Results 51 to 60 of about 16,640,145 (271)
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Computing Weighted Analytic Center for Linear Matrix Inequalities Using Infeasible Newton’s Method
Journal of Mathematics, 2015 We study the problem of computing weighted analytic center for system of linear matrix inequality constraints. The problem can be solved using Standard Newton’s method.
Shafiu Jibrin
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
A Primal–Dual Interior Point Method for Complex–Variable Optimization Problems
International Journal of Applied Mathematics and Computer ScienceIn this paper, we propose a primal-dual interior-point method for solving convex optimization problems with complex variables, relying on a newly defined complex-valued kernel function.
Laouar Mounia +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
A decomposition-based warm-start method for stochastic programming [PDF]
, 2013 In this paper we propose a warm-start technique for interior point methods applicable to multi-stage stochastic linear programming problems. The main idea is to generate an initial point by decomposing the problem at the second stage and using an ...
Colombo, Marco +3 more
core +1 more source
Solving large scale linear programming [PDF]
, 1993 The interior point method (IPM) is now well established as a competitive technique for solving very large scale linear programming problems. The leading variant of the interior point method is the primal dual - predictor corrector algorithm due to ...
Levkovitz, R, Mitra, G, Hafsteinsson, H
core +4 more sources
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
A Piecewise Linear Programming Algorithm for Sparse Signal Reconstruction
Tsinghua Science and Technology, 2017 In order to recover a signal from its compressive measurements, the compressed sensing theory seeks the sparsest signal that agrees with the measurements, which is actually an l0 norm minimization problem.
Kuangyu Liu +3 more
doaj +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source