Results 61 to 70 of about 1,888,881 (401)

Activation and evasion of type I interferon responses by SARS-CoV-2

Nature Communications, 2020
The pandemic of COVID-19 has posed an unprecedented threat to global public health. However, the interplay between the viral pathogen of COVID-19, SARS-CoV-2, and host innate immunity is poorly understood.
X. Lei, Xiaojing Dong, Ruiyi Ma, Wenjing Wang, Xia Xiao, Zhongqin Tian, Conghui Wang, Ying Wang, Li Li, L. Ren, Fei Guo, Zhendong Zhao, Zhuo Zhou, Zichun Xiang, Jianwei Wang   +14 more
semanticscholar   +1 more source

The interferon-stimulated gene IFITM3 restricts infection and pathogenesis of arthritogenic and encephalitic alphaviruses [PDF]

, 2016
Host cells respond to viral infections by producing type I interferon (IFN), which induces the expression of hundreds of interferon-stimulated genes (ISGs).
Diamond, Michael S, Farzan, Michael, Gorman, Matthew J, Hyde, Jennifer L, Poddar, Subhajit   +4 more
core   +2 more sources

Dimerization of the Interferon Type I Receptor IFNaR2–2 Is Sufficient for Induction of Interferon Effector Genes but Not for Full Antiviral Activity*

Journal of Biological Chemistry, 1999
We constructed chimeric receptors wherein the extracellular domain of the erythropoietin receptor (EpoR) was fused to the transmembrane and intracellular domains of the interferon (IFN) type I receptor subunits, IFNaR1 or IFNaR2–2.
Els Pattyn, X. Van Ostade, L. Schauvliege, A. Verhee, M. Kalai, J. Vandekerckhove, J. Tavernier   +6 more
semanticscholar   +1 more source

Type I and III interferon responses in SARS-CoV-2 infection

Experimental and Molecular Medicine, 2021
Coronavirus disease 2019 (COVID-19), the current pandemic disease, is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
You-Me Kim, E. Shin
semanticscholar   +1 more source

Fine-Tuning of Type I Interferon Response by STAT3

Frontiers in Immunology, 2019
Type I interferon (IFN-I) is induced during innate immune response and is required for initiating antiviral activity, growth inhibition, and immunomodulation. STAT1, STAT2, and STAT3 are activated in response to IFN-I stimulation.
Ming-Hsun Tsai, Li-Mei Pai, Li-Mei Pai, Li-Mei Pai, Chien-Kuo Lee   +4 more
doaj   +1 more source

Investigation of type I interferon responses in ANCA-associated vasculitis

Scientific Reports, 2021
Type I interferon (IFN) dysregulation is a major contributory factor in the development of several autoimmune diseases, termed type I interferonopathies, and is thought to be the pathogenic link with chronic inflammation in these conditions.
Isabella Batten, Mark W. Robinson, Arthur White, Cathal Walsh, Barbara Fazekas, Jason Wyse, Antonia Buettner, Suzanne D’Arcy, Emily Greenan, Conor C. Murphy, Zoe Wigston, Joan Ní Gabhann-Dromgoole, Edward M. Vital, Mark A. Little, Nollaig M. Bourke   +14 more
doaj   +1 more source

Reactive oxygen species induce virus-independent MAVS-oligomerization in systemic lupus erythematosus [PDF]

, 2016
The increased expression of genes induced by type I interferon (IFN) is characteristic of viral infections and systemic lupus erythematosus (SLE). We showed that mitochondrial antiviral signaling (MAVS) protein, which normally forms a complex with ...
Budd, Ralph C., Buskiewicz, Iwona A., Crow, Mary K., Hartley, Richard C., Huber, Sally A., Kelly, Ryan, Koenig, Andreas, Montgomery, Theresa, Murphy, Michael P., Perl, Andras, Yasewicz, Elizabeth C.   +10 more
core   +1 more source

Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19

Science Translational Medicine, 2021
Description Type I interferon autoantibodies in patients with COVID-19 are associated with poor interferon responses and increased LAIR1 abundance in leukocytes.
M. V. D. van der Wijst, S. Vazquez, G. Hartoularos, Paul Bastard, T. Grant, R. Bueno, David S. Lee, J. Greenland, Yang Sun, Richard K. Perez, A. Ogorodnikov, A. Ward, S. Mann, K. Lynch, C. Yun, D. Havlir, G. Chamie, C. Marquez, B. Greenhouse, M. Lionakis, P. Norris, L. Dumont, K. Kelly, Peng Zhang, Qian Zhang, A. Gervais, Tom Le Voyer, Alexander Whatley, Yichen Si, A. Byrne, A. Combes, A. Rao, Yun S. Song, G. Fragiadakis, K. Kangelaris, C. Calfee, D. Erle, C. Hendrickson, M. Krummel, P. Woodruff, C. Langelier, J. Casanova, J. Derisi, Mark S. Anderson, Chun Jimmie Ye   +44 more
semanticscholar   +1 more source

Type I Interferons in Host Defense [PDF]

Immunity, 2006
Type I interferons (IFNs) are a family of cytokines specialized to coordinate immunity to viruses and other intracellular infections. In the past several years, many of the receptors and signaling pathways that link pathogen detection to induction of type I IFNs have been identified and characterized.
Stetson, Daniel B., Medzhitov, Ruslan
openaire   +2 more sources

Improved Innate and Adaptive Immunostimulation by Genetically Modified HIV-1 Protein Expressing NYVAC Vectors. [PDF]

, 2011
Attenuated poxviruses are safe and capable of expressing foreign antigens. Poxviruses are applied in veterinary vaccination and explored as candidate vaccines for humans.
A Alcami, A Alcami, A Harari, A Harari, A Subramanian, Abdelali Filali-Mouhim, AD Bins, AJ McNeil, Alexandre Harari, Anke Redeker, Antonio Lanzavecchia, B Perdiguero, Beatriz Perdiguero, Bertram L. Jacobs, Carmen E. Gomez, CE Gomez, CE Gomez, CE Gomez, CF Ockenhouse, CJM Melief, Clive Gray, Cornelis J. M. Melief, D Chaussabel, D Gaucher, David M. Koelle, DD Richman, DH O'Connor, DR Burton, E Paoletti, E Tryniszewska, Elias K. Haddad, Esther D. Quakkelaar, Federica Sallusto, Ferry Ossendorp, G Sutter, Giuseppe Pantaleo, GK Smith, J Tartaglia, J Tartaglia, JA Espmark, JA Symons, Jean-Philippe Goulet, Jim Tartaglia, JL Najera, JL Najera, Karen V. Kibler, L Jing, L Jing, LJ Sigal, M Carrington, M Esteban, M Terajima, Mariano Esteban, ME Perkus, ME Perkus, MJ Kuroda, MP Longhi, N Frahm, N Frahm, N Oguiura, N Romani, N van Montfoort, NA Wilson, Nikki M. Loof, OR Colamonici, P Mooij, P Mooij, PA Bart, Paul Heinen, RA Koup, Rafick P. Sékaly, RN Van Gelder, RP Sekaly, S Guerra, S McCormack, S Rerks-Ngarm, SA Migueles, SS Jackson, Stella Mayo McCaughey, Thomas Duhen, X Shen, X Wei, Y Benjamini, Z Hel, Z Hel   +84 more
core   +4 more sources