Results 141 to 150 of about 668,836 (354)

Skin microbiota: a source of disease or defence?

, 2008
Microbes found on the skin are usually regarded as pathogens, potential pathogens or innocuous symbiotic organisms. Advances in microbiology and immunology are revising our understanding of the molecular mechanisms of microbial virulence and the specific
Cogen, AL, Gallo, RL, Nizet, V
core   +1 more source

Designed Liquid Crystalline Nanoassemblies From Clinically Validated Polyunsaturated Lipids for Combined Antioxidant, Anti‐Apoptotic, and Neurotrophic Treatments

Advanced Healthcare Materials, EarlyView.
Ionizable lipid nanoparticles target multiple pathological pathways in neurodegeneration. The designed self‐assembled materials undergo a pH‐triggered structural transformation from a cubosome/hexosome coexistence to a hexosome phase, enhancing intracellular delivery of a multi‐target phytochemical formulation. The antioxidant‐loaded pH‐responsive LNPs
Thelma Akanchise, Fucen Luo, Borislav Angelov, Yuru Deng, Angelina Angelova   +4 more
wiley   +1 more source

Lack of Association between IL12B Gene Single Nucleotide Polymorphism (rs6887695G/C) and Chronic Hepatitis B Virus Infection in an Iranian Population

Journal of Mazandaran University of Medical Sciences, 2017
Background and purpose: Hepatitis B virus (HBV) is considered to be one of the most important etiological factors of liver complication around the world.
Sediqeh Heidarian, Farzaneh Sabahi, Seyed Reza Mohebbi, Maryam Karkhane, Pedram Azimzadeh, Mahsa Saeedi Niasar, Shaqaeyeq Derakhshani, Afsaneh Sharifian, Mohammadreza Zali   +8 more
doaj  

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Captopril and lisinopril suppress production of interleukin-12 by human peripheral blood mononuclear cells

, 1998
Cris S. Constantinescu, David B. P. Goodman, Elvira Ventura   +2 more
openalex   +1 more source

Engineering Resatorvid‐Loaded Sub‐Microgels of Epigallocatechin‐3‐gallate/Hyaluronic Acid to Treat Acute Lung Injury

Advanced Healthcare Materials, EarlyView.
This study presents HAEP@Res sub‐microgels as a lung‐targeted delivery system integrating antioxidant activity with anti‐inflammatory therapy. The sub‐microgels demonstrate excellent biocompatibility, efficiently scavenge intracellular ROS, and downregulate pro‐inflammatory cytokines and genes in a Bleo‐induced ALI mouse model. These findings highlight
Bo Liu, Olawale Alimi Alimi, Benjamin Stearnes, Svetlana Romanova, Brady J. Sillman, Mena Asha Krishnan, Kristina Bailey, Benson J. Edagwa, Huanhuan Joyce Chen, Han‐jun Wang, Bin Duan   +10 more
wiley   +1 more source

Gene Electrotransfer of Canine Interleukin 12 into Canine Melanoma Cell Lines

, 2015
Ursa Lampreht, Urška Kamenšek, Monika Stimac, Gregor Serša, Nataša Tozon, Maša Bošnjak, Andreja Brožič, Geraldo Gileno de Sá Oliveira, Takayuki Nakagawa, Kohei Saeki, Maja Čemažar   +10 more
openalex   +2 more sources

Localized Immunotherapy Delivery Using Injectable in situ Forming Chitosan Hydrogel [PDF]

, 2016
Cytokine-based cancer immunotherapies stimulate a host’s immune system to fight cancer. In particular, interleukin-12 (IL-12), a potent pro-inflammatory cytokine, has demonstrated the ability to eliminate tumors in a number of preclinical models ...
Washispack, Seth
core   +2 more sources

A Superhydrophobic 3D Cell Culture System Reveals the Mechanobiological Role of Cancer‐Associated Fibroblasts in Prostate Cancer Metastasis

Advanced Healthcare Materials, EarlyView.
A superhydrophobic 3D cell culture platform enables rapid and consistent formation of heterotypic tumor–stroma clusters, and reveals how physiological shear conditions influence metastatic signaling. Mechanical stimulation of cancer‐associated fibroblasts promotes sustained cytokine secretion and survival‐promoting pathways, showing how multicellular ...
Alexandria T. Carter, Abigail R. Fabiano, Ehsan Aalaei, Jason Deng, Dakota E. Rostant, Michael R. King   +5 more
wiley   +1 more source

Interleukin-12 inhibits hepatitis B virus replication in transgenic mice [PDF]

, 1997
Victoria J. Cavanaugh, Luca G. Guidotti, Francis V. Chisari   +2 more
openalex   +1 more source