Results 41 to 50 of about 25,282,834 (298)

FREQUENCY OF SIDE EFFECTS OF ANTIVIRUS THERAPY FOR CHRONIC VIRUS HEPATITIS IN CHILDHOOD

Педиатрическая фармакология, 2010
In pediatrics, the issue of using antivirus therapy for chronic virus hepatitis is not sufficiently studied, there is search for rational combinations, schemes, doses and length of treatment. The article demonstrates results of using a combined antivirus
S.V. Romanova, E.A. Zhukova, N.A. Kaplina, L.V. Korkotashvili, I.V. Mayanskaya, M.V. Groshovkina, I.A. Timchenko   +6 more
doaj   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Increased interferon alpha receptor 2 mRNA levels is associated with renal cell carcinoma metastasis

BMC Cancer, 2007
Background Interferon-α (IFN-α) is one of the central agents in immunotherapy for renal cell carcinoma (RCC) and binds to the IFN-α receptor (IFNAR). We investigated the role of IFNAR in RCC.
Yamanishi Tomonori, Abe Hideyuki, Arai Kyoko, Yanai Yoshiaki, Kamai Takao, Kurimoto Masashi, Yoshida Ken-Ichiro   +6 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Liver-Targeting of Interferon-Alpha with Tissue-Specific Domain Antibodies [PDF]

, 2013
PMCID: PMC3581439This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Ovecka, M, Coulstock, E, Sepp Armin, Foster, J, Sepp, A, Edward Coulstock (381775), Jerome Burnet (381784), Burnet Jerome, Goodall Laura, Mudd, C, Edward Coulstock, Jane Sosabowski (381776), Mudd Clare, Davies, M, Clare Mudd (381780), Marie Davies, Sosabowski, J, Armin Sepp, Sosabowski Jane, Ovečka Milan, Dunlevy, G, Laura Goodall, Jerome Burnet, Coulstock Edward, Milan Ovečka, Dunlevy Gráinne, Gráinne Dunlevy, Julie Foster, Prince Rob, Foster Julie, Rob Prince, Clare Mudd, Rob Prince (381778), Laura Goodall (381779), Julie Foster (381783), Walker Adam, Goodall, L, Adam Walker, Gráinne Dunlevy (381785), Marie Davies (381782), Adam Walker (381786), Davies Marie, Armin Sepp (381781), Burnet, J, Prince, R, Walker, A, Jane Sosabowski, Milan Ovečka (381777)   +47 more
core   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Viferon Suppositoria in Therapy of Relapsing Herpesvirus Infection in Women

Антибиотики и Химиотерапия, 2020
The therapeutic efficacy of Viferon, a recombinant human interferon alpha-2b (rectal suppositoria) was studied in the therapy of relapsing herpesvirus infection in women. The clinical efficacy of the drug was recorded in 90% of the patients. The analysis
A. N. Vasilyev, ZN. A. Kagramanova, V. V. Malinovskaya, V. V. Parfenov   +3 more
doaj  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The efficacy of intravitreal interferon alpha-2b for the treatment of experimental endotoxin-induced uveitis

Indian Journal of Ophthalmology, 2016
Purpose: To study the efficacy of intravitreal interferon alpha-2b for endotoxin-induced uveitis. Materials and Methods: A total of 36 rabbits were randomly allocated to one of the three groups: (1) received interferon plus balanced-salt solution; (2 ...
Mehrdad Afarid, Hamid Lashkarizadeh, Mohammad J Ashraf, Mohammad Hossein Nowroozzadeh, Sayed M Shafiee   +4 more
doaj   +1 more source