Results 121 to 130 of about 76,840 (266)

Safety, Tolerability, and Pharmacokinetics of Benralizumab: A Phase 1, Randomized, Single-Blind Study of Healthy Chinese Participants

Drug Design, Development and Therapy, 2023
Tommy Tsang Cheung,1,* Tu H Mai,2,* Yen Lin Chia,2 Desmond YH Yap,1 Chi-Ho Lee,1 Cecil Chi-Keung Chen,2 Ying Huang,3 Yuwen Jin,3 James Johnston,4 Viktoria Werkström,5 Yuhui Yao,6 Xiaoyun Ge,7 Wenying Zheng8 1Department of Medicine, Queen Mary ...
Cheung TT, Mai TH, Chia YL, Yap DYH, Lee CH, Chen CC, Huang Y, Jin Y, Johnston J, Werkström V, Yao Y, Ge X, Zheng W   +12 more
doaj  

Harnessing blood clot as a native scaffold for orchestrating tissue repairs and regeneration

BMEMat, EarlyView.
The blood clot, owing to its dynamic composition and unique microenvironment, holds significant yet underappreciated potential for tissue engineering. This review systematically summarizes the pathophysiology of clot formation, the key regulatory factors shaping its microenvironment, and its applications in both pre‐clinical and clinical settings ...
Gao‐peng Dang, Yu‐zhu Wang, Yi‐fei Wang, Que Bai, Jia‐xin Hao, Zhi‐ting Li, Xiao‐qing Cao, Yu Wei, Yue Feng, Ji‐hua Chen, Franklin R. Tay, Rui‐bing Wang, Jun‐ting Gu, Li‐na Niu   +13 more
wiley   +1 more source

Purification and characterization of heterologously produced cannabinoid receptor 1 and G proteins [PDF]

, 2007
G protein coupled receptors form the largest group of transmembrane proteins, which are involved in signal transduction and are targeted directly or indirectly by 40-50% of the drugs in the market.
Chillakuri, Chandramouli, Chillakuri, C.
core  

Association Between Genetic Variants on Chromosome 15q25 Locus and Objective Measures of Tobacco Exposure [PDF]

, 2012
Background: Two single-nucleotide polymorphisms, rs1051730 and rs16969968, located within the nicotinic acetylcholine receptor gene cluster on chromosome 15q25 locus, are associated with heaviness of smoking, risk for lung cancer, and other smoking ...
Timpson, NJ, Upton, Mark N, Johnstone, Elaine, Vineis, Paolo, Morris, Richard W, Johnson, Paul C. D., Johnson, P.C.D., Uhl, GR, Amuzu, A., Aveyard, P., Munafò, Marcus R., Sattar, N, Watt, G., Walther, Donna, Ebrahim, S, Timofeeva, M.N., Hingorani, AD, Upton, M.N., Morris, Richard W., Johnson, PC, Riboli, E., Munafò, Marcus R, Watt, Graham, Ebrahim, Shah, Relton, C., Jefferis, BJ, Timofeeva, Maria N., Casas, Juan P., Riboli, E, Riboli, Elio, Padmanabhan, S., Palmer, T.M., Prieto-Merino, D, Jefferis, Barbara J., Vineis, P., Munafo, M.R., Amuzu, Antoinette, Prieto-Merino, D., ?, ?, Brennan, P., Hingorani, Aroon D, Padmanabhan, Sandosh, Uhl, G.R., Morris, RW, Uhl, George R, Prieto-Merino, David, Johnson, Paul CD, Timpson, Nicholas J., Whincup, PH, Whincup, P.H., Palmer, Tom M, Johnstone, E.C., Sattar, N., Johnstone, Elaine C., Johnson, Paul C D, Hingorani, A.D., Jefferis, B.J., Brennan, P, Upton, Mark N., Davey Smith, George, Upton, MN, EPIC Study Group, Ebrahim, S., Davey Smith, G, Jefferis, Barbara J, Whincup, Peter H, Uhl, George R., Timofeeva, MN, Timofeeva, Maria N, Aveyard, P, Timpson, Nicholas J, Relton, Caroline, Sattar, Naveed, Casas, Juan P, Amuzu, A, Brennan, Paul, Munafò, MR, Palmer, TM, Relton, C, Walther, D., Vineis, P, Timpson, N.J., Watt, G, Hingorani, Aroon D., Casas, JP, Johnstone, Elaine C, Padmanabhan, S, Casas, J.P., Davey Smith, G., Palmer, Tom M., Johnstone, EC, Walther, D, Whincup, Peter H., Morris, R.W., Aveyard, Paul   +94 more
core   +1 more source

Growth, serum biochemical, digestive enzyme activities, antioxidant, lipid metabolism and inflammation responses of juvenile hybrid snakehead (Channa maculata♀× Channa argus♂) fed diets with different dietary lipid levels

Aquaculture Reports
The study investigated the effects of different dietary lipid levels on the growth, serum biochemical, digestive enzyme activities, antioxidant, lipid metabolism and inflammation responses of juvenile hybrid snakehead (Channa maculata♀×Channa argus ...
Yuwan Li, Wenqing Huang, Kai Peng, Junru Hu, Huijie Lu, Guoxia Wang   +5 more
doaj   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Characterization of CD123 expression by mast cells in systemic mastocytosis with multicolor flow cytometry

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Systemic mastocytosis (SM) is a clonal mast cell (MC) disorder characterized by aberrant immunophenotypes, including expression of CD25, CD2, and occasionally CD30. CD123, the α‐subunit of the interleukin‐3 receptor, is a therapeutic target in hematologic malignancies and has been reported to be expressed on neoplastic MCs by ...
Ryan C. Shean, Tracy I. George, David P. Ng   +2 more
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Serum NF-κB-Regulated Biomarkers of Proliferative Lupus Nephritis

Glomerular Diseases
Introduction: Lupus nephritis (LN) is kidney inflammation that commonly occurs from systemic lupus erythematosus. NF-κB activity is increased in LN patients, leading to elevated circulating concentrations of immune modulators that contribute ...
Nicholas A. Shoctor, Makayla P. Brady, Rebecca R. Lightman, Kristen N. Overton, Shweta Tandon, Steven P. Mathis, Madhavi J. Rane, Michelle T. Barati, Cristina G. Arriens, David W. Powell, Dawn J. Caster   +10 more
doaj   +1 more source

Causal correlations between inflammatory proteins and heart failure: A two‐sample Mendelian randomization analysis

ESC Heart Failure, Volume 12, Issue 2, Page 1374-1385, April 2025.
Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu, Gui‐Qin Liu, Ya‐Ping Peng, Li‐Ling Zhang, Xian‐Jin Wang, Liang‐Chuan Chen, Yuan‐Xi Zheng, Xue‐Jun Xiang, Rui Qiao, Xian‐He Lin   +9 more
wiley   +1 more source