Results 71 to 80 of about 27,000,079 (254)

The transient nature of bunyamwera orthobunyavirus NSs protein expression : effects of increased stability of NSs protein on virus replication [PDF]

, 2013
The NSs proteins of bunyaviruses are the viral interferon antagonists, counteracting the host's antiviral response to infection. During high-multiplicity infection of cultured mammalian cells with Bunyamwera orthobunyavirus (BUNV), NSs is rapidly ...
Fragkoudis, R., Rennos Fragkoudis, Richard M Elliott, Ingeborg van Knippenberg, van Knippenberg, I., van Knippenberg, Ingeborg, Fragkoudis, Rennos, Elliott, Richard M., Elliott, R.M.   +8 more
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

The role of PML proteins in adenovirus type 5 infection and the type I interferon response [PDF]

Promyelocytic leukaemia (PML) proteins consist of a collection of related isoforms that are the nucleating components of sub-nuclear structures termed PML nuclear bodies (PML NBs). Numerous functions are attributed to PML and PML NBs, including a role
Wright, Jordan
core  

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo [PDF]

, 2008
The early systemic production of interferon (IFN)-alphabeta is an essential component of the antiviral host defense mechanisms, but is also thought to contribute to the toxic side effects accompanying gene therapy with adenoviral vectors.
György Fejer, Hildenbrand, B., Schleicher, U, Hildenbrand, Bernd, Marina A Freudenberg, Fejer, G., Greber, U., Ruzsics, Zsolt, Drechsel, Lisa, Fejer György, Imelli, N., Imelli, N, Ruzsics, Z., Krug Anne, Christian Bogdan, Keck, S., Zsolt Ruzsics, Lisa Drechsel, Hildenbrand Bernd, Drechsel, L., Simone Keck, Schleicher, Ulrike, Bogdan, C, Liese, J., Freudenberg, M., Bogdan, C., Schleicher Ulrike, Bogdan Christian, Ulrike Schleicher, Keck Simone, Krug, A., Fejer, György, Schleicher, U., Bogdan, Christian, Greber Urs F., Freudenberg, M A, Nicola Imelli, Krug, A, Greber, Urs F., Drechsel Lisa, Keck, S, Liese Jan, Krug, Anne, Jan Liese, Drechsel, L, Ruzsics, Z, Ruzsics Zsolt, Hildenbrand, B, Imelli, Nicola, Freudenberg, Marina A., Freudenberg Marina A., Bernd Hildenbrand, Urs F Greber, Fejer, G, Liese, J, Keck, Simone, Anne Krug, Greber, U F, Imelli Nicola, Liese, Jan   +59 more
core   +2 more sources

Complexities of Type I Interferon Biology: Lessons from LCMV

Viruses, 2019
Over the past decades, infection of mice with lymphocytic choriomeningitis virus (LCMV) has provided an invaluable insight into our understanding of immune responses to viruses.
Tamara Suprunenko, Markus J. Hofer
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Mumps virus Enders strain is sensitive to interferon (IFN) despite encoding a functional IFN antagonist [PDF]

, 2009
Although the Enders strain of mumps virus (MuV) encodes a functional V protein that acts as an interferon (IFN) antagonist, in multi-cycle growth assays MuV Enders grew poorly in naive ('IFN-competent' Hep2) cells but grew to high titres in 'IFN ...
Rima, B K, Andrejeva, Jelena, K. Lemon, B. K. Rima, Duprex, P, W. P. Duprex, M. C. Galiano, Galiano, M, J. Andrejeva, D. F. Young, R. E. Randall, Young, D F, Lemon, K, Chen, Y-H, Y.-H. Chen, Randall, Richard Edward   +15 more
core   +1 more source

Understanding Further the Phenotypic Spectrum of Central Nervous System Inflammatory Demyelinating Disorders Using Unsupervised Clustering

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Central nervous system (CNS) inflammatory demyelinating syndromes, including multiple sclerosis (MS), aquaporin‐4 antibody–positive neuromyelitis optica spectrum disorder (AQP4 + NMOSD), and myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD), occasionally overlap.
Bade Gulec, Elif Everest, Melih Tutuncu, Ugur Bilge, Sabahattin Saip, Ugur Uygunoglu, Aksel Siva   +6 more
wiley   +1 more source

Differential host responses by the type I and III interferons in primary differentiated human nasal epithelial cells are a determinant of antiviral activity

Frontiers in Pharmacology
BackgroundThe interferon (IFN) response is a crucial innate antiviral defence mechanism at the airway epithelium. The epithelial IFN response is predominantly mediated by the type I (IFN-β1) and III (IFN-λ) IFNs, which activate a transcriptional program ...
Douglas Jie Wen Tay, Douglas Jie Wen Tay, Hui Yi Tay, Hui Yi Tay, Justin Jang Hann Chu, Justin Jang Hann Chu, Justin Jang Hann Chu, Kai Sen Tan, Kai Sen Tan   +8 more
doaj   +1 more source