Results 51 to 60 of about 25,282,834 (298)

Evaluation of the effectiveness of antiviral therapy for coronavirus infection (COVID-19) with the inclusion of recombinant interferon alpha-2b

Лечащий Врач, 2022
A prospective comparative controlled study included 100 patients with a confirmed diagnosis of COVID-19 coronavirus infection, randomized into two groups: the main group (MG) – 50 patients receiving interferon alpha-2b preparations, rectal suppositories ...
A. V. Mordyk, O. G. Ivanova, K. Yu. Samsonov, S. V. Sitnikova, A. N. Shuvalov, O. V. Parshina, T. S. Guseva   +6 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Serum S100B in primary progressive multiple sclerosis patients treated with interferon-beta-1a. [PDF]

, 2004
S100B belongs to a family of calcium-binding proteins implicated in intracellular and extracellular regulatory activities. This study of serum S100B in primary progressive multiple sclerosis (PPMS) is based on data obtained from a randomized, controlled ...
Lim, Ee Tuan, Leary, Siobhan M, Geoff Keir, Petzold, Axel, Thompson, Alan J, Gavin Giovannoni, Siobhan M Leary, Altmann, Daniel R, Keir, Geoff, Ee Tuan Lim, David H Miller, Ed J Thompson, Giovannoni, Gavin, Miller, David H, Alan J Thompson, Daniel R Altmann, Thompson, Ed J, Axel Petzold   +17 more
core   +2 more sources

Update of interferon use in acute simple bronchitis in children

Zdorovʹe Rebenka, 2018
Background. The main etiological factors of acute simple bronchitis in children are respiratory viruses, and therefore interferon preparations can be used in the treatment of these respiratory diseases.
A.E. Abaturov, N.M. Tokarieva
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Interferon, virus vaccines and antiviral drugs [PDF]

, 2008
The emergence of viruses with zoonotic potential, i.e. with the potential ability to cross species barriers to infect unnatural hosts, poses a huge threat to humans.
Rodrigues, Ana Mara Lopes
core   +2 more sources

Obtaining the transgenic hairy root culture of topinambour (Helianthus tuberosus L.) containing hu-man interferon alpha-2b gene

Фактори експериментальної еволюції організмів, 2013
The aim of the study was to obtain Helianthus tuberosus L. hairy root culture containing human interferon alpha gene driven by constitutive 35S CaMV and root specific Mll sugar beet promoters by means of Agrobacterium rhizogenes-mediated transformation.
O. M. Maistrenko, Yu. S. Luchakivska
doaj  

Treatment of Metastatic Malignant Melanoma with Recombinant Interferon Alpha 2

Immunobiology, 1986
Fifty-nine patients with metastatic malignant melanoma were entered into a phase II trial of recombinant alpha-2 interferon given in a dosage of 10 million IU/M2 subcutaneously three times per week for one year. Forty-five of these were evaluable for response.
W A, Robinson, T I, Mughal, M R, Thomas, M, Johnson, R J, Spiegel   +4 more
openaire   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Omalizumab may protect allergic patients against COVID-19: A systematic review

World Allergy Organization Journal, 2023
Omalizumab, which downregulates the immunoglobulin E (IgE) receptor site on plasmacytoid dendritic cells and thereby increases interferon-α (INF-α) production, may shorten the duration of viral infections by enhancing the antiviral immunity.A systematic ...
Daniele Giovanni Ghiglioni, MD, ET Laura Cozzi, MD, Riccardo Castagnoli, MD, PhD, Gaia Bruschi, MD, Laura Maffeis, MD, Paola Giovanna Marchisio, MD, Gian Luigi Marseglia, MD, Amelia Licari, MD, PhD   +7 more
doaj   +1 more source