Gene Expression Pattern of Peyer’s Patch Lymphocytes Exposed to Kagocel Suggests Pattern-Recognition Receptors Mediate Its Action [PDF]
Frontiers in Pharmacology, 2021 Kagocel is a synthetic carboxymethylcellulose derivative copolymerized with gossypol. Clinical data evidence its safety and efficiency for the treatment of flu and other viral infections via enhancement of interferon production.
Alexander A. Andreev-Andrievskiy +11 more
doaj +5 more sources
Antiviral therapy for influenza in high-risk outpatients: a multicenter observational study of routine clinical practice in Russia [PDF]
Therapeutic Advances in Infectious DiseaseBackground: Influenza is a significant public health challenge, characterized by severe disease progression and considerable societal burden. Patients at high risk of influenza-related complications require special attention in routine clinical practice.
Valery Tsvetkov +2 more
exaly +3 more sources
Role of Kagocel® in the treatment of recurrent herpes virus infections
Kliničeskij Razbor V Obŝej MedicineThe article provides a brief overview of the conceptual approach to the treatment of genital herpesvirus infections, a review of studies on the use of the interferon inducers Kagocel® in complex therapy of genital herpes, demonstrates clinical ...
Yuliya E. Dobrokhotova +2 more
exaly +4 more sources
Safety of the Russian antiviral drug Kagocel [PDF]
Терапевтический архив, 2017 The review gives summarized information on the preclinical data and clinical trials evaluating the safety of the antiviral drug Kagocel. It notes that the manufacturer of the drug pay special attention to the control of its impurity content.
T G Borovskaya
doaj +3 more sources
Antiviral Activity of Kagocel® on the Model of Experimental Lethal Influenza Infection
Антибиотики и Химиотерапия, 2020 Despite the obvious advances in vaccination and therapy, influenza remains a poorly controlled infection with high morbidity and mortality. This study examined the antiviral activity of interferon inducer Kagocel on a mouse model of lethal influenza ...
V. V. Zarubaev +4 more
doaj +3 more sources
Биопрепараты: Профилактика, диагностика, лечение, 2021 Kagocel® is used in Russia for the treatment of viral infections. In terms of its chemical structure, Kagocel® active ingredient is a copolymer of gossypol polyphenol and carboxymethylcellulose.
T. M. Sokolova, V. V. Poloskov
doaj +3 more sources
Kagocel in the therapy of influenza and acute respiratory viral infections: Data analysis and systematization from the results of preclinical and clinical trials [PDF]
Терапевтический архив, 2017 The article provides the summarized data of clinical trials evaluating the efficacy and safety of kagocel used to prevent and treat influenza and acute respiratory viral infections of different etiologies. The results of numerous preclinical and clinical
T V Sologub, V V Tsvetkov
doaj +3 more sources
Antiviral Activity of Kagocel® in vitro Against Virus SARS-CoV-2
Антибиотики и Химиотерапия, 2020 The antiviral activity of the drug Kagocel®, which has a high safety profile and proven efficacy for the prevention and treatment of influenza and AVRI as an interferon inducer, was studied against a new pandemic strain of SARS-CoV-2 in vitro in Vero ...
S. Ya. Loginova +3 more
doaj +4 more sources
Time course of changes in cytokines (IFN-γ, IFN-α, IL-18, TNF-α) in the treatment of moderate influenza A (H1N1) pdm09 (2013-2016) with oseltamivir (Tamiflu) and umifenovir (Arbidol) alone and in combination with Kagocel [PDF]
Терапевтический архив, 2017 Aim. To assess correlation of cytokines levels and therapy regimes a relationship of the time course of changes in the cytokines IFN-γ, IFN-α, IL-18, and TNF-α to the treatment option for influenza A (H1N1) pdm09 with umifenovir (Arbidol) 800 mg/day for ...
A F Popov +3 more
doaj +3 more sources
Инфекция и иммунитет, 2022 An effect of the antiviral drug Kagocel on the levels of metalloproteinases MMP-8 and MMP-9 and their tissue inhibitors TIMP-1 and TIMP-2 in induced sputum during treatment of community-acquired viral-bacterial pneumonia was analyzed.
Alexander F. Popov +4 more
doaj +1 more source