Methylation-Dependent Gene Silencing Induced by Interleukin 1β via Nitric Oxide Production [PDF]
The Journal of Experimental Medicine, 1999 Interleukin (IL)-1β is a pleiotropic cytokine implicated in a variety of activities, including damage of insulin-producing cells, brain injury, or neuromodulatory responses. Many of these effects are mediated by nitric oxide (NO) produced by the induction of NO synthase (iNOS) expression. We report here that IL-1β provokes a marked repression of genes,
Hmadcha, Abdelkrim +3 more
openaire +4 more sources
Polyene Macrolide Antifungal Drugs Trigger Interleukin-1β Secretion by Activating the NLRP3 Inflammasome [PDF]
PLoS ONE, 2011 The use of antimycotic drugs in fungal infections is based on the concept that they suppress fungal growth by a direct killing effect. However, amphotericin and nystatin have been reported to also trigger interleukin-1β (IL-1β) secretion in monocytes but the molecular mechanism is unknown.
Darisipudi, Murthy Narayana +3 more
openaire +5 more sources
BMC Molecular and Cell Biology, 2022 Background Acetaminophen is commonly recommended for the early analgesia of osteoarthritis. However, the molecular mechanism by which it acts remains unknown.
Jie Gao +4 more
doaj +1 more source
Truncated Chicken Interleukin-1β with Increased Biologic Activity [PDF]
, 2003 Chicken interleukin-1β (ChIL-1β) is synthesized as a precursor molecule that unlike its mammalian counterpart, lacks a typical caspase-1 cleavage site. Therefore, it was unclear if proteolytic cleavage of ChIL-1β can occur and if cleavage might modulate ...
Duda, Erno +4 more
core +1 more source
Peptidoglycan and teichoic acid fromStaphylococcus epidermidisstimulate human monocytes to release tumour necrosis factor-α, interleukin-1β and interleukin-6 [PDF]
FEMS Immunology & Medical Microbiology, 1993 Cytokines play a major role in the pathophysiology of septic shock. In this study, human peripheral blood monocytes were stimulated with peptidoglycan and teichoic acid, purified from a strain of Staphylococcus epidermidis. Polymyxin B (PM-B) was added to avoid the effects of possible contamination with endotoxin.
E, Mattsson +5 more
openaire +2 more sources
Serum amyloid A primes microglia for ATP-dependent interleukin-1\u3b2 release [PDF]
, 2018 Acute-phase response is a systemic reaction to environmental/inflammatory insults and involves production of acute-phase proteins, including serum amyloid A (SAA).
A Basu +82 more
core +2 more sources
Peran IL-1 β pada Sepsis dan Gangguan Ginjal Akut Bayi Lahir Prematur
Sari Pediatri, 2020 Latar belakang. Interleukin-1β berperan dalam kejadian infeksi/inflamasi pada bayi prematur yang dapat menyebabkan gejala klinis berat. Imaturitas organ dapat menyebabkan kejadian inflamasi yang dapat merangsang pembentukan sitokin, salah satunya ...
Fiva Aprilia Kadi +3 more
doaj +1 more source
Relationship between IL-1β production and endodontic status of human periapical lesions [PDF]
Vojnosanitetski Pregled, 2017 Background/Aim. Apical periodontitis is mainly caused by bacterial infection within the root canal and periapical bone destruction which are prominent features of this lesion.
Popovska Lidija +6 more
doaj +1 more source
Dexamethasone suppresses interleukin-1β-induced human β-defensin 2 mRNA expression: involvement of p38 MAPK, JNK, MKP-1, and NF-κB transcriptional factor in A549 cells [PDF]
FEMS Immunology & Medical Microbiology, 2007 Human beta-defensin (HBD)-2 is an inducible antimicrobial peptide that plays an important role in innate immunity. Glucocorticoids, on the other hand, exert immunosuppressive and anti-inflammatory actions. We have previously reported that interleukin (IL)-1beta induces HBD-2 mRNA expression through the activation of nuclear factor-kappaB (NF-kappaB ...
Byeong-Churl Jang +4 more
openaire +3 more sources
Neurobiology of Disease, 2015 We have previously shown that increases in blood–brain barrier permeability represent an important component of ischemia–reperfusion related brain injury in the fetus.
Xiaodi Chen +12 more
doaj +1 more source