Results 111 to 120 of about 419,491 (364)
Interferons: Reprogramming the Metabolic Network against Viral Infection
Viruses, 2018 Viruses exploit the host and induce drastic metabolic changes to ensure an optimal environment for replication and the production of viral progenies.
K. Raniga, C. Liang
semanticscholar +1 more source
FEBS Open Bio, EarlyView.GPR142, a tryptophan‐sensing receptor, stimulates gastrointestinal hormones like ghrelin and is linked to inflammation regulation. Proinflammatory cytokines suppress ghrelin production, while tryptophan levels decrease via IDO1 activation. Our findings reveal that proinflammatory cytokines directly regulate GPR142 expression in ghrelin‐producing cells,
Yoko Ueda +15 more
wiley +1 more source
Gut and Liver, 2009 Background/Aims: Interferon beta (IFN-Ղ) has been shown to have antiviral activity, and thus could be useful in treating viral infections. Therefore, we compared the efficacy and safety of recombinant IFN-Ղ (IFN-Ղ-1a) plus oral ribavirin versus ...
doaj +1 more source
Pathogenic Effects of IFIT2 and Interferon-β during Fatal Systemic
mBio, 2018 A balanced immune response to infection is essential to prevent the pathology and tissue damage that can occur from an unregulated or hyperactive host defense.
Marcin Stawowczyk +5 more
doaj +1 more source
Viruses, 2020 Oropouche orthobunyavirus (OROV) is an emerging arbovirus with a high potential of dissemination in America. Little is known about the role of peripheral blood mononuclear cells (PBMC) response during OROV infection in humans.
Mariene Ribeiro Amorim +18 more
doaj +1 more source
Contribution of type III interferons to antiviral immunity: location, location, location
Journal of Biological Chemistry, 2017 Type I interferons (IFN-α/β) and the more recently identified type III IFNs (IFN-λ) function as the first line of defense against virus infection and regulate the development of both innate and adaptive immune responses.
S. Kotenko, J. Durbin
semanticscholar +1 more source
Neurosignals, 2019 While the role of interferon during systemic disease is well known and its immune modulating functions and its role in antiviral activity were extensively studied, the role of IFN-I in the brain is less clear. Here we summarize the most important literature on IFN in homeostasis of the CNS and induction of an IFN response during viral infection in the ...
Bhat, Hilal +3 more
openaire +4 more sources
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
Information Mining for COVID-19 Research From a Large Volume of Scientific Literature [PDF]
arXiv, 2020 The year 2020 has seen an unprecedented COVID-19 pandemic due to the outbreak of a novel strain of coronavirus in 180 countries. In a desperate effort to discover new drugs and vaccines for COVID-19, many scientists are working around the clock. Their valuable time and effort may benefit from computer-based mining of a large volume of health science ...
arxiv
FEBS Open Bio, EarlyView.We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang +9 more
wiley +1 more source