Results 351 to 360 of about 24,572,041 (402)
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Interleukin 1 alpha and an interleukin 1 beta fragment are somnogenic
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1990The somnogenic activity of interleukin 1 beta (IL-1 beta) has previously been established. Interleukin 1 alpha (IL-1 alpha) is a distinct gene product that possesses similar biological activities. We report here that IL-1 alpha, like IL-1 beta, has the capacity in rabbits to enhance non-rapid-eye-movement sleep, electroencephalographic slow-wave (0.5 ...
Ferenc Obál +7 more
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Activation of T cells by interleukin 1 involves internalization of interleukin 1
Lymphokine research, 1989The cytokine interleukin-1 plays an important role in the induction of IL-2 secretion and IL-2 receptor expression. The events that follow binding of IL-1 to its receptor are not known. We found that in a purified T cell population (comprising the Lyt2- and L3T4- T cells) IL-1 in the absence of antigen or mitogen induced strong proliferation and de ...
Falk, Werner +2 more
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Interleukin‐1 in reproductive strategies
Evolution & Development, 2008SUMMARY Evolutionary studies on different classes of vertebrates could help clarify the role of cytokines in acceptance of the embryo by the maternal tissues. This review focuses on the cytokine interleukin‐1 (IL‐1) and reports on its presence in the female reproductive tract of species with different reproductive strategies, that is, viviparity,
Ricci, Luana +4 more
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Neuroendocrinology of Interleukin-1
1990Inflammatory processes and infectious diseases induce a constellation of host responses referred to as acute phase response (1,2). These responses include changes in immunologic, metabolic, neurologic, and endocrinologic functions. Although many of its components are far from being understood, it is generally believed that the acute phase response ...
Frank Berkenbosch +3 more
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Interleukin-1 and hematopoiesis
Blood Reviews, 1989Interleukin-1 alpha and interleukin-1 beta are 17.5 kDa peptides which exert a wide variety of biological activities. Both forms of interleukin bind to a common 60-70 kDa receptor expressed by most somatic cells. One major effect of interleukin-1 is to induce the expression of other genes, including genes for other interleukins (IL-6), colony ...
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Minireview Interleukin-1 and osteoarthritis
Life Sciences, 1987Il-1, a multifunctional monokine, can stimulate both synoviocytes and articular chondrocytes to release neutral proteases and prostaglandin E2. It is also capable of promoting bone resorption. Therefore, this molecule (or family of molecules) is likely to play an important role in the mechanism of articular cartilage destruction that occurs in ...
G. Loyau, J.-P. Pujol
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Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme.
Science, 1995The interleukin-1 beta (IL-1 beta) converting enzyme (ICE) processes the inactive IL-1 beta precursor to the proinflammatory cytokine. Adherent monocytes from mice harboring a disrupted ICE gene (ICE-/-) did not export IL-1 beta or interleukin-1 alpha ...
K. Kuida +6 more
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Biochemical and Biophysical Research Communications, 1992
This paper presents evidence to suggest that interleukin-1 alpha as a complex with its receptor is able to express DNA binding activity. Both the interleukin-1/receptor complex and the interleukin-1 receptor appear to be able to bind to DNA, however interleukin-1 on its own showed no binding activity. Interleukin-1 was found to be internalised into the
M.Neale Weitzmann, Nerina Savage
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This paper presents evidence to suggest that interleukin-1 alpha as a complex with its receptor is able to express DNA binding activity. Both the interleukin-1/receptor complex and the interleukin-1 receptor appear to be able to bind to DNA, however interleukin-1 on its own showed no binding activity. Interleukin-1 was found to be internalised into the
M.Neale Weitzmann, Nerina Savage
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1985
Publisher Summary This chapter describes the basic protocols for the production and purification of IL-1 from the P388D 1 macrophage cell line, along with assays used to quantitate IL-1 activity. A basic protocol for generating goat antibodies to IL-1 is also explained.
Steven B. Mizel, Mitchell Dukovich
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Publisher Summary This chapter describes the basic protocols for the production and purification of IL-1 from the P388D 1 macrophage cell line, along with assays used to quantitate IL-1 activity. A basic protocol for generating goat antibodies to IL-1 is also explained.
Steven B. Mizel, Mitchell Dukovich
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Science, 1996
Despite the allegations being made in the Cistron vs. Immunex case (E. Marshall, News & Comment, [30 Aug., p. 1162][1]), and despite the obvious irregularities of peer review and research reporting that permeate the whole matter, there remains an undeniable fact—rank and file scientists at ...
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Despite the allegations being made in the Cistron vs. Immunex case (E. Marshall, News & Comment, [30 Aug., p. 1162][1]), and despite the obvious irregularities of peer review and research reporting that permeate the whole matter, there remains an undeniable fact—rank and file scientists at ...
openaire +2 more sources