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Human Immunology, 2005
The aim of this study was to assess the possible association between the IL12B and the IL12RB1 gene polymorphisms and the systemic autoimmune disease rheumatoid arthritis (RA). Our study population consisted of 545 patients with RA and 393 healthy subjects. All the individuals were of white Spanish origin. Genotyping of the IL12B (IL12Bpro and IL12B 3'
Orozco, Gisela +7 more
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The aim of this study was to assess the possible association between the IL12B and the IL12RB1 gene polymorphisms and the systemic autoimmune disease rheumatoid arthritis (RA). Our study population consisted of 545 patients with RA and 393 healthy subjects. All the individuals were of white Spanish origin. Genotyping of the IL12B (IL12Bpro and IL12B 3'
Orozco, Gisela +7 more
openaire +3 more sources
The interleukin‐12 subunit p40 specifically inhibits effects of the interleukin‐12 heterodimer
European Journal of Immunology, 1993AbstractThe recently discovered cytokine interleukin (IL)‐12 is a heterodimeric protein of two disulfide‐bonded subunits of 35 and 40 kDa. IL‐12 has multiple effects on T cells and natural killer (NK) cells. In particular it appears to be a major factor for the development of cellular immunity.
F, Mattner +7 more
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International Archives of Allergy and Immunology, 1995
Interleukin (IL)-12 was originally identified as a factor produced by human Epstein-Barr virus-transformed B cell lines. It was detected by one group as cytotoxic lymphocyte maturation factor, a cytokine that synergized with IL-2 in the induction of lymphokine-activated killer cells and cytotoxic T lymphocytes.
T, Germann, E, Rüde
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Interleukin (IL)-12 was originally identified as a factor produced by human Epstein-Barr virus-transformed B cell lines. It was detected by one group as cytotoxic lymphocyte maturation factor, a cytokine that synergized with IL-2 in the induction of lymphokine-activated killer cells and cytotoxic T lymphocytes.
T, Germann, E, Rüde
openaire +2 more sources
Interleukin 12 and autoimmune diabetes
Nature Genetics, 2001Interleukin 12 (IL-12) has been implicated in the pathogenesis of type 1 diabetes in the non-obese diabetic (NOD) mouse. Following this lead, a new locus associated with human type 1 diabetes, IDDM18, has been identified near the gene encoding the p40 subunit of interleukin 12 (IL12B).
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Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity
Cancer Cell, 2022Yared Hailemichael +2 more
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