Results 31 to 40 of about 346,598 (285)

IFNα-mediated remodeling of endothelial cells in the bone marrow niche

Haematologica, 2017
In the bone marrow, endothelial cells are a major component of the hematopoietic stem cell vascular niche and are a first line of defense against inflammatory stress and infection.
Áine M. Prendergast, Andrea Kuck, Mieke van Essen, Simon Haas, Sandra Blaszkiewicz, Marieke A. G. Essers   +5 more
doaj   +1 more source

Deciphering the role of interferon alpha signaling and microenvironment crosstalk in inflammatory breast cancer

Breast Cancer Research, 2019
Inflammatory breast cancer (IBC) is the most rare and aggressive subtype of breast cancer characterized by clusters of tumor cells invading lymph vessels, high rates of metastasis, and resistance to systemic chemotherapy.
Olivia K. Provance, Joan Lewis-Wambi
doaj   +1 more source

Guidance on noncorticosteroid systemic immunomodulatory therapy in noninfectious uveitis: fundamentals of care for uveitis (focus) initiative [PDF]

, 2018
Topic: An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in the era of biologics.
Acharya, Nisha, Adan, Alfredo, Agrawal, Rupesh, Akkoc, Nurullah, Al Ghamdi, Saed, Al Ghamdi, Turki, Al Saati, Anood, Al-Dhibi, Hassan A., Al-Shamarani, Mohamed, Alsabaani, Nasser, Bachta, Artur, Barisani-Asenbauer, Talin, Beare, Nicholas, Belga Ottoni Porto, Fernanda, Blanco, Ricardo, Brézin, Antoine P., Carreño, Ester, Chan Sook Yee, Anita, Chandran, Vinod, Chiquet, Christophe, Cimbalas, Andrius, Cimino, Luca, Cordero-Coma, Miguel, Correspondence information about the author FMedSci, FRCOphth, Cristobal, Couto, Cuevas, Miguel, Davis, Janet L., de Boer, Joke, de la Torre, Alejandra, De Schryver, Ilse, Derzko-Dzulynsky, Larissa, Diaz-Valle, David, Dick, Andrew D., Dick, FRCOphth Andrew D., Dick†, FRCOphth Andrew D., Eugenia Duran Merino, Claudia, Eurico da Fonseca, João, Facsko, Andrea, Figueira, Luis, FMedSci,, Fonollosa, Alejandro, Fortin, Eric, FRCOphth,, FRCPCH, FRCP, FRCS, FRCOphth, FRCSEd(Ophth), FRCOphth, Gale, Richard, Galeazzi, Mauro, Garcia, Sandra, Gašperšič, Nataša, Goldstein, Debra, Guedes, Marta, Guex-Crosier, Yan, Gul, Ahmet, Hamam, Rola, Haroon, Muhammad, Hasegawa, Kenichi, Hee Chng, Hiok, Heiligenhaus, Arnd, Hisae Yamamoto, Joyce, Hooper, Claire, Hwang, De-Kuang, Hwang, Yih-Shiou, Jr., Rubens Belfort, Juanola, Xavier, Kaburaki, Toshikatsu, Kadayifcilar, Sibel, Kempen, John, Kezuka, Takeshi, Kherani, Amin, Kiak Lim, Wee, Kirsimäe, Maarja, Kotaniemi, Kaisu, Kraut, Aleksandra, Kubicka-Trząska, Agnieszka, Kuffova, Lucia, Lightman, Susan, Lim, Lyndell, MA, MD, Maria Garcia Ruiz de Morales, Jose, Massimo Accorinti, MBChB(Hons), McCluskey, Peter, McGuire, Mairide, MD,, MD,, MD,, MD,, MD†,, Mirabelli, Pierfrancesco, Miserocchi, Elisabetta, Misiuk-Hojło, Marta, Muccioli, Cristina, Murphy, Conor, Murray, Philip I., Muñoz, Santiago, Nagy, Zoltan, Namba, Kenichi, Nascimento, Heloisa, Neri, Piergiorgio, Nguyen, Quan, O'Gradaigh, Donncha, Omair, Mohammed, Otsa, Kati, Ozyazgan, Yilmaz, Pablo, Franco, PAROLI, Maria Pia, Phaik Chee, Soon, PhD, MD, PhD, MD, PhD, MD, PhD, MD, Pleyer, Uwe, Poór, Gyula, Proença, Rui, Rabinovitch, Theodore, Ramanan, Athimalaipet V., Read, Russell, Rebrov, Margarita, Recillas-Gispert, Claudia, Rosenbaum, James T., Rothova, Aniki, Salah, Sawsen, Salek, Sherveen, Schwartzman, Sergio, Seve, Pascal, Sharma, Srilakshmi, Siak, Jay, Sims, Joanne, Sohár, Nicolette, Sonoda, Koh-Hei, Steeples, Laura, Suhler, Eric, Szepessy, Zsuzsanna, Szántó, Sándor, Tappeiner, Christoph, the author FMedSci, Email, Thorne, Jennifer, Tugal Tutkun, Ilknur, Turno-Kręcicka, Anna, Van Calster, Joachim, van der Horst-Bruinsma, Irene, Vidovič Valentinčič, Nataša, Vitale, Albert, Voorduin Ramos, Stephanie, Vukojevic, Nenad, Wakefield, Denis, Willermain, François, Yalcindag, Nilufer, Yeh, Stephen, Zemaitiene, Reda, Ziouzina, Olga   +150 more
core   +1 more source

