Results 71 to 80 of about 542,868 (256)

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Serum interleukin 1β in patients with acquired laryngotracheal stenosis

Acta Otorhinolaryngologica Italica, 2022
Norazwani Azwal, Yogeswaran Lokanathan, Mawaddah Azman, Min Hwei Ng, Abdullah Sani Mohamed, Marina Mat Baki   +5 more
doaj   +1 more source

Distinct Roles of IL-1β and IL-18 in NLRC4-Induced Autoinflammation

Frontiers in Immunology, 2020
The NLRC4 inflammasome assembles in response to detection of bacterial invasion, and NLRC4 activation leads to the production of IL-1β and IL-18 together with pyroptosis-mediated cell death.
Yuki Sasaki, Kunihiro Otsuka, Hideki Arimochi, Shin-Ichi Tsukumo, Shin-Ichi Tsukumo, Koji Yasutomo, Koji Yasutomo, Koji Yasutomo   +7 more
doaj   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

The role of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide and interleukin-1 stimulated enterocyte prostanoid formation

Mediators of Inflammation, 1998
Lipopolysaccharide is an inflammatory agent and interleukin-1 is a cytokine. Their pro-inflammatory effects may be mediated by prostanoids produced by inducible cyclooxygenase-2.
W. E. Longo, L. J. Damore, J. E. Mazuski, G. S. Smith, N. Panesar, D. L. Kaminski   +5 more
doaj   +1 more source

Enhanced production of nitric oxide in aortae from spontaneously hypertensive rats by interleukin-1β

, 1993
Cultured aortic smooth muscle cells from spontaneously hypertensive rats produce more nitrite than cells from Wistar-Kyoto rats in response to interleukin-1β.
Junquero, DC, Vanhoutte, PM, Schini, VB, ScottBurden, T   +3 more
core   +1 more source

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini, Giulia Tammam, Andra Ezaru, Manuela Gambella, Benoît Sanson, Luisa Villa, Michele Cavalli, Mihai‐Bogdan Ioncea, Angela Puma, Sabrina Sacconi   +9 more
wiley   +1 more source

PERBANDINGAN KADAR SERUM HEAT SHOCK PROTEIN 90 (HSP90) DAN INTERLEUKIN-1β (IL-1β) PADA PREEKLAMSIA DAN KEHAMILAN NORMAL [PDF]

, 2017
ABSTRAK PERBANDINGAN KADAR SERUM HEAT SHOCK PROTEIN 90 (HSP90) DAN INTERLEUKIN-1β (IL-1β) PADA PREEKLAMSIA DAN KEHAMILAN NORMAL INGELIA Preeklamsia merupakan komplikasi kehamilan yang menyebabkan lebih dari 25% kematian ibu di Indonesia ...
Ingelia, Ingelia
core   +1 more source

Orthodontic force, tooth movement, and interleukin-1β [PDF]

, 2017
This review presents the basic knowledge and understanding of the biological processes involved in the orthodontic force and tooth movement. It also explains one of the basic inflammatory markers that was the “interleukin-1β” (IL-1β). Because orthodontic
Luppanapornlarp, Suwannee, Iida, Junichiro   +1 more
core  

Development of a Disease Activity Index for the Assessment of VEXAS Syndrome (VEXAS‐DAI)

Arthritis Care &Research, EarlyView.
Objective Vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic syndrome (VEXAS) syndrome is characterized by a complex spectrum of inflammatory and hematologic manifestations. Clinical research to identify effective therapies is urgently needed but is hindered by the lack of validated outcome measures.
Kevin Byram, Heřman Mann, Danielle Hammond, Onima Chowdhury, Sinisa Savic, Yohei Kirino, Carmelo Gurnari, Maël Heiblig, Thibault Comont, Arsène Mekinian, Mrinal M. Patnaik, Lachelle D. Weeks, Gary Ho, Adam Al‐Hakim, Scott Goldberg, Marcela A. Ferrada, Sophie Georgin‐Lavialle, Peter C. Grayson, Emma M. Groarke, Bhavisha Patel, Megan Sullivan, Sarah A. Buckley, Bryan G. Harder, Raman Garcha, David B. Beck, Matthew J. Koster   +25 more
wiley   +1 more source