Results 181 to 190 of about 29,828,531 (204)

Lanthanum Carbonate Nanosheets Based Colloidal Hydrogel for Modulating Innate & Adaptive Tumor Immunotherapy by Augmented Cellular Pyroptosis

Advanced Science, EarlyView.
The Gela/decitabine/La2(CO3)3 colloidal (GDLC) hydrogel developed here could reverse the epigenetic silencing of the GSDME gene by the synergistic interaction between DAC and La3+, while concurrently activating caspase‐3, thus facilitating pyroptosis induction under the tumor microenvironment.
Yang Hong, Haitao Wu, Weitao Wang, Xuan Zhang, Qian Chen, Yaoyu Hu, Zhengbao Zha   +6 more
wiley   +1 more source

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

Interleukin-1 regulates myeloid cell trafficking and cerebral blood flow following intracerebral haemorrhage

Disease Models & Mechanisms
Jack Barrington, Jack Rivers-Auty, Patrick Strangward, Sabrina Tamburrano, Nikolett Lénárt, Tessa Swanton, Eloise Lemarchand, Adrian R. Parry-Jones, Ádám Dénes, David Brough, Stuart M. Allan   +10 more
doaj   +1 more source

Engineered Xenogeneic Bone Scaffold with IL‐10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair

Advanced Science, EarlyView.
A multifunctional regenerative composite is constructed by 3D‐printing thermosensitive PNIPAM hydrogel embedded with MPDA@IL‐10 nanoparticles and autologous BMSCs onto antigen‐depleted porcine bone matrix for beagle critical‐sized skull defect reconstruction.
Weihao Lv, Lei Zhang, Fei Fei, Zhibin Wu, Xiuquan Wu, Ya‐nan Dou, Yihao Fu, Hao Chang, Yujie Qiang, Huaxia Xie, Ni An, Leiying Chen, Hongchen Zhang, Min‐Wen Zheng, Hongqing Chen, Xia Li, Zhou Fei   +16 more
wiley   +1 more source

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Interleukin-6 Signaling and Anti-Interleukin-6 Therapeutics in Cardiovascular Disease

Circulation Research, 2021

exaly  

Biology and therapeutic potential of interleukin-10

Journal of Experimental Medicine, 2020
Anne O'Garra, Margarida Saraiva, Paulo Vieira   +2 more
exaly  

Interleukin-22: Immunobiology and Pathology

Annual Review of Immunology, 2015
Jarrod Dudakov, Alan Hanash
exaly  

Signaling and Function of Interleukin-2 in T Lymphocytes

Annual Review of Immunology, 2018
Sarah Ross, Doreen Cantrell
exaly  

Effects of Interleukin-1β Inhibition With Canakinumab on Hemoglobin A1c, Lipids, C-Reactive Protein, Interleukin-6, and Fibrinogen

Circulation, 2012
Tom Thurén, Peter Libby, Brendan Everett   +2 more
exaly  

Interleukin-4 and lnterleukin-13: Their Similarities and Discrepancies

International Reviews of Immunology, 1998
Jacques Banchereau, P Chomarat
exaly