Results 221 to 230 of about 30,833,634 (232)

Magneto‐NIR‐II‐Programmed Cascade Nanozymes Unlocking Blood–Brain Barrier Translocation and Autophagic Resistance in Glioblastoma

Advanced Science, EarlyView.
Magneto‐NIR‐II‐programmed NFSH nanozymes integrate magnetic blood–brain barrier (BBB) translocation, CD44 targeting, multimodal imaging, and cascade catalytic therapy for glioblastoma. Alternating magnetic fields and NIR‐II irradiation amplify ferroptosis, release H2S, suppress autophagic and mitophagic repair, and reshape the immune microenvironment ...
Ruocan Liu, Yundi Wu, Shuai Zhang, Hongjuan Zhao, Jiping Zheng, Shiyang Shao, Jianqiang Chen, Xilong Wu   +7 more
wiley   +1 more source

Diagnostic utility of circulating interleukin-1 beta and microRNA-146a in differentiating febrile seizures from other pediatric conditions. [PDF]

World J Exp Med
Mohammadi S, Abbood Hameed Ati M, Seyedhosseini FS, Zare Ebrahimabad M, Saeidi M, Hosseini SA, Darweesh M, Al-Harrasi A, Yazdani Y.   +8 more
europepmc   +1 more source

A pH‐Switchable Cerium Single‐Atom Enzyme for Peri‐Implantitis Therapy via JAK‐STAT Signaling Axis‐Mediated Macrophage Reprogramming

Advanced Science, EarlyView.
A pH‐switchable cerium single‐atom enzyme is developed for stage‐specific peri‐implantitis therapy. Acidic conditions trigger antibacterial peroxidase‐like activity, whereas neutral conditions activate an antioxidant superoxide dismutase ‐ and catalase ‐like enzymatic relay. This microenvironment‐adaptive catalytic strategy suppresses the IL‐6/JAK‐STAT
Xiaomin Xia, Haojie Wu, Xingyun Li, Lining Liu, Kaiqing Song, Jinpei Cui, Jie Liu, Jiaxuan Yin, Emtiaz Ahmed, Yusuke Yamauchi, Xue Li   +10 more
wiley   +1 more source

Massive idiopathic pericardial effusion in a pediatric patient responsive to interleukin-1 receptor antagonist: Unveiling an undercover hyperinflammation? [PDF]

Ann Pediatr Cardiol
Pasquinucci M, Arcidiacono CM, Volpi S, Formigari R.   +3 more
europepmc   +1 more source

A C‐Nucleoside Analogue of Cordycepin With High Metabolic Stability and Potent Anti‐Psoriatic Activity via Microneedle Delivery

Advanced Science, EarlyView.
This work identified CPD3a as a potent, stable C‐nucleoside cordycepin derivative. When formulated into microneedle array for topical treatment, it ameliorated psoriasis by rebalancing immunity and enhancing antioxidant defenses. ABSTRACT Psoriasis is a chronic inflammatory disorder characterized by immune dysregulation and epidermal hyperplasia ...
Wenfang Pan, Xinyue Shao, Yuanchen Zhong, Xujie Sun, Lixuan Yin, Zongyan He, Tianqun Lang, Yuanchao Xie   +7 more
wiley   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Alcohol drinking sex-dependently regulates interleukin-1 pro-inflammatory signaling in the prefrontal cortex of mice and rhesus macaques. [PDF]

Brain Behav Immun
Liss A, Lowe CC, Siddiqi MT, Podder D, Scroger MV, Vessey G, Martin K, Paperny NM, Lam DM, Martin AE, Bacar JN, Vo KT, Astefanous A, Belachew N, Idahor E, Davenport AT, Daunais JB, Hayes WM, Cervera-Juanes R, Davis TD, Varodayan FP.   +20 more
europepmc   +1 more source

Tinea labialis in a patient with Schnitzler syndrome on interleukin-1 receptor antagonist. [PDF]

JAAD Case Rep
Mooney N, Grewal A, Pei S, Bogner P, Kuraitis D.   +4 more
europepmc   +1 more source

A Multi-Omics Approach Reveals Interleukin 1 Beta Priming as a Key Driver of Immunomodulatory and Regenerative Programs in Adipose-Derived Stem Cells for Osteoarthritis Therapy. [PDF]

Cells
Miceli V, Ligotti ME, Raffo V, Lopa S, Ippolito V, Gallo A, Cuscino N, Scilabra SD, Lo Pinto M, Messina S, D'Arpa S, Moretti M, de Girolamo L, Bulati M, Colombini A.   +14 more
europepmc   +1 more source

Interleukin-1 receptor-associated kinase-1 is a therapeutic target for gastric cancer. [PDF]

Discov Oncol
Shi H, Zhang J, Bao X.
europepmc   +1 more source