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Interim analysis in clinical trials
Statistics in Medicine, 1991AbstractThe early development of experimental design discouraged a sequential approach to the analysis of data, yet this seems a natural form of scientific enquiry. Clinical trial investigators should continuously monitor the quality of their techniques, but will often wish to delegate data monitoring to an independent group.
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Fluoridation II: An interim economic analysis
Australian Dental Journal, 1980Abstract— Reductions in treatment costs in the South Australian School Dental Service attributed to water fluoridation were compared with fluoridation costs. Before making comparisons, costs and savings were adjusted to constant denominators by processes of deflation and application of social discount rates.
S M, Carr, M B, Dooland, D M, Roder
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Abstract The different considerations for interim analysis in Phase I, II, and III studies are provided.
Phil Ambery +2 more
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Phil Ambery +2 more
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Bayesian interim analysis in clinical trials
Contemporary Clinical Trials, 2008We propose a Bayesian approach to monitor clinical trials with clustered binary outcomes using multivariate probit models. Our monitoring is based on the calculated probability of the reduced incidence rate using a new treatment compared with the standard treatment greater than a target improvement under different prior scenarios for the treatment ...
Xiao, Zhang, Gary, Cutter
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Interim Analysis of STR Effectiveness
1978The present report describes the status of the NHTSA Short Term Rehabilitation Study (STR) as of December, 1977, and summarizes the progress of data collection efforts by the eleven participating ASAP projects. Outcome measures considered as indicative of treatment program effects include: (1) indices of accident and arrest recidivism reflective of the
Struckman-Johnson, D. L. (David L.) +3 more
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Adaptive Trials and Interim Analysis
2018This chapter discusses the important aspect of changing trial aspects, including analyzing data, before formal completion of a trial. Interim analysis (or analyses before trial is finished) should be planned and described in the study protocol, before starting the trial, to ensure the potential penalties for doing such analyses do not invalidate trial ...
Priscila Caldeira Andrade +4 more
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Policies for interim analysis and interim reporting of results.
Cancer treatment reports, 1985The key ethical issues involved in developing policies for interim reports and interim analyses are considered. Then the twin topics of the appropriate contents of interim reports and the components of an appropriate interim analysis are discussed. Finally, suggested policies are offered.
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[Comparison of Bayesian interim analysis and classical interim analysis in group sequential design].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2016To explore the differences between the Bayesian interim analysis and the classical interim analysis.To compare the means of two independent samples between control and treatment, superior hypothesis test was established. In line with the data requirements for group sequential design, Type Iota error of Bayesian interim analysis based on various prior ...
Lingling, Yuan +2 more
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Interim Cavalry Regiment Analysis
2001Abstract : The reorganization of the 2nd Armored Cavalry Regiment (ACR) was examined using the Janus model. The primary questions being examined were the different organizational structures and the sizing of the Mobile Gun System (MOS) Platoon. This analysis utilized two scenarios; a zone reconnaissance and a moving flank guard on Eastern European ...
Lawrence G. Vowels, Karl Gingrich
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