Results 11 to 20 of about 37,428 (161)

ADMINISTRATION CRITERIA FOR INTERFERON-BASED DRUGS AND ITS INDUCERS IN ACUTE RESPIRATORY INFECTIONS IN CHILDREN

Медицинская иммунология, 2014
. Interferon profile was studied in 412 children and 41 adults with acute respiratory virus infections, as well as in forty-eight healthy children and ninety-nine adults.
E. G. Golovacheva, L. W. Ossidak, E. V. Obrastsova, O. I. Afanasyeva   +3 more
doaj   +1 more source

A proteomic atlas of senescence-associated secretomes for aging biomarker development. [PDF]

, 2020
The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, ranging from neurodegeneration to cancer.
Basisty, Nathan, Campisi, Judith, Ferrucci, Luigi, Holtz, Anja, Jeon, Ok Hee, Kale, Abhijit, Kuehnemann, Chisaka, Payne, Therese, Rao, Chirag, Schilling, Birgit, Shah, Samah, Sharma, Vagisha   +11 more
core   +1 more source

TPNA10168, an Nrf-2 activator, attenuates inflammatory responses independently of Nrf2 in microglial BV-2 cells: Involvement of the extracellular-signal-regulated kinase pathway

Journal of Pharmacological Sciences, 2022
Some chemical Nrf2 inducers possess antioxidant and anti-inflammatory properties. TPNA10168, which was identified from a chemical library as a potential activator of the Keap1-Nrf2-ARE pathway, exhibits a neuroprotective effect against oxidative stress ...
Yasuhiko Izumi, Ai Tatsumoto, Naoko Horiuchi, Monami Arifuku, Momoko Uegomori, Toshiaki Kume, Yutaka Koyama   +6 more
doaj   +1 more source

Interferon Status and Choice of Interferons Inducers in Frequently Ill Children

Детские инфекции (Москва), 2016
Literature data on the study of interferon status in children. Own results of the survey group of frequently ill children (FIC) have shown insufficient production of IFN alpha and gamma-IFN, humoral immunity. It was revealed that 66% of the group FIC has
M. S. Savenkovа, O. V. Karashtinа, M. B. Shabat, G. N. Kraseva, N. A. Abramova, T. E. Kraseva   +5 more
doaj   +1 more source

Differential induction of TLR3-dependent innate immune signaling by closely related parasite species. [PDF]

PLoS ONE, 2014
The closely related protozoan parasites Toxoplasma gondii and Neospora caninum display similar life cycles, subcellular ultrastructure, invasion mechanisms, metabolic pathways, and genome organization, but differ in their host range and disease ...
Daniel P Beiting, Lucia Peixoto, Natalia S Akopyants, Stephen M Beverley, E John Wherry, David A Christian, Christopher A Hunter, Igor E Brodsky, David S Roos   +8 more
doaj   +1 more source

Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection. [PDF]

, 1994
Leishmania major are intramacrophage parasites whose eradication requires the induction of T helper 1 (Th1) effector cells capable of activating macrophages to a microbicidal state.
Locksley, RM, Reiner, SL, Stowring, L, Wang, ZE, Zheng, S   +4 more
core   +1 more source

Sequential Interferon β-Cisplatin Treatment Enhances the Surface Exposure of Calreticulin in Cancer Cells via an Interferon Regulatory Factor 1-Dependent Manner

Biomolecules, 2020
Immunogenic cell death (ICD) refers to a unique form of cell death that activates an adaptive immune response against dead-cell-associated antigens. Accumulating evidence indicates that the efficacy of conventional anticancer agents relies on not only ...
Pei-Ming Yang, Yao-Yu Hsieh, Jia-Ling Du, Shih-Chieh Yen, Chien-Fu Hung   +4 more
doaj   +1 more source

Study of the Activity of Antiviral Drugs Against the Causative Agent of Chikungunya Fever in Cell Culture

Антибиотики и Химиотерапия, 2023
Сhikungunya  virus (CHIKV) is a member of the Flavivirus genus, Flaviviridae family. It belongs to the zoonotic arbovirus infections transmitted by mosquitoes of the genus Aedes.
S. Ya. Loginova, V. N. Schukina, S. V. Savenko, R. V. Sakharov, S. V. Borisevich   +4 more
doaj   +1 more source

The pestivirus N terminal protease N(pro) redistributes to mitochondria and peroxisomes suggesting new sites for regulation of IRF3 by N(pro.) [PDF]

, 2014
The N-terminal protease of pestiviruses, N(pro) is a unique viral protein, both because it is a distinct autoprotease that cleaves itself from the following polyprotein chain, and also because it binds and inactivates IRF3, a central regulator of ...
C Achmüller, C Castanier, CA Benedict, D Hoepfner, E Dixit, E Peterhans, F Hou, HW Platta, Irina Mohorianu, JC Martinou, JE Vince, Karen L. Mossman, KE Taylor, KV Mohan, Matthew Jefferson, Matthew Whelband, MJ Killip, MR Szymanski, N Ruggli, N Zemirli, O Bauhofer, PB Lazarow, Penny P. Powell, R Higgs, RB Seth, RE Lloyd, S Chattopadhyay, S Paz, S Sharma, SA La Rocca, SM Belgnaoui, SW Tait, T Wolff, TJ Ettema, V Doceul, V Moennig, Y Li   +36 more
core   +2 more sources

ADJUVANT THERAPY FOR RECURRENT RESPIRATORY PAPILLOMATOSIS IN CHILDHOOD

Педиатрическая фармакология, 2006
The article outlines etiology, pathogenesis, clinical course, diagnostic, therapeutic and surgical treatment of recurrent respiratory papillomatosis (RRP) in childhood.
Yu.L. Soldatskiy
doaj   +2 more sources