Results 81 to 90 of about 516,739 (277)

Inhibition of Inflammasome-Dependent Interleukin 1β Production by Streptococcal NAD⁺-Glycohydrolase: Evidence for Extracellular Activity

mBio, 2017
Group A Streptococcus (GAS) is a common human pathogen and the etiologic agent of a large number of diseases ranging from mild, self-limiting infections to invasive life-threatening conditions.
Dóra Hancz, Elsa Westerlund, Benedicte Bastiat-Sempe, Onkar Sharma, Christine Valfridsson, Lena Meyer, John F. Love, Maghnus O’Seaghdha, Michael R. Wessels, Jenny J. Persson   +9 more
doaj   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

PENGARUH IRAMA SIRKADIAN PADA PERAN INTERLEUKIN 1β (IL-1β) DAN INTERLEUKIN 6 (IL-6) TERHADAP DIABETES MELITUS TIKUS WISTAR [PDF]

, 2020
Latar Belakang: Prevalensi diabetes melitus pada penduduk dewasa Indonesia sebesar 6,9% di tahun 2013 dan melonjak pesat ke angka 8,5% di tahun 2018.
ALYA SAHILLA FAHRI
core   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Therapy with canakinumab for gout

Научно-практическая ревматология, 2019
A significant part of patients with gout has contraindications to taking nonsteroidal anti-inflammatory drugs, colchicine and glucocorticoids. Such therapy is often ineffective, particularly in patients with the severe tophaceous gout what hampers ...
M. S. Eliseev, E. L. Nasonov
doaj   +1 more source

Distinct Roles of IL-1β and IL-18 in NLRC4-Induced Autoinflammation

Frontiers in Immunology, 2020
The NLRC4 inflammasome assembles in response to detection of bacterial invasion, and NLRC4 activation leads to the production of IL-1β and IL-18 together with pyroptosis-mediated cell death.
Yuki Sasaki, Kunihiro Otsuka, Hideki Arimochi, Shin-Ichi Tsukumo, Shin-Ichi Tsukumo, Koji Yasutomo, Koji Yasutomo, Koji Yasutomo   +7 more
doaj   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Inhibition of Interleukin 1β Signaling by Anakinra Ameliorates Proinflammatory Cytokine Responses in Zika Virus–Infected Human Blood-Brain Barrier Endothelial Cells (Letter)

, 2019
TO THE EDITOR—A recent study by He et al found that interleukin 1β (IL-1β) production during Zika virus (ZIKV) infection was driven by NLRP3 inflammasome activation [1].
Hueston, Linda, Mahalingam, Suresh, Grau, Georges E   +2 more
core   +1 more source

Serum interleukin 1β in patients with acquired laryngotracheal stenosis

Acta Otorhinolaryngologica Italica, 2022
Norazwani Azwal, Yogeswaran Lokanathan, Mawaddah Azman, Min Hwei Ng, Abdullah Sani Mohamed, Marina Mat Baki   +5 more
doaj   +1 more source