Results 81 to 90 of about 542,868 (256)

Salmonella manipulates the host to drive pathogenicity via induction of interleukin 1β.

PLoS Biology
Acute gastrointestinal infection with intracellular pathogens like Salmonella Typhimurium triggers the release of the proinflammatory cytokine interleukin 1β (IL-1β).
Mor Zigdon, Jasmin Sawaed, Lilach Zelik, Dana Binyamin, Shira Ben-Simon, Nofar Asulin, Rachel Levin, Sonia Modilevsky, Maria Naama, Shahar Telpaz, Elad Rubin, Aya Awad, Wisal Sawaed, Sarina Harshuk-Shabso, Meital Nuriel-Ohayon, Mathumathi Krishnamohan, Michal Werbner, Omry Koren, Sebastian E Winter, Ron N Apte, Elena Voronov, Shai Bel   +21 more
doaj   +1 more source

Analysis of In Silico Interaction Campasterol of Alphitobius diaperinus with Interleukin 1β in Burn Conditions: Analisis Interaksi In silico Campasterol Kumbang Alphitobius diaperinus dengan Interleukin 1β pada Kondisi Luka Bakar

Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH)
Burns are a pathological condition that, if not managed properly, will cause wider damage. This study aims to analyze the potential of campasterol from the cage beetle Alphitobius diaperinus inhibitor IL-1β in burn conditions analyzed through in silico ...
Yossi Maryanti, Erfan Aritonang, Rahmawati Januar, Akbar Wicaksono, Yuli Susana, Detty Intan Sari, Irva Riandika, Putri Jelita Manulang, Fatmawati, Sri Wahyuni   +9 more
doaj   +1 more source

Elevated Liver Enzymes Is Not an Impediment to Allopurinol Dose Escalation: An Observational Cohort Study

Arthritis Care &Research, EarlyView.
Objective Routine liver enzyme monitoring is advocated for while on allopurinol, but supporting guidance is lacking. We assessed the incidence and factors associated with elevated liver enzyme levels in patients with gout commenced on allopurinol. Methods One hundred and fifty patients with gout and normal baseline serum aminotransferases initiated on ...
May Shuen Tang, Qai Ven Yap, Peter Pak Moon Cheung, Amelia Santosa, Gim Gee Teng   +4 more
wiley   +1 more source

High-yield soluble expression of recombinant human interleukin-1β in Escherichia coli

, 2020
The pro-inflammatory cytokine interleukin-1β (IL-1β) is a key mediator of inflammation and is implicated in the ...
Kai Zhang, Xue Zhu, Ling Zhu, Yun Gao, K E Wang, Aiping Liu, Fanfan Zhou   +6 more
core  

Development of an Interleukin-1β Vaccine in Patients with Type 2 Diabetes

, 2016
Interleukin-1β (IL-1β) is a key cytokine involved in inflammatory illnesses including rare hereditary diseases and common chronic inflammatory conditions as gout, rheumatoid arthritis, and type 2 diabetes mellitus, suggesting reduction of IL-1β activity ...
Maurer, Patrik, Saudan, P., Saudan, Philippe, Lässing, Ute, Seelig, E., Donath, M. Y., Bachmann, Martin, Spohn, Gunther, Donath, Marc Y, Osranek, Martin, Bachmann, M. F., Cavelti-Weder, Claudia, Müller, Philipp, Seelig, Eleonora, Jennings, Gary T, Timper, K., Keller, Cornelia, Timper, Katharina, Osranek, M., Willers, J., Spohn, G., Willers, Joerg, Muller, P., Jennings, G. T., Maurer, P., Lassing, U., Cavelti-Weder, C., Keller, C., Saudan P, Seelig E, Willers J, Lässing U, Jennings GT, Osranek M, Müller P, Bachmann MF, Spohn G, Cavelti-Weder C, Donath MY, Keller C, Maurer P, Timper K   +41 more
core   +1 more source

Unsupervised Machine Learning Identifies Shared Biomechanical and Clinical Variation in Individuals with Knee Osteoarthritis and High BMI: A Secondary Analysis of the IDEA Trial

Arthritis Care &Research, Accepted Article.
Objective High body mass index (BMI≥27 kg/m2) and aberrant gait biomechanics are primary risk factors for knee osteoarthritis (KOA), yet the specific loading patterns linked to clinical disease features remain unclear. Unsupervised machine learning (ML) was used to identify vertical ground reaction force (vGRF) waveform modes of variation and ...
Ashley N. Buck, J. Elyse Borgert, Hyeon Lee, Liubov Arbeeva, Yvonne M. Golightly, Richard F. Loeser, Leigh F. Callahan, Stephen P. Messier, Brian Pietrosimone, Amanda E. Nelson, James S. Marron   +10 more
wiley   +1 more source

Genetically Programmed Shape‐Morphing of Engineered Living Materials

Advanced Functional Materials, EarlyView.
Here, bacterial and mammalian engineered living materials (ELMs) are presented, in which living cells direct genetically programmed and enzymatically mediated shape‐morphing. The resulting deformation and shape‐recovery can be actuated in a genetically controlled manner by an ELM incorporating out‐of‐equilibrium counteracting biochemical reactions with
Jan Becker, Yuchen Liu, Miguel Baños, Rosanne Schmachtenberg, Mahmudul Hasan, Claudia Fink‐Straube, Luai R. Khoury, Wilfried Weber   +7 more
wiley   +1 more source

Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion

Cell Reports, 2018
Summary: IL-1β requires processing by caspase-1 to generate the active, pro-inflammatory cytokine. Acute IL-1β secretion from inflammasome-activated macrophages requires caspase-1-dependent GSDMD cleavage, which also induces pyroptosis.
Mercedes Monteleone, Amanda C. Stanley, Kaiwen W. Chen, Darren L. Brown, Jelena S. Bezbradica, Jessica B. von Pein, Caroline L. Holley, Dave Boucher, Melanie R. Shakespear, Ronan Kapetanovic, Verena Rolfes, Matthew J. Sweet, Jennifer L. Stow, Kate Schroder   +13 more
doaj   +1 more source

Interleukin-1 (IL-1) system gene expression in granulosa cells: kinetics during terminal preovulatory follicle maturation in the mare

Reproductive Biology and Endocrinology, 2003
Background A growing body of evidences suggests that the ovary is a site of inflammatory reactions, and thus, ovarian cells could represent sources and targets of the interleukin-1 (IL-1) system.
Gérard Nadine, Martoriati Alain
doaj   +1 more source

Differences in the Levels of Interleukin-1β (IL-1β) and Interleukin-1 Receptor Antagonist (IL-1ra) in Children with Status Epilepticus and Febrile Seizure [PDF]

, 2017
Proinflammatory cytokines are elevated in status epilepticus and febrile seizure and associated with tissue damage. This study aimed to investigate the differences in interleukin 1 beta (IL-1β) and interleukin 1 receptor agonist (IL-1ra) levels in status
Masdar Muid, Fita Shofiyah, Hidayat Sujuti   +2 more
core   +1 more source