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Expanding Role of Interleukin-1 Family Cytokines in Acute Ischemic Stroke. [PDF]

open access: yesInt J Mol Sci
Matys P   +6 more
europepmc   +1 more source

The Arabidopsis TIRome informs the design of artificial TIR (Toll/interleukin-1 receptor) domain proteins

open access: yes
Bayless AM   +17 more
europepmc   +1 more source
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Interleukin-1

The International Journal of Biochemistry & Cell Biology, 1998
Interleukin 1 (IL1) is a primary regulator of inflammatory and immune responses. Via its type I receptor it activates specific protein kinases, including the NF kappa B inducing kinase (NIK) and three distinct mitogen-activated protein (MAP) kinase cascades.
E, Stylianou, J, Saklatvala
openaire   +3 more sources

Interleukin 1

Archives of Dermatology, 1989
The last decade has witnessed a remarkable expansion in the understanding of the skin as an immunologic organ. A prime example of this is the discovery that keratinocytes can synthesize and secrete immunoregulatory and proinflammatory glycoproteins termed cytokines.
openaire   +4 more sources

Interleukin-1 and Interleukin-1 Fragments as Vaccine Adjuvants

Methods, 1999
The human interleukin-1beta (IL-1beta) domain in position 163-171, comprising the amino acids VQGEESNDK, has been synthesized as a nine-amino-acid-long peptide and used in vivo as a nontoxic HCl salt. The IL-1beta nonapeptide reproduces the immunostimulatory and adjuvant effects of the whole mature IL-1beta, but does not possess any of the IL-1beta ...
D, Boraschi, A, Tagliabue
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Interleukin-1

Cytokine & Growth Factor Reviews, 1984
For the past 30 years, considerable experimentation on the mechanisms of host responses to infection has centered on soluble products derived from phagocytic cells. The biologic activities of some of these products include fever mediated by endogenous pyrogen (EP) and induction of acute-phase responses by leukocytic endogenous mediator (LEM), EP and ...
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Interleukin-1, Interleukin-1 Receptors and Interleukin-1 Receptor Antagonist

International Reviews of Immunology, 1998
IL-1 (IL-1 alpha or IL-1 beta) is the prototypic "multifunctional" cytokine. Unlike the lymphocyte and colony stimulating growth factors, IL-1 affects nearly every cell type, and often in concert with other cytokines or small mediator molecules. Although some lymphocyte and colony stimulating growth factors may be therapeutically useful, IL-1 is a ...
openaire   +2 more sources

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