Results 61 to 70 of about 279,979 (283)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A Single Dose of Atorvastatin Applied Acutely after Spinal Cord Injury Suppresses Inflammation, Apoptosis, and Promotes Axon Outgrowth, Which Might Be Essential for Favorable Functional Outcome. [PDF]

, 2018
The aim of our study was to limit the inflammatory response after a spinal cord injury (SCI) using Atorvastatin (ATR), a potent inhibitor of cholesterol biosynthesis.
Bacova, Maria, Bimbova, Katarina, Fedorova, Jana, Galik, Jan, Jachova, Jana, Kisucka, Alexandra, Lukacova, Nadezda, Marsala, Martin, Papcunova, Stefania, Pavel, Jaroslav, Stropkovska, Andrea, Zavacky, Peter   +11 more
core   +5 more sources

Progestins Inhibit Interleukin-1β-Induced Matrix Metalloproteinase 1 and Interleukin 8 Expression via the Glucocorticoid Receptor in Primary Human Amnion Mesenchymal Cells

Frontiers in Physiology, 2020
Preterm premature rupture of membranes is a leading cause of preterm births. Cytokine induced matrix metalloproteinase1 and interleukin 8 production from amnion mesenchymal cells may contribute to fetal membrane weakening and rupture.
William Marinello, Liping Feng, Terrence K. Allen   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Pattern of Interleukin-17A and Interleukin-1β in Migraine Patients [PDF]

Journal of Kerman University of Medical Sciences
Background: Migraine is a complex neurological disorder. The precise etiology of migraine is not clear. Many studies have been conducted on the association of the immune system with migraine pathophysiology.
Fardin Faraji, Ghasem Mosayebi, Afsoon Talaei, Hossein Ansari, Fatemeh Rafiei, Mobina Ravanbakhsh, Mana Shojapour   +6 more
doaj   +1 more source

L-arginine abolishes the hypothalamic serotonergic activation induced by central interleukin-1 beta administration to normal rats [PDF]

, 2013
IL-1 beta-induced anorexia may depend on interactions of the cytokine with neuropeptides and neurotransmitters of the central nervous system control of energy balance and serotonin is likely to be one catabolic mediator targeted by IL-1 beta.
Andrade, Iracema Senna de, Iuras, Anderson, Nascimento, Claudia Maria da Penha Oller do, Oyama, Lila Missae, Ribeiro, Eliane Beraldi, Santos, Gianni Mara Silva dos, Silveira, Vera Lucia Flor, Telles, Monica Marques   +7 more
core   +3 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Evaluation of Interleukin 1β in Febrile Convulsion

Iranian Journal of Allergy, Asthma and Immunology, 2012
Febrile convulsion (FC) is the most common type of seizure in childhood that occurs in 2-5 % of the children younger than 6 years. Interleukin 1β (IL-1β) is a cytokine that contributes to febrile inflammatory responses.
Fatemeh Behmanesh, Farah Ashrafzadeh, Abdoreza Varasteh, Abdoreza Shakeri, Shabnam Shahsavand   +4 more
doaj  

MOLECULAR BIOLOGY ANALYSIS OF IL -1Β, IL -4, AND IL -1Β RA GENE POLYMORPHISMS IN ETHNIC BASHKIR PATIENTS WITH RHEUMATOID ARTHRITIS, LIVING IN C HELYABINSK REGION

Медицинская иммунология, 2014
. Common polymorphisms of interleukin-1β, receptor antagonist interleukin-1, and interleukin-4 genes have been studied among the patients with rheumatoid arthritis of Bashkir origin, living in Chelyabinsk Region.
A. L. Burmistrova, D. S. Stashkevich, T. A. Susslova, I. V. Devald, A. O. Issakanova, O. N. Dimcheva   +5 more
doaj   +1 more source

Education in inpatient children and young people’s mental health services [PDF]

, 2018
As a chronic disease, osteoarthritis (OA) leads to the degradation of both cartilage and subchondral bone, its development being mediated by proinflammatory cytokines like interleukin-1β.
An Liu (291211), Chiyuan Ma (702577), Haobo Wu (5463542), Jisheng Ran (713781), Kai Xu (122914), Lidong Wu (5463548), Linyan Wang (526896), Shigui Yan (734595), Wei Wang (17594), Xiaopeng Zhou (714571), Yute Yang (5463545)   +10 more
core   +5 more sources