Results 91 to 100 of about 316,567 (264)

Evaluation of the interaction between tumor growth factor-β and interferon type I pathways in patients with COVID-19: focusing on ages 1 to 90 years. [PDF]

BMC Infect Dis, 2023
Abbasifard M, Fakhrabadi AH, Bahremand F, Khorramdelazad H.   +3 more
europepmc   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source

TRIM28 facilitates type I interferon activation by targeting TBK1

Frontiers in Immunology
Type I interferons play a fundamental role in innate host defense against viral infections by eliciting the induction of an antiviral gene program that serves to inhibit viral replication.
Fang Hua, Tim Nass, Kislay Parvatiyar
doaj   +1 more source

Astrocyte Control of Zika Infection Is Independent of Interferon Type I and Type III Expression. [PDF]

Biology (Basel), 2022
Das M, Smith ML, Furihata T, Sarker S, O'Shea R, Helbig KJ.   +5 more
europepmc   +1 more source

Context-dependent impact of type I interferon signaling in cancer

Molecular Cancer
Type I interferon (IFN) has long been known as a critical component of the molecular machinery that first responds to viral infection in multicellular eukaryotes.
Ainhoa Ruiz-Iglesias, Emma Guilbaud, Lorenzo Galluzzi, Santos Mañes   +3 more
doaj   +1 more source

Clinical efficacy and safety of interferon (Type I and Type III) therapy in patients with COVID-19: A systematic review and meta-analysis of randomized controlled trials. [PDF]

PLoS One, 2023
Ryoo S, Koh DH, Yu SY, Choi M, Huh K, Yeom JS, Heo JY.   +6 more
europepmc   +1 more source

Temporal Immune and Metabolic Shifts Drive the Anti‐Tumor Efficacy of Resiquimod‐Loaded Nanoparticles in Peritoneal Carcinomatosis

Advanced Healthcare Materials, EarlyView.
Peritoneal carcinomatosis is a hard‐to‐treat spread of abdominal cancers that often returns after therapy. Nanoparticles were developed to retain an immune‐boosting drug in the abdomen. When combined with chemotherapy in mice, this approach eliminated tumors in many cases and prevented recurrence, helping the immune system mount a stronger, longer ...
Vanessa Chan, Po‐Han Chao, XuXin Sun, Jun Han, Sarah MacPherson, Lucas J. Andrew, Noah Y. Brittain, Tien Do, Marcel B. Bally, Julian J. Lum, Shyh‐Dar Li   +10 more
wiley   +1 more source

MicroRNA-200c-targeted contactin 1 facilitates the replication of influenza A virus by accelerating the degradation of MAVS

PLoS Pathogens, 2022
Influenza A viruses (IAVs) continuously challenge the poultry industry and human health. Elucidation of the host factors that modulate the IAV lifecycle is vital for developing antiviral drugs and vaccines. In this study, we infected A549 cells with IAVs
Shuai Xu, Lu Han, Yanli Wei, Bo Zhang, Qian Wang, Junwen Liu, Minxuan Liu, Zhaoshan Chen, Zhengxiang Wang, Hualan Chen, Qiyun Zhu   +10 more
doaj  

COVID-19 pandemic-associated chilblains: more links for SARS-CoV-2 and less evidence for high interferon type I systemic response. [PDF]

Br J Dermatol, 2022
Bessis D, Trouillet-Assant S, Secco LP, Bardin N, Blanc B, Blatière V, Chable-Bessia C, Delfour C, Girard C, Richard JC, Gros N, Le Moing V, Molinari N, Pallure V, Pisoni A, Raison-Peyron N, Reynaud E, Schwob É, Pescarmona R, Samaran Q, Willems M, Vincent T, Sofonea MT, Belot A, Tuaillon É.   +24 more
europepmc   +1 more source