Results 71 to 80 of about 24,572,041 (402)

Recognition of Lipoproteins by Toll-like Receptor 2 and DNA by the AIM2 Inflammasome Is Responsible for Production of Interleukin-1β by Virulent Suilysin-Negative Streptococcus suis Serotype 2

Pathogens, 2020
Streptococcus suis serotype 2 is an important porcine bacterial pathogen and zoonotic agent causing sudden death, septic shock and meningitis. These pathologies are the consequence of an exacerbated inflammatory response composed of various mediators ...
Agustina Lavagna, Jean-Philippe Auger, Stephen E. Giradin, Nicolas Gisch, Mariela Segura, Marcelo Gottschalk   +5 more
doaj   +1 more source

Interleukin-1 and Nuclear Factor Kappa B Signaling Promote Breast Cancer Progression and Treatment Resistance

Cells, 2022
While meant for wound healing and immunity in response to injury and infection, inflammatory signaling is usurped by cancerous tumors to promote disease progression, including treatment resistance.
Sydney Diep, Mahita Maddukuri, Stephanie Yamauchi, Ganamee Geshow, Nikki A. Delk   +4 more
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Neonatal-onset multisystem inflammatory disease responsive to interleukin-1 beta inhibition [PDF]

, 2006
BACKGROUND:Neonatal-onset multisystem inflammatory disease is characterized by fever, urticarial rash, aseptic meningitis, deforming arthropathy, hearing loss, and mental retardation.
Adams, BS, Aksentijevich, I, Beitz, LO, Brewer, C, Butman, JA, Canna, SW, Cole, JL, Dailey, NJ, Fuhlbrigge, RC, Gardner, G, Gelabert, A, Goldbach-Mansky, R, Hannan, WP, Haverkamp, MH, Hawkins, PN, Hill, S, Hoffmann, SC, Holland, SM, Horn, W, Jarvis, JN, Jones, J, Karp, BI, Kastner, DL, Kim, HJ, Moore, TL, O'Neil, K, Paul, SM, Penzak, SR, Pham, TH, Pucino, F, Rubin, BI, Shaham, B, Snyder, C, Stein, L, Turner, ML, Vehe, RK, Warren, RW, Wesley, RA, Wiggs, E, Zalewski, C   +39 more
core  

The primary cilium influences interleukin-1 beta-induced NF kappa B signalling by regulating IKK activity [PDF]

, 2014
The primary cilium is an organelle acting as a master regulator of cellular signalling. We have previously shown that disruption of primary cilia assembly, through targeting intraflagellar transport, is associated with muted nitric oxide and ...
A.K.T. Wann, Acunzo, Alford, Amin, Amin, Baeuerle, Baeuerle, Baeuerle, Besschetnova, Boehm, Bracken, Cheong, Clement, Corbit, Corbit, Crepieux, Crowe, DiDonato, Dodd, Dossumbekova, Gao, Gerdes, Griscavage, Hatakeyama, Haycraft, Hoffmann, Huber, J.P. Chapple, Jones, Jones, Kammanadiminti, Karsdal, Lambrecht, Lancaster, Lattke, M.M. Knight, Martel-Pelletier, McGlashan, McMurray, Nauli, Oeckinghaus, Parcellier, Park, Pearle, Plummer, Rohatgi, Saklatvala, Saklatvala, Schmidts, Schneider, Shim, Shiota, Simons, Smith, Takaki, Taulman, Tazawa, Tran, Vezina, Wann, Wann, Wann, Werner, Whitfield, Williams, Windheim, Wu, Zhao, Zhu   +68 more
core   +1 more source

Interleukin-1 receptor antagonist competitively inhibits the binding of interleukin-1 to the type II interleukin-1 receptor [PDF]

Journal of Biological Chemistry, 1991
The interleukin-1 receptor antagonist (IL-1ra) inhibits the binding of interleukin-1 (IL-1) to T-cell lines possessing the type I IL-1 receptor; evidence has been published (Carter, D. B., Deibel, M. R. J., Dunn, C. J., Tomich, C. S., Laborde, A. L., Slightom, J. L., Berger, A. E., Bienkowski, M. J., Sun, F. F., McEwan, R. N., Harris, P. K. W., Yem, A.
Eric V. Granowitz, Javier Mancilla, Charles A. Dinarello, Barton D. Clark   +3 more
openaire   +2 more sources

The P2X7 Receptor-Interleukin-1 Liaison

Frontiers in Pharmacology, 2017
Interleukin-1β (IL-1β) plays a central role in stimulation of innate immune system and inflammation and in several chronic inflammatory diseases. These include rare hereditary conditions, e.g., auto-inflammatory syndromes, as well as common pathologies ...
A. Giuliani, A. Sarti, S. Falzoni, F. Di Virgilio   +3 more
semanticscholar   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Post-transcriptional inhibition of the interleukin-1 binding protein B15R of Vaccinia virus after coexpression of the related T1 protein [PDF]

, 1995
The interleukin-1 binding B15R protein of Vaccinia virus and murine T1 are related extracellular glycoproteins with similarity to the extracellular domain of interleukin-1 receptors.
Danescu, Joana, Werenskiold, Anne Katrin
core   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source