Results 101 to 110 of about 1,191,146 (396)

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins

Viruses, 2018
Influenza A viruses (IAV) can infect a broad range of animal hosts, including humans. In humans, IAV causes seasonal annual epidemics and occasional pandemics, representing a serious public health and economic problem, which is most effectively prevented
Aitor Nogales, Luis Martinez-Sobrido, David J. Topham, Marta L. DeDiego   +3 more
doaj   +1 more source

The Effect of Interferon, Interferon Inducers or Interferon Induced Virus Resistance on Subsequent Interferon Production

Journal of General Virology, 1972
Summary The pre-treatment of mouse L cells with interferon or polyinosinic-polycytidylic acid potentiated the interferon response of these cells to subsequent stimulation with suboptimal doses of polyinosinic-polycytidylic acid. This potentiation was manifested as an earlier production of interferon, a faster attainment of maximum interferon production,
H. B. Levy, S. A. Margolis, H. Oie
openaire   +3 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Modeling Arboviral Infection in Mice Lacking the Interferon Alpha/Beta Receptor

Viruses, 2019
Arboviruses are arthropod-borne viruses that exhibit worldwide distribution and are a constant threat, not only for public health but also for wildlife, domestic animals, and even plants.
Alejandro Marín-Lopez, Eva Calvo-Pinilla, Sandra Moreno, Sergio Utrilla-Trigo, Aitor Nogales, Alejandro Brun, Erol Fikrig, Javier Ortego   +7 more
doaj   +1 more source

Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood

Journal of Experimental Medicine, 2003
Systemic lupus erythematosus (SLE) is a prototype systemic autoimmune disease characterized by flares of high morbidity. Using oligonucleotide microarrays, we now show that active SLE can be distinguished by a remarkably homogeneous gene expression ...
Lynda Bennett, A. Palucka, E. Arce, E. Arce, Victoria Cantrell, Victoria Cantrell, J. Borvák, J. Banchereau, V. Pascual, V. Pascual   +9 more
semanticscholar   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Functionally impaired plasmacytoid dendritic cells and non-haematopoietic sources of type I interferon characterize human autoimmunity

Nature Communications, 2020
Autoimmune connective tissue diseases arise in a stepwise fashion from asymptomatic preclinical autoimmunity. Type I interferons have a crucial role in the progression to established autoimmune diseases.
A. Psarras, A. Alase, A. Antanaviciute, I. Carr, Md Yuzaiful Md Yusof, M. Wittmann, P. Emery, G. Tsokos, E. Vital   +8 more
semanticscholar   +1 more source

Type I interferons in tuberculosis: Foe and occasionally friend [PDF]

, 2018
Tuberculosis remains one of the leading causes of mortality worldwide, and, despite its clinical significance, there are still significant gaps in our understanding of pathogenic and protective mechanisms triggered by Mycobacterium tuberculosis infection.
Mayer-Barber, K, Moreira-Teixeira, L, O'Garra, A, Sher, A   +3 more
core   +1 more source

Interferon in the CNS

Neurosignals, 2019
While the role of interferon during systemic disease is well known and its immune modulating functions and its role in antiviral activity were extensively studied, the role of IFN-I in the brain is less clear. Here we summarize the most important literature on IFN in homeostasis of the CNS and induction of an IFN response during viral infection in the ...
Bhat, Hilal, Lang, Karl S., Hardt, Cornelia, Lang, Judith   +3 more
openaire   +4 more sources