Results 231 to 240 of about 25,282,834 (298)

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Innate Immune Cells in Non-Small Cell Lung Cancer: Roles in Tumor Progression and Therapeutic Responses. [PDF]

Cancer Innov
Liu J, Jia J, Wang C, Zhou Z, Cheng Z, Zhang Z, Jiang X, Huang Z, Li C.   +8 more
europepmc   +1 more source

Chronic interferon signaling at baseline is associated with acquired resistance to immunotherapy in metastatic melanoma. [PDF]

Cell Rep Med
Egan D, Shum B, Fidan R, Kolch W, Brennan D, Lobon I, Turajlic S.   +6 more
europepmc   +1 more source

The Pharmacology of the SLC15A4-TASL Complex, an Emerging Target for the Treatment of Lupus. [PDF]

Pharmacol Res Perspect
Wilkinson AL, Popat D, Sengmany K, Silva MC, Charlton SJ, Lay CS.   +5 more
europepmc   +1 more source

KRAS inhibition is an effective therapy for appendiceal adenocarcinoma. [PDF]

J Hematol Oncol
Chowdhury S, Ito I, Pattalachinti VK, Yousef AMG, Yousef MMG, El Khoury S, Hornstein N, Seldomridge AN, Hong D, Overman MJ, Taggart MW, Foo WC, Helmink B, Fournier KF, Shen JP.   +14 more
europepmc   +1 more source

Rapid clearance of facial verruca plana with local hyperthermia treatment combined with topical interferon alpha-2b in 3 weeks: a case report. [PDF]

J Med Case Rep
Liu F, Qi RQ, Niu X, Wan W.
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient-derived model of high-grade serous ovarian cancer. [PDF]

Mol Oncol
Conant A, Suzuki T, McGivney K, Ayyadevara VSSA, Asariah S, Deng J, Nyein E, Coats J, Yu G, Ioffe YJ, Hurtz C, Unternaehrer JJ.   +11 more
europepmc   +1 more source

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Immunochemical mapping of .alpha.-2 interferon

Biochemistry, 1985
A panel of five monoclonal antibodies, designated U1-U5, produced by murine hybridoma clones has been raised to recombinant interferon (IFN) alpha-2, and one monoclonal antibody, designated U6, has been raised to a mixture of cyanogen bromide fragments of IFN alpha-2.
N B, Lydon, C, Favre, S, Bove, O, Neyret, S, Benureau, A M, Levine, G F, Seelig, T L, Nagabhushan, P P, Trotta   +8 more
openaire   +2 more sources

Interferon-alpha-2 in the treatment of idiopathic myelofibrosis

Blut, 1988
We investigated the effect of human recombinant DNA-derived IFN-alpha-2 given in a dose of 1-2 X 10(6) units daily by subcutaneous injection to five patients with advanced idiopathic myelofibrosis (IM). Transfusion dependent anemia and symptomatic splenomegaly were taken as inclusion criteria for this pilot study.
H L, Seewann, G, Gastl, A, Lang, K, Abbrederis, J, Thaler, R, Flener, C, Huber   +6 more
openaire   +2 more sources