Results 51 to 60 of about 28,282,310 (344)

Interleukin-1 receptor antagonist levels predict favorable outcome after bermekimab, a first-in-class true human interleukin-1α antibody, in a phase III randomized study of advanced colorectal cancer

OncoImmunology, 2019
Bermekimab is a true human monoclonal antibody that targets interleukin-1alpa (IL-1α), an inflammation-mediating alarmin. IL-1 receptor antagonist (IL-1Ra) is a natural molecule that blocks IL-1α activity by occupying the IL-1 receptor.
Razelle Kurzrock, Tamas Hickish, Lucjan Wyrwicz, Mark Saunders, Qian Wu, Michael Stecher, Prasant Mohanty, Charles A. Dinarello, John Simard   +8 more
doaj   +1 more source

Serum interleukin 1 and interleukin 10 levels in Iraqi leukemic patients with hepatitis G virus infection.

مجلة كلية الطب, 2013
Background: Objectives : This prospective   study aimed to  estimate interleukins 1 and 10  levels in acute  hepatitis (G) in Iraqi patients with leukemiaHepatitis G virus and GB virus C (GBV-C)  RNA viruses that were independently identified in 1995,
Muhammad M. Alani
doaj   +1 more source

Respiratory Impairment Predicts Response to IL-1 and IL-6 Blockade in COVID-19 Patients With Severe Pneumonia and Hyper-Inflammation

Frontiers in Immunology, 2021
BackgroundRestraining maladaptive inflammation is considered a rationale strategy to treat severe coronavirus disease-19 (COVID-19) but available studies with selective inhibitors of pro-inflammatory cytokines have not provided unequivocal evidence of ...
Emanuel Della-Torre, Emanuel Della-Torre, Marco Lanzillotta, Corrado Campochiaro, Corrado Campochiaro, Giulio Cavalli, Giulio Cavalli, Giacomo De Luca, Giacomo De Luca, Alessandro Tomelleri, Alessandro Tomelleri, Nicola Boffini, Nicola Boffini, Rebecca De Lorenzo, Annalisa Ruggeri, Annalisa Ruggeri, Patrizia Rovere-Querini, Patrizia Rovere-Querini, Antonella Castagna, Antonella Castagna, Giovanni Landoni, Giovanni Landoni, Moreno Tresoldi, Fabio Ciceri, Fabio Ciceri, Alberto Zangrillo, Alberto Zangrillo, Lorenzo Dagna, Lorenzo Dagna   +28 more
doaj   +1 more source

Ciprofloxacin reduces the stimulation of prostaglandin E2 output by interleukin-1 in human tendon-derived cells [PDF]

, 2003
Fluoroquinolone antibiotics such as ciprofloxacin can induce tendon pathology and have various effects on tendon-derived cells in culture. We are investigating whether ciprofloxacin modifies signalling responses in tendon cells.
Corps, AN, Curry, VA, Dutt, D, Harrall, RL, Hazleman, BL, Riley, GP   +5 more
core   +1 more source

Contributions of Interleukin-1 Receptor Signaling in Traumatic Brain Injury

Frontiers in Behavioral Neuroscience, 2020
Traumatic brain injury (TBI) in various forms affects millions in the United States annually. There are currently no FDA-approved therapies for acute injury or the chronic comorbidities associated with TBI.
Jason G. Thome, Evan L. Reeder, Sean M. Collins, Poornima Gopalan, Matthew J. Robson   +4 more
doaj   +1 more source

Interleukin 1-β, Interleukin-1 Receptor Antagonist, and Interleukin 18 in Children with Acute Spontaneous Urticaria [PDF]

, 2013
Very little is known about the role of interleukin-1β (IL-1β) and interleukin-18 (IL-18) in urticaria. Material and Methods. Serum levels of IL-1β, IL-1 receptor antagonist (IL-1RA), and IL-18 were measured in 56 children with urticaria and in 41 healthy
A. Kasperska-Zając, B. Mazur, E. Machura, M. Barć-Czarnecka, M. Szczepańska   +4 more
core   +1 more source

Targeting interleukin-22 for cancer therapy

Human Vaccines & Immunotherapeutics, 2018
Interleukin-22 (IL-22) is a member of IL-10 family of cytokines. IL-22 induces proliferative and anti-apoptotic signaling pathways and production of anti-microbial molecules that enhance tissue regeneration and host defense.
Anamarija Markota, Stefan Endres, Sebastian Kobold   +2 more
doaj   +1 more source

What Is IL-1 for? The Functions of Interleukin-1 Across Evolution

Frontiers in Immunology, 2022
Interleukin-1 is a cytokine with potent inflammatory and immune-amplifying effects, mainly produced by macrophages during defensive reactions. In mammals, IL-1 is a superfamily of eleven structurally similar proteins, all involved in inflammation or its ...
Diana Boraschi, Diana Boraschi, Diana Boraschi   +2 more
doaj   +1 more source

Microglia and CNS Interleukin-1: Beyond Immunological Concepts

Frontiers in Neurology, 2018
Activation of microglia and expression of the inflammatory cytokine interleukin-1 (IL-1) in the CNS have become almost synonymous with neuroinflammation.
Xiaoyu Liu, N. Quan
semanticscholar   +1 more source

Interleukin-1 blockade in recently decompensated systolic heart failure: study design of the recently decompensated heart failure anakinra response trial (RED-HART) [PDF]

, 2015
Heart Failure (HF) is a clinical syndrome characterized by dyspnea, fatigue, and poor exercise capacity due to impaired cardiac function. The incidence of HF is increasing and represents the leading cause of hospitalization in the United States among ...
Abbate Antonio, Abouzaki Nayef, Arena Ross, BIONDI ZOCCAI, GIUSEPPE, Canada Justin, CARBONE, SALVATORE, Oddi Erdle Claudia, Valle Raleigh Juan, Van Tassell Benjamin W   +8 more
core   +1 more source