Results 51 to 60 of about 236,667 (309)

Chickenpox in Children: Features of Treatment

Zdorovʹe Rebenka, 2014
We observed 96 children with chickenpox aged from 2 weeks to 17 years. These patients had violations of interferon and cytokine status. Inclusion of Laferobionum into complex of treatment for chickenpox in children contributes to a more rapid involution ...
S.A. Kramarev, O.V. Vygovskaya, V.V. Deyev, A.P. Moshich, O.F. Melnikov, A.V. Shashkina, Yu.Ye. Nadvorskaya, O.S. Pilipenko, T.A. Kolinko, U. Godvin   +9 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Obtaining the transgenic hairy root culture of topinambour (Helianthus tuberosus L.) containing hu-man interferon alpha-2b gene

Фактори експериментальної еволюції організмів, 2013
The aim of the study was to obtain Helianthus tuberosus L. hairy root culture containing human interferon alpha gene driven by constitutive 35S CaMV and root specific Mll sugar beet promoters by means of Agrobacterium rhizogenes-mediated transformation.
O. M. Maistrenko, Yu. S. Luchakivska
doaj  

Clinical outcomes of different therapeutic options for COVID-19 in two Chinese case cohorts: A propensity-score analysis

EClinicalMedicine, 2021
Background: The timing of administration of agents and use of combination treatments in COVID-19 remain unclear. We assessed the effectiveness of therapeutics in cohorts in Hong Kong SAR and Anhui, China.
Carlos K.H. Wong, Eric Y.F. Wan, Sihui Luo, Yu Ding, Eric H.Y. Lau, Ping Ling, Xiaowen Hu, Edward C.H. Lau, Jerry Wong, Xueying Zheng, Benjamin J. Cowling, Jianping Weng, Gabriel M. Leung   +12 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Cost-effectiveness of pegylated interferon and ribavirin for patients with chronic hepatitis C treated in routine clinical practice. [PDF]

, 2009
OBJECTIVES: This study assesses whether pegylated interferon and ribavirin is cost-effective compared with no antiviral treatment provided in routine clinical practice, for different patient subgroups.
Grishchenko, Marina, Sweeting, Michael J, Thomson, Brian J, Irving, William L, Ryder, Stephen D, Grieve, Richard D, Trent HCV Study Group, De Angelis, Daniela   +7 more
core   +1 more source

Discovery of a signaling feedback circuit that defines interferon responses in myeloproliferative neoplasms

Nature Communications, 2022
Interferon alpha (IFNalpha) therapy is showing promising results to treat myeloproliferative neoplasms (MPNs). Here, the authors show that IFNalpha response requires ULK1 phosphorylation to induce p38-MAPK signalling but it is counteracted by ROCK1-2 ...
Diana Saleiro, Jeremy Q. Wen, Ewa M. Kosciuczuk, Frank Eckerdt, Elspeth M. Beauchamp, Chidera V. Oku, Gavin T. Blyth, Mariafausta Fischietti, Liliana Ilut, Marco Colamonici, William Palivos, Paula A. Atsaves, Dean Tan, Masha Kocherginsky, Rona Singer Weinberg, Eleanor N. Fish, John D. Crispino, Ronald Hoffman, Leonidas C. Platanias   +18 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Are anti-interferon antibodies the cause of failure in: chronic HCV hepatitis treatment?

Brazilian Journal of Infectious Diseases
A follow-up study was made of 94 chronic hepatitis C patients at a hepatitis clinic in Brazil, after interferon alpha (IFN-alpha) therapy, to determine the influence of anti-interferon antibodies on treatment outcome. Patients diagnosed as having chronic
Antonio Alci Barone, Rose Aparecida Borges Tosta, Fátima Mitiko Tengan, José Humberto Caetano Marins, Norma de Paula Cavalheiro, Bruno Andrade Cardi   +5 more
doaj   +1 more source

Treatment of Metastatic Malignant Melanoma with Recombinant Interferon Alpha 2

Immunobiology, 1986
Fifty-nine patients with metastatic malignant melanoma were entered into a phase II trial of recombinant alpha-2 interferon given in a dosage of 10 million IU/M2 subcutaneously three times per week for one year. Forty-five of these were evaluable for response.
W A, Robinson, T I, Mughal, M R, Thomas, M, Johnson, R J, Spiegel   +4 more
openaire   +2 more sources