Dexamethasone suppresses interleukin-1β-induced human β-defensin 2 mRNA expression: involvement of p38 MAPK, JNK, MKP-1, and NF-κB transcriptional factor in A549 cells [PDF]
FEMS Immunology & Medical Microbiology, 2007 Human beta-defensin (HBD)-2 is an inducible antimicrobial peptide that plays an important role in innate immunity. Glucocorticoids, on the other hand, exert immunosuppressive and anti-inflammatory actions. We have previously reported that interleukin (IL)-1beta induces HBD-2 mRNA expression through the activation of nuclear factor-kappaB (NF-kappaB ...
Byeong-Churl Jang +4 more
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Neurobiology of Disease, 2015 We have previously shown that increases in blood–brain barrier permeability represent an important component of ischemia–reperfusion related brain injury in the fetus.
Xiaodi Chen +12 more
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BMC Molecular and Cell Biology, 2022 Background Acetaminophen is commonly recommended for the early analgesia of osteoarthritis. However, the molecular mechanism by which it acts remains unknown.
Jie Gao +4 more
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Metformin Inhibits the Production of Reactive Oxygen Species from NADH:Ubiquinone Oxidoreductase to Limit Induction of Interleukin-1β (IL-1β) and Boosts Interleukin-10 (IL-10) in Lipopolysaccharide (LPS)-activated Macrophages [PDF]
Journal of Biological Chemistry, 2015 Metformin, a frontline treatment for type II diabetes mellitus, decreases production of the pro-form of the inflammatory cytokine IL-1β in response to LPS in macrophages. We found that it specifically inhibited pro-IL-1β production, having no effect on TNF-α.
Beth Kelly +3 more
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Relationship between IL-1β production and endodontic status of human periapical lesions [PDF]
Vojnosanitetski Pregled, 2017 Background/Aim. Apical periodontitis is mainly caused by bacterial infection within the root canal and periapical bone destruction which are prominent features of this lesion.
Popovska Lidija +6 more
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Interleukin-1β sequesters hypoxia inducible factor 2α to the primary cilium. [PDF]
, 2013 BACKGROUND: The primary cilium coordinates signalling in development, health and disease. Previously we have shown that the cilium is essential for the anabolic response to loading and the inflammatory response to interleukin-1β (IL-1β).
Wann, AK +7 more
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Biomedical and Biotechnology Research Journal, 2022 Background: The cytokine storm and specific biochemical results were both observed during Coronavirus disease 2019 (COVID-19) infection. The aim of this study was to see if there was any correlation between biochemical findings and cytokine levels ...
Ismael Raheem Al-Muhana +3 more
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The emerging role of Interleukin 1β (IL-1β) in cancer cachexia [PDF]
, 2021 Treatment of cancer cachexia remains an unmet need. The host-tumour interface and the resulting sequestration of the pro-inflammatory cytokine Il-1β is critical in cachexia development.
Laird, Barry J +12 more
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Curcuminoids extract, hydrolyzed collagen and green tea extract synergically inhibit inflammatory and catabolic mediator's synthesis by normal bovine and osteoarthritic human chondrocytes in monolayer. [PDF]
PLoS ONE, 2015 The main objective of this study was to assess the in vitro effects of curcuminoids extract, hydrolyzed collagen and green tea extract in normal bovine chondrocytes and osteoarthritic human chondrocytes cultured in monolayer. This study also investigated
Fanny Comblain +5 more
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Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1 beta-mediated cartilage degradation [PDF]
, 2010 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
Martin M Knight +16 more
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