Results 301 to 310 of about 814,199 (330)
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1995
Abstract The human type I IL-1 receptor is predicted from the cDNA sequence to be a protein of 569 amino acids (GenBank accession number M27492; mouse, M20658; rat, M95578; chicken, M81846) (Sims et al. 1989). It contains a 20-aminoacid signal peptide, an extracellular region of 317 amino acids, a single 22-amino-acid transmembrane ...
J E, Sims, S K, Dower
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Abstract The human type I IL-1 receptor is predicted from the cDNA sequence to be a protein of 569 amino acids (GenBank accession number M27492; mouse, M20658; rat, M95578; chicken, M81846) (Sims et al. 1989). It contains a 20-aminoacid signal peptide, an extracellular region of 317 amino acids, a single 22-amino-acid transmembrane ...
J E, Sims, S K, Dower
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Schweizerische medizinische Wochenschrift, 1986
Interleukin-1 (IL-1) is secreted by macrophages, macrophage-like cells (e.g. Langerhans cells) and by astrocytes, keratinocytes, fibroblasts or natural killer cells. IL-1 is directly involved in the activation of helper T lymphocytes. However, it has been shown that IL-1 also induces release of collagenase and prostaglandins by fibroblasts. Furthermore,
Charles A. Dinarello, Joseph G. Cannon
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Interleukin-1 (IL-1) is secreted by macrophages, macrophage-like cells (e.g. Langerhans cells) and by astrocytes, keratinocytes, fibroblasts or natural killer cells. IL-1 is directly involved in the activation of helper T lymphocytes. However, it has been shown that IL-1 also induces release of collagenase and prostaglandins by fibroblasts. Furthermore,
Charles A. Dinarello, Joseph G. Cannon
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Immunology Today, 1989
The diverse biological activities of interleukin 1 (IL-1) have attracted interest from a wide range of biological disciplines ~ After systemic injection into a variety of animals, it seems that IL-1 affects nearly every organ system. Interested parties fall into two groups: those studying the potential beneficial effects of IL-1 on host defense ...
C A, Dinarello +4 more
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The diverse biological activities of interleukin 1 (IL-1) have attracted interest from a wide range of biological disciplines ~ After systemic injection into a variety of animals, it seems that IL-1 affects nearly every organ system. Interested parties fall into two groups: those studying the potential beneficial effects of IL-1 on host defense ...
C A, Dinarello +4 more
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Interleukin-1 and interleukin-1 receptor antagonist.
Nutrition (Burbank, Los Angeles County, Calif.), 1996Cytokines are produced in disease or during immunologic challenge. Some cytokines increase host resistance to disease whereas others trigger inflammatory processes. Interleukin 1 (IL-1) and tumor necrosis factor (TNF) are pro-inflammatory cytokines that affect nearly every cell either alone or in a synergistic fashion.
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The FASEB Journal, 1988
Interleukin 1 (IL 1) is a polypeptide that is produced after infection, injury, or antigenic challenge. Although the macrophage is a primary source of IL 1, epidermal, epithelial, lymphoid, and vascular tissues synthesize IL 1.
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Interleukin 1 (IL 1) is a polypeptide that is produced after infection, injury, or antigenic challenge. Although the macrophage is a primary source of IL 1, epidermal, epithelial, lymphoid, and vascular tissues synthesize IL 1.
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Interleukin-1 and hematopoiesis
Blood Reviews, 1989Interleukin-1 alpha and interleukin-1 beta are 17.5 kDa peptides which exert a wide variety of biological activities. Both forms of interleukin bind to a common 60-70 kDa receptor expressed by most somatic cells. One major effect of interleukin-1 is to induce the expression of other genes, including genes for other interleukins (IL-6), colony ...
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Interleukin-1 signal transduction
International Journal of Clinical and Laboratory Research, 1995Interleukin 1 (IL1) is a potent pro-inflammatory cytokine which has been implicated in the pathogenesis of chronic inflammatory disease. Despite much effect, the signal transduction pathway activated by IL1 has remained obscure. Recently, much attention has focussed on IL1 receptors and early events triggered by IL1 in cells, including activation of ...
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The interleukin-1/interleukin-1-receptor interaction
Annales de l'Institut Pasteur / Immunologie, 1987H R, MacDonald, J W, Lowenthal
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