Results 251 to 260 of about 50,714 (355)

Detection of fecal interferon-induced transmembrane protein messenger RNA for colorectal cancer screening

, 2010
Chie Miyamoto, Nobuki Miyamoto, Hiroyuki Yamamoto, Kohzoh Imai, Yasuhisa Shinomura   +4 more
openalex   +2 more sources

Interferon-α (IFN-α) suppresses HTLV-1 gene expression and cell cycling, while IFN-α combined with zidovudin induces p53 signaling and apoptosis in HTLV-1-infected cells [PDF]

, 2013
Shuichi Kinpara, Mami Kijiyama, Ayako Takamori, Atsuhiko Hasegawa, Amane Sasada, Takao Masuda, Yuetsu Tanaka, Atae Utsunomiya, Mari Kannagi   +8 more
openalex   +1 more source

Tubule‐Derived IFN‐α Promotes GSDMD‐Mediated Macrophage Pyroptosis to Drive Renal Inflammation and Fibrosis Through JAK2/STAT2 Activation

Advanced Science, EarlyView.
Mao and colleagues uncover a STAT2/IRF9‐dependent signaling axis through which tubular epithelial cell (TEC)‐derived IFN‐α induces gasdermin D (GSDMD)‐mediated pyroptosis in macrophages. This TEC‐macrophage feedback loop amplifies renal inflammation and fibrosis, providing mechanistic insight into the progression of chronic kidney disease and revealing
Yiping Xu, Yating Wang, Siming Jiang, Yi Li, Guanglan Li, Yuchu Liu, Siyuan Li, Yiming Zhou, Qinghua Liu, Yi Zhou, Wei Chen, Hongyu Li, Haiping Mao   +12 more
wiley   +1 more source

Ferroptosis of Immune Cells in Infection, Inflammation and Tumor Progression. [PDF]

Biomolecules
Xu H, Lu Y, Zeng Q, Zhu X, Guan W, Liu S.   +5 more
europepmc   +1 more source

Additional file 1: Table S1. of CXC chemokine superfamily induced by Interferon-Îł in asthma: a cross-sectional observational study

, 2016
Yotaro Takaku, Tomoyuki Soma, Yoshitaka Uchida, Takehito Kobayashi, Kazuyuki Nakagome, Makoto Nagata   +5 more
openalex   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Co-targeting ferroptosis and immune evasion through small molecules in breast cancer. [PDF]

J Transl Int Med
Zhou J, Yang W, Tang H, Zou Y, Zhou Z, Peng C, Peng F.   +6 more
europepmc   +1 more source

A Microbiota‐ and IL‐15‐Dependent Innate‐Like B Cell Progenitor Expressing E4BP4

Advanced Science, EarlyView.
This work identifies CD3.NKp46.CD19.NK1.1. NK‐B cells enriched in PDK1‐deficient yet present in wild‐type bone marrow. IL‐15 (via CD122) and TLR9‐microbiota signaling maintain their E4BP4 expression. These cells demonstrate innate immunity, preferentially differentiate into B cells, and unveil a novel microbiota‐ and IL‐15‐dependent regulatory pathway ...
Junming He, Xinlei Hou, Xiaomei Feng, Yayun Dong, Mengqi Ren, Surong Deng, Xinru Yang, Donglin Chen, Lingna Zhao, Shasha Chen, Meixiang Yang, Zhongjun Dong   +11 more
wiley   +1 more source

Harnessing ferroptosis for cancer therapy: Mechanisms and therapeutic strategies (Review). [PDF]

Oncol Rep
Mouawad N, El Jaafari N, El Sibai M, Abi-Habib RJ.   +3 more
europepmc   +1 more source

Bimetallic Peroxide Nanocomposites‐Driven Redox Dyshomeostasis to Activate Sequential Cuproptosis and Pyroptosis for Amplified Tumor Immunotherapy

Advanced Science, EarlyView.
Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He, Haixia Zhu, Peipei Kang, Lili Feng, Chenghao Yu, Yanlin Zhu, Bin Liu, Zhengxiao Guo, Piaoping Yang   +8 more
wiley   +1 more source