of suspected active TB ...
Y. Takwoingi, H. Whitworth, M. Rees-Roberts, Amarjit Badhan, Christopher Partlett, N. Green, A. Boakye, Heather Lambie, L. Marongiu, M. Jit, P. White, J. Deeks, O. Kon, A. Lalvani   +13 more
semanticscholar   +1 more source

Interferon Gamma Release Assay Compared With the Tuberculin Skin Test for Latent Tuberculosis Detection in Pregnancy [PDF]

Obstetrics & Gynecology, 2011
To estimate agreement and correlation between the tuberculin skin test and an interferon gamma release assay for detecting latent tuberculosis (TB) infection in pregnant women.We conducted a cross-sectional study of pregnant women initiating prenatal care at a university-affiliated public hospital between January 5, 2009, and March 15, 2010.
Ayaba, Worjoloh, Midori, Kato-Maeda, Dennis, Osmond, Rachel, Freyre, Natali, Aziz, Deborah, Cohan   +5 more
openaire   +2 more sources

Tuberculin Test versus Interferon Gamma Release Assay in Pregnant Women with Household Contacts of Tuberculosis Patients

The International Journal of Mycobacteriology, 2022
Background: Pregnant women who live in tuberculosis (TB)-affected households are more likely to develop latent TB infection (LTBI), which often escapes treatment. This study aims to determine if Interferon-gamma release (IGRA) is reliable in screening for LTBI in pregnant women, compare to the tuberculin skin test (TST).
Maisuri Tadjuddin Chalid, Dian Puspawaty, Andi Mardiah Tahir, Hidayah Najdah, Muhammad Nasrum Massi   +4 more
openaire   +3 more sources

Validation and Clinical Application of Interferon-Gamma Release Assay for Diagnosis of Latent Tuberculosis Infection in Children

International Journal of Applied and Basic Medical Research, 2019
Background: India has the highest tuberculosis (TB) burden, accounting for one-fifth of the global incidence and two-third of the cases in Southeast Asia with an estimated 1.9 million new cases every year.
K. Benachinmardi, S. Sangeetha, M. Rao, R. Prema   +3 more
semanticscholar   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Interferon gamma-induced protein-10 concentrations in children with previous tuberculosis infections and disease

, 2012
Interferon gamma-induced protein-10 is a diagnostic test for tuberculosis infection. There is no information on its concentrations over time. Interferon gamma-induced protein-10 was evaluated in 72 children formerly treated or in former contact with ...
Alves, Gerlane, Cuevas, Luis E., Souza, Edvaldo, Correia, Jailson B., Cavalcanti, Nara, Bihari, Smiti, Brabin, Bernard J., Cuevas, Luis   +7 more
core   +1 more source

Interferon-gamma release assay for the diagnosis of latent tuberculosis infection: A latent-class analysis

PLoS ONE, 2017
Background Accurate diagnosis and subsequent treatment of latent tuberculosis infection (LTBI) is essential for TB elimination. However, the absence of a gold standard test for diagnosing LTBI makes assessment of the true prevalence of LTBI and the ...
T. Doan, D. Eisen, M. Rose, A. Slack, G. Stearnes, E. McBryde   +5 more
semanticscholar   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Progress in interferon-gamma release assay development and applications: an unfolding story of translational research.

Annals of Translational Medicine, 2019
The introduction of blood-based tests for M. tuberculosis ( Mtb ) infection approximately 15 years ago was a turning point for diagnosis of latent tuberculosis (TB).
A. Lalvani, H. Whitworth
semanticscholar   +1 more source