Results 61 to 70 of about 37,858 (296)

THEORETICAL AND APPLIED ASPECTS OF THE INTERFERON SYSTEM: TO THE 60TH ANNIVERSARY OF THE DISCOVERY OF INTERFERONS

Вопросы вирусологии, 2018
The review contains a brief analysis of the 60-year history of the discovery, study and medical application of interferons, a new group of remarkable proteins that have found wide medical application in the therapy of virological, oncological ...
F. I. Ershov, A. N. Narovlyansky
doaj   +1 more source

In vitro CRISPR screening uncovers CRTC3 as a regulator of IFN-γ-induced ferroptosis of hepatocellular carcinoma

Cell Death Discovery, 2023
Interferon-gamma (IFN-γ) exerts anti-tumor effects by inducing ferroptosis. Based on CRISPR/Cas9 knockout screening targeting genome-wide protein encoding genes in HepG2 and SK-Hep-1 cell lines, we found that cAMP response element-binding protein (CREB ...
Li Li, Tao Xing, Yiran Chen, Weiran Xu, Bo Fan, Gaoda Ju, Jing Zhao, Li Lin, Cihui Yan, Jun Liang, Xiubao Ren   +10 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Use of immunomodulators in infectious diseases of domestic animals/
Uso de imunomoduladores nas enfermidades infecciosas dos animais domésticos

Semina: Ciências Agrárias, 2007
Immunomodulators are substances that act in the immune system providing, increase of the organic answer against microorganisms, including virus, bacteria and protozoa, by inducing the production of interferon and its inducers.
Jane Megid, Camila Michele Appolinário
doaj   +1 more source

Вугрова хвороба:сучасні можливості лікування [PDF]

, 2010
Изучена эффективность использования макролидных антибиотиков и индукторов интерферона в комплексном лечении больных папуло-пустулезной формой угревой болезни. Установлено их позитивное влияние на клиническое течение заболевания, качество жизни пациентов,
Бєлай, І.М., Коваленко, Ю.Б., Носовська, Т.Д., Резніченко, Н.Ю., Резніченко, Ю.Г.   +4 more
core  

A pilot study of temsirolimus and body composition. [PDF]

, 2013
PurposeBody weight and composition play a role in cancer etiology, prognosis, and treatment response. Therefore, we analyzed the weight, body composition changes, and outcome in patients treated with temsirolimus, an mTor inhibitor that has weight loss ...
Janku, Filip, Kurzrock, Razelle, Naing, Aung, Parsons, Henrique A, Tsimberidou, Apostolia M, Veasey-Rodrigues, Heloisa, Wheler, Jennifer J   +6 more
core   +2 more sources

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Characterization, cloning and immunogenicity of antigens released by lung-stage larvae of Schistosoma mansoni [PDF]

, 1999
Lung-stage schistosomula are the target of protective immunity in mice vaccinated with attenuated cercariae of Schistosoma mansoni. Therefore, proteins present at this developmental stage, and in particular those which are secreted, are a potential ...
Coulson, P S, Harrop, R, Wilson, R A
core   +1 more source