Results 241 to 250 of about 814,199 (330)

Phenotypic Changes in a Monocyte Cluster with High Interleukin-1 Beta Expression during Long-Term Anti-CD20 Therapy. [PDF]

Ann Neurol
Waede M, Kingo C, Damsbo K, Joergensen MU, Oubounyt M, Gjerstorff M, Thomassen M, Baumbach J, Moeller JB, Elkjaer ML, Illes Z.   +10 more
europepmc   +1 more source

Gut Bacteria Improve Depressive Symptoms by Degrading Cortisol into Androgen

Advanced Science, EarlyView.
Chronic stress is an important risk factor for stress‐related disorders such as depression. Stress hormone cortisol is essential for the pathogenesis of stress‐related disorders such as depression. Some gut microbiota degraded cortisol, and improve depressive symptoms.
Xiong Wang, Qing Wu, Hao‐Long Zeng, Yin Shen, Hong‐Han Zhang, Jun Gong, Qi Zhang, Jia‐Zhao Xie, Da‐Wei Ye, Zi‐Yong Sun, Zhong‐Chun Liu, Li‐Ming Cheng, Di Li   +12 more
wiley   +1 more source

The <i>Arabidopsis</i> TIRome informs the design of artificial TIR (Toll/interleukin-1 receptor) domain proteins. [PDF]

Proc Natl Acad Sci U S A
Bayless AM, Song L, Sorbello M, Ogden SC, Todd TS, Flint A, Maruta N, Tulu J, Drenichev M, Ntoukakis V, Ve T, Mobli M, Wan L, Liu Q, Dangl JL, Kobe B, Grant M, Nishimura MT.   +17 more
europepmc   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Protective Effects of Interleukin-1 Inhibition With Anakinra in Mouse Models of Ischemic Stroke With and Without Reperfusion. [PDF]

J Am Heart Assoc
Chaparro-Cabanillas N, Aliena-Valero A, Pedragosa J, Pedrosa L, Honores M, Rossinyol-Boladeres M, Salom JB, Chamorro Á, Arostegui JI, Urra X, Justicia C, Planas AM.   +11 more
europepmc   +1 more source

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

Molecular docking and MD simulations predicted quercetin as a potent human interleukin-1 beta (hIL1β) inhibitor for improved endodontic disease management. [PDF]

PLoS One
Boreak N, Almasoudi SA, Alharbi A, Judayba M, Tahrei S, Eishah AA, Madkhali TA, Hattan MA, Majrashi MH, Daak HA, Hakami A.   +10 more
europepmc   +1 more source

Molecular mechanisms involved in interleukin 1-beta (IL-1β)-induced memory impairment. Modulation by alpha-melanocyte-stimulating hormone (α-MSH)

, 2013
Patricia González, I. Machado, A. Alejandro Vilcaes, Carla Caruso, German A. Roth, Helgi B. Schiöth, Mercedes Lasaga, Teresa Scimonelli   +7 more
openalex   +2 more sources

A Patient‐Derived Organ‐on‐Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer

Advanced Science, EarlyView.
Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...
Darbaz Adnan, Natan Roberto de Barros, Luca S. Santovito, Xuhong Cheng, Kristi M. Lawrence, Mariah K. Barnett, Martine D. Boetto, Neal Mehta, Ajaypal Singh, Lin Cheng, Xiangsheng Huang, Faraz Bishehsari   +11 more
wiley   +1 more source

Interleukin-1 regulates myeloid cell trafficking and cerebral blood flow following intracerebral haemorrhage.

Dis Model Mech
Barrington J, Rivers-Auty J, Strangward P, Tamburrano S, Lénárt N, Swanton T, Lemarchand E, Parry-Jones AR, Dénes Á, Brough D, Allan SM.   +10 more
europepmc   +1 more source