Summary The pre-treatment of mouse L cells with interferon or polyinosinic-polycytidylic acid potentiated the interferon response of these cells to subsequent stimulation with suboptimal doses of polyinosinic-polycytidylic acid. This potentiation was manifested as an earlier production of interferon, a faster attainment of maximum interferon production,
S A, Margolis, H, Oie, H B, Levy
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Regulation of Murine Class I Genes by Interferons is Controlled by Regions Located Both 5' and 3' to the Transcription Initiation Site [PDF]
Interferons regulate the expression of a large number of mammalian genes, including the major histocompatibility antigen genes. To investigate the mechanisms involved in interferon action, we have analyzed the ability of murine H-2Ld and H-2Dd DNA ...
Hood, Leroy +2 more
core +1 more source
Prospects for the use of interferon in the treatment of infertility in men
The characteristic of viruses of herpes simplex 1 and 2 types (HSV-1 and HSV-2) and the main clinical forms of infection in men was given. The pathogenesis of reproductive disorders in men with the participation of HSV is presented.
S. V. Rishchuk +6 more
doaj
IMMUNE THERAPY OF ENTEROVIRUS MENINGITIS IN CHILDREN
The authors analyzed 254 cases of Enteroviral Meningitis (EVM) in children that were treated in the children's department of neuroinfections ofClinicalHospital№40 inClinical andDiagnosticCenter. We compared the conventional method of the treatment of EVM
Yu. B. Hamanova +2 more
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Summary: The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is a major mediator of inflammation following stimulation with >45 bp double-stranded DNA (dsDNA).
Yao Liu +22 more
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FREQUENCY OF SIDE EFFECTS OF ANTIVIRUS THERAPY FOR CHRONIC VIRUS HEPATITIS IN CHILDHOOD
In pediatrics, the issue of using antivirus therapy for chronic virus hepatitis is not sufficiently studied, there is search for rational combinations, schemes, doses and length of treatment. The article demonstrates results of using a combined antivirus
S.V. Romanova +6 more
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A novel mechanism underlying the innate immune response induction upon viral-dependent replication of host cell mRNA: A mistake of +sRNA viruses' replicases [PDF]
Viruses are lifeless particles designed for setting virus-host interactome assuring a new generation of virions for dissemination. This interactome generates a pressure on host organisms evolving mechanisms to neutralize viral infection, which places the
Colombo, Maria Isabel +1 more
core +6 more sources
STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection. [PDF]
UnlabelledSTING (stimulator of interferon [IFN] genes) initiates type I IFN responses in mammalian cells through the detection of microbial nucleic acids. The membrane-bound obligate intracellular bacterium Chlamydia trachomatis induces a STING-dependent
Barker, Jeffrey R +6 more
core +2 more sources
Interferon-induced thrombotic microangiopathy [PDF]
Although drug-induced thrombotic microangiopathy (TMA) is commonly reported, evidence for a causal association is uncommonly documented. In this issue of Blood, Kavanagh et al use multiple methods to clearly establish a causal association of type I interferon with TMA ...
openaire +2 more sources
The Use of Interferon Inducers in an Infectious Disease Clinic
The article presents the scientific substantiation of the use of interferon inducers in an infectious disease clinic the inducers of endogenous interferon of various chemical groups with antiviral action are examined and analyzed.
A. A. Shuldyakov +6 more
doaj

