Results 241 to 250 of about 25,282,834 (298)

Interleukin-2 and interferon alpha 2 combination

Oncology Reports, 1996
We have studied activity and toxicity of subcutaneous recombinant interleukin-2 and interferon alpha 2b in a series of 14 patients with advanced renal cell carcinoma. No objective response was observed, and the median survival was 16 months (range 3-19); toxicity was acceptable.
P, Pronzato, A, Vigani, F, Vaira, F, Tani, M, Vanoli   +4 more
openaire   +2 more sources

New Combined Eye Gel with Alpha-2-Beta Interferon

Bulletin of Experimental Biology and Medicine, 2020
The results of the development of combined eye gel with interferon alpha-2-beta are presented. Experimental samples of the gel based on different gelling agents were prepared and their biotechnological and technological characteristics (the absence of the cytotoxic effect, aggregation stability, osmotic activity, bioadhesion, and rheological parameters)
M N, Anurova, E O, Bakhrushina, I V, Lapik, A S, Kashperko, I I, Krasnyuk   +4 more
openaire   +2 more sources

Induction of acute corneal allograft rejection by alpha-2 interferon

The American Journal of Medicine, 1987
A 38-year-old man who underwent corneal transplantation in 1973 for treatment of a keratoconus is described. In 1982, hairy cell leukemia was diagnosed and he was treated with splenectomy followed by chlorambucil and androgen therapy. In April 1984, treatment with alpha-2 interferon was begun, and two weeks later, evidence of acute corneal allograft ...
A D, Jacobs, J E, Levenson, D W, Golde
openaire   +2 more sources

Hairy cell leukemia and mucormycosis. Treatment with alpha-2 interferon

The American Journal of Medicine, 1986
Right maxillary sinus mucormycosis developed in a 45-year-old patient with hairy cell leukemia and pancytopenia. The patient recovered with surgical debridement, amphotericin therapy, and institution of alpha-2 interferon as therapy for his hairy cell leukemia.
C L, Bennett, C A, Westbrook, B, Gruber, H M, Golomb   +3 more
openaire   +2 more sources

Interferon alpha-2 enhances slow-wave sleep in rabbits

International Journal of Immunopharmacology, 1987
Interferon alpha-2 (IFN) is a leukocyte product with several biological properties including antiviral activity, pyrogenicity and enhancement of immune functions. We report here that an additional facet of IFN activity is its ability to enhance slow-wave sleep (SWS) without greatly altering other aspects of sleep.
J M, Krueger, C A, Dinarello, S, Shoham, D, Davenne, J, Walter, S, Kubillus   +5 more
openaire   +2 more sources

Alpha-2 Interferon and 5-Fluorouracil in Advanced Colorectal Cancer

Tumori Journal, 1990
A total of 21 untreated patients (5 males, 16 females; median age, 55 years; range, 28-72) with advanced measurable colorectal carcinoma were treated with an association of 5-fluoro-uracil (1000 mg/weekly) and alpha-2 interferon (three times a week s.c.: 6×10 6 U in the 1st month, 9×10
A, Fornasiero, O, Daniele, C, Ghiotto, S M, Aversa, P, Morandi, M V, Fiorentino   +5 more
openaire   +2 more sources

Antibodies to interferon-alpha 2 in patients treated with interferon-alpha 2 for hairy cell leukemia.

Journal of interferon research, 1989
Some patients treated with interferon (IFN) have developed antibodies (ABs) to that IFN. We examined the incidence of such ABs in hairy cell leukemia (HCL) patients treated with IFN-alpha 2a and IFN-alpha 2b. In the initial enzyme-linked immunosorbent assay (ELISA) assays, the serum samples were tested against their corresponding IFNs.
J B, Bekisz, D L, zur Nedden, J C, Enterline, K C, Zoon   +3 more
openaire   +1 more source

Porcine leukocyte interferon exhibits close antigenic relatedness to human interferon alpha 2, but not to human interferon alpha 1

Veterinary Immunology and Immunopathology, 1993
As reported by others using polyclonal antisera, natural human and porcine interferons (IFN)-alpha are antigenically related. Using monoclonal antibodies (mAb) in neutralization and ELISA experiments, we found differences in the subtype/antigenic composition between virus-induced porcine and human leukocyte preparations.
G, Karayianni-Vasconcelos, L, Borecký, P, Kontsek   +2 more
openaire   +2 more sources

Recombinant alpha2 interferon-related cardiomyopathy

The American Journal of Medicine, 1988
I nterferons are naturally occurring proteins with antiviral, antitumor, and immune-modulating activities. Three groups of interferons have been identified: alpha interferon, derived from leukocytes; beta interferon, from fibroblasts, and most recently, gamma interferon, which is derived from lymphocytes.
M C, Cohen, M S, Huberman, R W, Nesto
openaire   +2 more sources

Cortisol stimulation by recombinant interferon-α2

Journal of Neuroimmunology, 1986
Serum cortisol concentrations were determined by radioimmunoassay in cancer patients undergoing experimental therapy with recombinant interferon-alpha 2. Cortisol concentration rose steadily after interferon administration and was significantly different from that on control day at 8 h following intramuscular injection of interferon-alpha 2.
J, Roosth, R B, Pollard, S L, Brown, W J, Meyer   +3 more
openaire   +2 more sources