Results 281 to 290 of about 814,199 (330)

Impact of Interleukin-1 Blockade on the Development of Macrophage Activation Syndrome in Still Disease: Incidence and Diagnostic Validity of the EULAR/ACR/PRINTO 2016 MAS Classification Criteria. [PDF]

Arthritis Rheumatol
Erkens RGA, Rogani G, Huber L, Verwoerd A, Schonenberg-Meinema D, van den Berg JM, Armbrust W, Legger GE, Kamphuis S, Schatorjé EJH, Hoppenreijs EPAH, Swart JF, Jansen MHA, van Loosdregt J, Vastert SJ.   +14 more
europepmc   +1 more source

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

Contribution of Interleukin-1 Receptor-Associated Kinase 1 Gene Polymorphism to Systemic Lupus Erythematosus in Chinese Patients. [PDF]

J Inflamm Res
Zhao L, Xu W, Du S, Xi F, Shi X, Liu R.
europepmc   +1 more source

ETV1 Drives CD4+ T Cell‐Mediated Intestinal Inflammation in Inflammatory Bowel Disease Through Amino Acid Transporter Slc7a5

Advanced Science, EarlyView.
This study identifies the transcription factor ETV1 as a key driver of CD4⁺ T cell‐mediated intestinal inflammation in inflammatory bowel disease (IBD). ETV1 promotes CD4⁺ T cell activation, proliferation, and Th17 differentiation by activating the amino acid transporter SLC7A5, fueling metabolic reprogramming.
Yan Shi, Song Wang, Yuqing Yan, Wei Chen, Yingying Cao, Dafan Chen, Wei Chen, Caiyun Ma, Xinjian Wan   +8 more
wiley   +1 more source

FL/FLT3 signaling enhances mechanical pain hypersensitivity through Interleukin-1 beta (IL-1β) in male mice. [PDF]

Neurobiol Pain
Sonrier C, Sar C, Melo I, Dioufoulet L, Lucena-Silva GV, Mallié S, Bertin J, Leyris JP, Ango F, Cunha TM, Ou Maati HM, Valmier J, Rivat C, Méchaly I.   +13 more
europepmc   +1 more source

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

Advanced Science, EarlyView.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar, Vishwa I. P. W. A. Kumara, Pradeepa C. G. Bandaranayake, Dong Yawen, Yang‐Yang Gao, Junfeng Liu, Ge‐Fei Hao, Xiu‐Fang Xin   +7 more
wiley   +1 more source

Efficacy and Safety of Zabedosertib, an Interleukin-1 Receptor-Associated Kinase 4 Inhibitor, in Patients with Moderate-to-Severe Atopic Dermatitis: A Phase II Randomized Study. [PDF]

Dermatol Ther (Heidelb)
Jodl SJ, Worm M, Friedrichs F, Heinzel-Pleines U, Wagenfeld A, Feldmüller M, Klein S, Zhang R, Shakery K, Holzmann RD, Rohde B, Perera V.   +11 more
europepmc   +1 more source

Production of interleukin-1 by mononuclear cells of newborns and their mothers.

, 1987
Hanna Bessler, Lea Sirota, F. Dulitzky, M Djaldetti   +3 more
openalex   +1 more source

N-acetylcysteine reduces the hepatic complications of social isolation stress through modulation of interleukin 1 and 6 gene expression and liver enzymes in mice. [PDF]

Sci Rep
Asgharzadeh J, Derakhshan L, Asgharzadeh N, Mardani M, Shahrani D, Shahrani M, Shahrani Korrani M.   +6 more
europepmc   +1 more source

The Impact of Two Cordless Retraction Materials on Inflammatory Biomarkers Interleukin-1 Beta and Tumor Necrosis Factor-Alpha in Gingival Crevicular Fluid: An In-Vivo Study. [PDF]

Cureus
Pidaparthi S, Krishna Kishore K, Surapaneni H, Madhavarapu NP, Sultana N, Adavikatla S, Gupta S.   +6 more
europepmc   +1 more source