Results 91 to 100 of about 210,768 (294)

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

Eradicating chronic Hepatitis C Viraemia : lessons learnt during the last decade [PDF]

, 2005
Over the last decade a better understanding of the mechanism for immune disposal of hepatocytes infected with the Hepatitis C virus enabled the design of antiviral regimens with increasing efficacy.
Pullicino, Edgar
core  

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Th1 and Th2 cytokines are elevated in HCV-infected SVR(-) patients treated with interferon-alpha

, 2010
[[abstract]]Interferon-alpha-based treatment is a standard therapy to cure hepatitis C virus-infected patients. However, the reasons for the failure of interferon-alpha treatment in some patients have not been fully elucidated.
Wan, L (Wan, Lei); Kung, YJ (Kung, Yung-Jen); Lin, YJ (Lin, Ying-Ju); Liao, CC (Liao, Chiu-Chu); Sheu, JJC (Sheu, Jim J. C.); Tsai, YS (Tsai, Yuhsin); Lai, HC (Lai, Hsueh-Chou); Peng, CY (Peng, Cheng-Yuan); Tsai, FJ (Tsai, Fuu-Jen)
core  

Mycobacterial purified protein derivatives stimulate innate immunity: Malawians show enhanced tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses compared to those of adolescents in the United Kingdom. [PDF]

, 2004
To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom, we examined 24-h tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses to mycobacterial ...
Elizabeth King, King, Elizabeth, Jarman, Elizabeth, Hazel M. Dockrell, Lifted Sichali, Fine, Paul E.M., Blackwell, Jenefer M., Weir, Rosemary E., Elizabeth Jarman, Sally Stenson, Nazareth, Bernadette, Warndorff, David K., Crampin, Amelia C, Black, Gillian F, Stenson, Sally, Mwaungulu, Lorren, Amelia C. Crampin, Linda Donovan, Blackwell, Jenefer M, Rosemary E. Weir, Paul E. M. Fine, Sian Floyd, Bernadette Nazareth, Fine, Paul EM, David K. Warndorff, Black, Gillian F., Crampin, Amelia C., Dockrell, Hazel M., Jenefer M. Blackwell, Floyd, Sian, Chaguluka, Steven D, Lorren Mwaungulu, Sichali, Lifted, Donovan, Linda, Steven D. Chaguluka, Warndorff, David K, Weir, Rosemary E, Chaguluka, Steven D., Dockrell, Hazel M, Ngwira, Bagrey, Bagrey Ngwira, Gillian F. Black   +41 more
core   +1 more source

Renal filtration, absorption and catabolism of human alpha interferon

, 1981
The renal handling of human interferon-alpha has been evaluated by using an isolated and perfused rabbit kidney. IFN-alpha disappears from plasma with a t1/2 of 81 min and the fractional turnover rate is 0.84%/min.
Pacini, A., G.P. PESSINA, Muscettola, M., Santiano, M., L. PAULESU, M. SANTIANO, V. BOCCI, A. PACINI, Pessina, G. P., Viano, I., Bocci, V., Ricci, L., M. MUSCETTOLA, I. VIANO   +13 more
core   +2 more sources

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

Advanced Science, EarlyView.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao, Ruqiong Wang, Bo An, Lishuang Qi, Zihan Jing, Xingmei Ren, Yang Zhou, Mingjun Xu, Jiaojiao Li, Jie Liu, Liying Wang, Gang Xu, Rou Li, Dexin Jia, Yan Yu   +14 more
wiley   +1 more source

The human interferon-induced MxA protein inhibits early stages of influenza A virus infection by retaining the incoming viral genome in the cytoplasm

, 2013
The induction of an interferon-induced antiviral state is a powerful cellular response against viral infection that limits viral spread. Here we show that a pre-existing antiviral state inhibits replication of influenza A viruses in human A549 cells by ...
Xiao, Han, Killip, Marian Jane, Killip, Marian J., Stäheli, Peter, Staeheli, Peter, Randall, Richard Edward, Jackson, David   +6 more
core   +1 more source

Obtaining the transgenic hairy root culture of topinambour (Helianthus tuberosus L.) containing hu-man interferon alpha-2b gene

Фактори експериментальної еволюції організмів, 2013
The aim of the study was to obtain Helianthus tuberosus L. hairy root culture containing human interferon alpha gene driven by constitutive 35S CaMV and root specific Mll sugar beet promoters by means of Agrobacterium rhizogenes-mediated transformation.
O. M. Maistrenko, Yu. S. Luchakivska
doaj