Results 71 to 80 of about 1,888,881 (401)

Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected [PDF]

, 2017
The recent global outbreak of Zika virus (ZIKV) infection has been linked to severe neurological disorders affecting the peripheral and central nervous systems (PNS and CNS, respectively). The pathobiology underlying these diverse clinical phenotypes are
Barnett, Susan C., Barrie, Jennifer A., Brennan, Benjamin, Cumberworth, Stephanie L., Cunningham, Madeleine E., de Oliveira França, Rafael Freitas, Edgar, Julia M., Gomes de Figueiredo, Daniely Paulino, Kohl, Alain, Linington, Christopher, Pena, Lindomar J., Schultz, Verena, Wilder-Smith, Adrian J., Willison, Hugh J.   +13 more
core   +1 more source

The interferon type I signature towards prediction of non-response to rituximab in rheumatoid arthritis patients

Arthritis Research & Therapy, 2012
IntroductionB cell depletion therapy is efficacious in rheumatoid arthritis (RA) patients failing on tumor necrosis factor (TNF) blocking agents. However, approximately 40% to 50% of rituximab (RTX) treated RA patients have a poor response.
H. Raterman, S. Vosslamber, S. de Ridder, M. Nurmohamed, W. Lems, M. Boers, M. A. van de Wiel, B. Dijkmans, C. Verweij, A. Voskuyl   +9 more
semanticscholar   +1 more source

Human plasmacytoid dendritic cells and cutaneous melanoma [PDF]

, 2020
The prognosis of metastatic melanoma (MM) patients has remained poor for a long time. However, the recent introduction of effective target therapies (BRAF and MEK inhibitors for BRAFV600-mutated MM) and immunotherapies (anti-CTLA-4 and anti-PD-1) has ...
Bugatti, Mattia, Consoli, Francesca, Monti, Matilde, Vermi, William, Vescovi, Raffaella   +4 more
core   +2 more sources

Opposing roles for interferon regulatory factor-3 (IRF-3) and type I interferon signaling during plague. [PDF]

PLoS Pathogens, 2012
Type I interferons (IFN-I) broadly control innate immunity and are typically transcriptionally induced by Interferon Regulatory Factors (IRFs) following stimulation of pattern recognition receptors within the cytosol of host cells.
Ami A Patel, Hanni Lee-Lewis, Jennifer Hughes-Hanks, Craig A Lewis, Deborah M Anderson   +4 more
doaj   +1 more source

Type I interferons in infectious disease [PDF]

Nature Reviews Immunology, 2015
Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the induction of other mediators. Type I IFNs are important for host defence against viruses.
Finlay McNab, Katrin Mayer-Barber, Alan Sher, Andreas Wack, Anne O'Garra   +4 more
openaire   +2 more sources

Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection [PDF]

, 2017
The requirement of type I interferon (IFN) for natural killer (NK) cell activation in response to viral infection is known, but the underlying mechanism remains unclear. Here, we demonstrate that type I IFN signaling in inflammatory monocytes, but not in
Ashkar, Ali A, Barra, Nicole G, Chen, Branson, Chew, Marianne V, Jordana, Manel, Lee, Amanda J, Mack, Matthias, Mossman, Karen L, Nham, Tina, Rooijen, Nico van, Schreiber, Robert D, Shenouda, Mira M   +11 more
core   +2 more sources

The anti-interferon activity of conserved viral dUTPase ORF54 is essential for an effective MHV-68 infection. [PDF]

PLoS Pathogens, 2011
Gammaherpesviruses such as KSHV and EBV establish lifelong persistent infections through latency in lymphocytes. These viruses have evolved several strategies to counteract the various components of the innate and adaptive immune systems. We conducted an
Ronika Sitapara Leang, Ting-Ting Wu, Seungmin Hwang, Lidia T Liang, Leming Tong, Jennifer T Truong, Ren Sun   +6 more
doaj   +1 more source

Dengue and Zika virus cross-reactive human monoclonal antibodies protect against Spondweni virus infection and pathogenesis in mice [PDF]

, 2019
Summary: Spondweni virus (SPOV) is the flavivirus that is most closely related to Zika virus (ZIKV). Although SPOV causes sporadic human infections in Africa, recently it was found in Culex mosquitoes in Haiti.
Aliota, Ansarah-Sobrinho, Barba-Spaeth, Cerbino-Neto, Cugola, Culshaw, Dejnirattisai, Dejnirattisai, Dowd, Draper, Driggers, Elong Ngono, Falk, Fernandez, Fox, Goncé, Gorman, Govero, Grant, Haddow, Haddow, Halstead, Hasan, Hessell, Jagger, Kokernot, Lanciotti, Lazear, Ma, MacNamara, Mansuy, Mansuy, Mansuy, McDonald, Miner, Morrison, Morrison, Mukherjee, Nguyen, Oliphant, Pal, Pierson, Pierson, Platt, Richner, Rossi, Rouvinski, Sapparapu, Sheehan, Suy, Taraphdar, White, Zhao   +52 more
core   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Analysis of tick-borne encephalitis virus-induced host responses in human cells of neuronal origin and interferon-mediated protection [PDF]

, 2017
Tick-borne encephalitis virus (TBEV) is a member of the genus Flavivirus. It can cause serious infections in humans that may result in encephalitis/meningoencephalitis. Although several studies have described the involvement of specific genes in the host
Grubhoffer, Libor, Gu, Quan, Kohl, Alain, Schnettler, Esther, Selinger, Martin, Tong, Lily, Wilkie, Gavin S.   +6 more
core   +2 more sources