Results 211 to 220 of about 633,289 (295)

Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism

Advanced Science, EarlyView.
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang, Hengxiang Zhang, Yuqi Zhou, Chunying Li, Weinan Guo   +4 more
wiley   +1 more source

Giardia increases macrophage production of the anti-inflammatory cytokine interleukin-10 in response to lipopolysaccharide via macrophage galactose binding lectin. [PDF]

Immunohorizons
Angelova VV, Kosile RT, Darmadi M, Miskovsky EG, Fink MY, Menegas S, Wexelblatt H, Singer SM.   +7 more
europepmc   +1 more source

Elevated Interleukin-10-to-Interleukin-12 Ratio in Feline Immunodeficiency Virus-Infected Cats Predicts Loss of Type 1 Immunity to Toxoplasma gondii

, 1998
Julie K. Levy, Jerry W. Ritchey, James B. Rottman, Michael G. Davidson, Yanhua Liang, Holly L. Jordan, W. A. F. Tompkins, Mary B. Tompkins   +7 more
openalex   +1 more source

Cinobufagin Directly Targets PDE4D to Disrupt Fibroblast–Dendritic Cell Crosstalk in Atopic Dermatitis

Advanced Science, EarlyView.
Single‐cell RNA sequencing revealed that MIF signaling drives inflammatory fibroblastmyeloid cell crosstalk in atopic dermatitis. Cinobufagin, a potent PDE4D inhibitor, suppresses MIF and reduces inflammation by restoring the cAMP/PKA/CREB pathway. Genetic knockout validates PDE4D as a key driver and promising therapeutic target for atopic dermatitis ...
Shicong Li, Dihui Xu, Chenyang Zhang, Chunxiu Xiao, Meng Yu, Jiaojiao Wang, Wenyuan Wu, Xiang Lv, Dongping Yuan, Liang Zhang, Min Hong, Jing Zhou, Yang Sun, Hongyue Ma, Yuyu Zhu   +14 more
wiley   +1 more source

Increased protein expression of interleukin-10 and its signalling molecules in colon cancer progression: potential prognostic and therapeutic targets. [PDF]

Discov Oncol
Aslam A, Refaat B, Almaimani RA, Obaid AA, Mujalli A, Farrash WF, Elzubier ME, Idris S, Salaka A, Almalki AH, Alkhaldi MY, Asiri HA, Baqassi MA, Alhanash AM, Hakmi OM, Minshawi F.   +15 more
europepmc   +1 more source

A Peripheral Mechanism of Depression: Disturbed Intestinal Epithelial Per2 Gene Expression Causes Depressive Behaviors in Mice with Circadian Rhythm Disruption via Gut Barrier Damage and Microbiota Dysbiosis

Advanced Science, EarlyView.
Circardian rhythm disorder (CRD) causes abnormal expression of intestinal Period 2 (Per2) gene, which compromising intestinal barrier integrity and altering the gut microenvironment. Microbiota dysbiosis and aberrant metabolites production drive central inflammation, impair neurogenesis, and promote functional deficits, ultimately facilitating the ...
Huiliang Zhang, Xuan Qin, Haiyue Song, Jieru Zhou, Hui Wei, Lun Zhang, Yi Liu, Zhuoqun Wang, Yiren Zhang, Yiwen Lai, Jiayu Yang, Wenting Hu, Zhongshan Chen, Ji Zeng, Yu Jin, Xiaochuan Wang, Rong Liu   +16 more
wiley   +1 more source

Hypertrophic heart failure promotes gut dysbiosis and gut leakage in interleukin 10-deficient mice. [PDF]

Am J Physiol Heart Circ Physiol
Ranjan P, Goswami SK, Dutta RK, Colin K, Pal HC, Zhang Q, Lal H, Prasad R, Verma SK.   +8 more
europepmc   +1 more source

Subventricular Zone‐on‐a‐Chip: A Model to Study Neurogenesis Disruption in Neonatal Intraventricular Hemorrhage

Advanced Science, EarlyView.
A human subventricular zone‐on‐a‐chip is developed to model intraventricular hemorrhage (IVH) in preterm infants. This platform enables the study of inflammation‐driven neurogenic disruption. Exposure to hemorrhagic cerebrospinal fluid and red blood cell lysate activated inflammatory pathways, with IL1B emerging as a key mediator.
Laura Nicoleti Zamproni, Begüm Gökçe, Magnus Gram, Coco Holliday, Aylin Sendemir, Marimélia Aparecida Porcionatto, Anna Herland   +6 more
wiley   +1 more source

Incorporating Circulating Plasma Interleukin-10 Enhanced Risk Predictability of Mortality in Acute Type A Aortic Dissection Surgery. [PDF]

Rev Cardiovasc Med
Diao YF, Chen ZB, Gu JX, Xu XY, Lin WF, Yuan CZ, Xiong JQ, Li MH, Ni BQ, Zhao S, Shao YF, Zhang YY, Liu H.   +12 more
europepmc   +1 more source

Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

Advanced Science, EarlyView.
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin, Xiaofan Xiong, Yan Zhang, Siyu Zhang, Shuting Zhang, Yu Yang, Yingxue Liang, Lulu Zang, Xi Chen, Wenjuan Li, Issam Halalmeh, Rui Zhou, Zongfang Li, Haowen Liu, Jing Geng   +14 more
wiley   +1 more source