New approaches and therapeutic modalities for the treatment of patients with chronic hepatitis C

Annals of Hepatology, 2005
A major challenge in the field of hepatology is the fight against hepatitis C that affects more than 150 million people world-wide. Despite the enormous improvement that has been achieved in the therapy of chronic hepatitis C over the last decade, there ...
Markus Cornberg, Michael P. Manns
doaj   +1 more source

Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors [PDF]

, 2010
Histone deacetylase inhibitors (HDI) dampen cellular innate immune response by decreasing interferon production and have been shown to increase the growth of vesicular stomatitis virus and HSV.
Atkins, H, Bell, JC, Breitbach, C, Cox, J, De Silva, N, Diallo, JS, Falls, T, Guimond, T, Huang, B, Kirn, D, Le Boeuf, F, MacTavish, H, McCart, AJ, Simmons, JG, Stanford, M, Thorne, S   +15 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Cutaneous Sarcoidosis: An Uncommon Side Effect of Pegylated Interferon and Ribavirin Use for Chronic Hepatitis C

Case Reports in Gastroenterology, 2009
The treatment of chronic hepatitis C (CHC) has evolved in the past 15 years and combination of pegylated interferon plus ribavirin is its current standard therapy.
Elson Vidal Martins Jr., Ana Karla Gaburri, Debora Gaburri, Angelo Sementilli   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Efficacy and safety of interferon alfa-2b in the complex therapy of patients with chronic bacterial prostatitis: a multicenter randomized clinical trial

Лечащий Врач, 2023
Chronic bacterial prostatitis reduces the reproductive function of men and worsens the quality of life. Impairment of the immune system in chronic bacterial prostatitis requires immunocorrection and use of additional immunomodulatory therapy.
Kh. S. Ibishev, M. I. Kogan, V. V. Dubensky, Vl. V. Dubensky, I. S. Shormanov, A. S. Soloviev, I. V. Bazhenov, D. V. Romanenko, E. N. Vyzhlova   +8 more
doaj   +1 more source

An expert consensus for the management of chronic hepatitis B in Asian Americans. [PDF]

, 2018
BACKGROUND: Hepatitis B virus (HBV) infection is common with major clinical consequences. In Asian Americans, the HBsAg carrier rate ranges from 2% to 16% which approximates the rates from their countries of origin.
Abbas, Abbas, Ahn, Beasley, Beasley, Bisceglie, Bogr, Brown, Buti, Centers for Disease Control, Chae, Chan, Chang, Chang, Chang, Chang, Chang, Chao, Chaung, Chen, Chen, Chen, Chen, Chi, Chien, Choe, Chu, Clemente, Della Corte, European Association for the Study of the Liver, Evans, Fang, Fattovich, Fontana, Fung, Gish, Hadziyannis, Halperin, Hann, Heathcote, Hongthanakorn, Hoofnagle, Hu, Huang, Hung, Hyun, Iino, Iloeje, Jeng, Keeffe, Kim, Komatsu, Konstantinou, Kowdley, Kuo, Kwong, Lai, Lai, Lai, Lai, Lampertico, Lau, Lau, Lee, Lee, Liang, Liaw, Liaw, Liaw, Liew, Lin, Lin, Lin, Liu, Liu, Liu, Lok, Lok, Lok, Loomba, MacLachlan, Manegold, Marcellin, Marcellin, Marcellin, Marcellin, Marcellin, Marcellin, Martin, Martin-Carbonero, Mast, McClune, McMahon, Mitchell, Monte, Murata, Mutimer, Nafa, Nguyen, Nguyen, Nikolopoulos, Pan, Pan, Pan, Pan, Pan, Pan, Pan, Pan, Pan, Pan, Papatheodoridis, Park, Park, Park, Patterson, Perrillo, Perrillo, Pollack, Prati, Qiu, Reijnders, Sarin, Seto, Seto, Sherman, Shim, Shiraki, Sinatra, Sinn, Soriano, Stevens, Takano, Takayama, Takkenberg, Terrault, Thibault, Thio, Tong, Tong, Tong, Tong, Tong, Tong, Tong, Tong, Tong, Tong, Tong, Tong, Tong, Tong, Tse, Wang, Wedemeyer, Wei, Wen, Wiseman, Wursthorn, Xie, Xu, Yi, Yi, Yu, Yu, Yuen, Yuen, Yuen, Yuen, Yuen, Zhang, Zhang, Zhang, Zou   +173 more
core   +2 more sources