Results 281 to 290 of about 6,238,612 (332)

Induction of IL-2 by interleukin-12 p40 homodimer and IL-12, but not IL-23, in microglia and macrophages: Implications for multiple sclerosis. [PDF]

Cytokine
Jana M, Mondal S, Jana A, Pahan K.
europepmc   +1 more source

Long-Term Follow-Up of Phase I Trial of Oncolytic Adenovirus-Mediated Cytotoxic and Interleukin-12 Gene Therapy for Treatment of Metastatic Pancreatic Cancer. [PDF]

Biomedicines
Bhatnagar AR, Siddiqui F, Khan G, Pompa R, Kwon D, Nyati S.   +5 more
europepmc   +1 more source

Systemic interleukin-12 displays antitumor activity in the mouse central nervous system [PDF]

キシマ, ハルヒコ, 貴島, 晴彦
core  

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Interleukin 12 and interleukin 23 play key pathogenic roles in inflammatory and proliferative pathways in giant cell arteritis

Annals of the Rheumatic Diseases, 2018
Objectives The pathogenesis of giant cell arteritis (GCA) remains unclear. TH1 and TH17 pathways are implicated, but the proximal initiators and effector cytokines are unknown.
R. Conway, L. O’neill, G. McCarthy, C. Murphy, A. Fabre, S. Kennedy, D. Veale, S. Wade, U. Fearon, E. Molloy   +9 more
semanticscholar   +1 more source

Interleukin-12

Journal of Leukocyte Biology, 1994
Abstract Interleukin-12 (IL-12) is a newly characterized cytokine that has a unique heterodimeric structure. It was initially cloned from B lymphoblastoid cell lines, but the majority of IL-12 is produced by macrophages/monocytes following appropriate stimulation. IL-12 can (1) enhance the cytolytic activity of a number of effector cells
openaire   +2 more sources

Immunoregulation by interleukin-12

Journal of Leukocyte Biology, 1996
Abstract Interleukin-12 (IL-12) is a heterodimeric cytokine produced primarily by antigen-presenting cells (monocytes, macrophages, dendritic cells, and B cells). Its production is stimulated by bacteria, bacterial products, and intracellular parasites and enhanced by priming with granulocyte-macrophage colony-stimulating factor (CM-CSF)
G, Trinchieri, F, Gerosa
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Interleukin-12

BioDrugs, 2003
Asthma is an inflammatory disease of the airways leading to significant morbidity and mortality. With advances in the understanding of the molecular and cellular mechanisms involved in the asthmatic response, researchers have identified specific mediators that may be targeted to control the inflammatory state of asthma. The Th2 hypothesis proposes that
Patricia, Leonard, Sanjiv, Sur
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Molecular characterization of interleukin 12

Archives of Biochemistry and Biophysics, 1992
Interleukin 12 (IL-12), formerly known as cytotoxic lymphocyte maturation factor and natural killer cell stimulatory factor, is a cytokine secreted by a human B lymphoblastoid (NC-37) cell line when induced in culture with phorbol ester and calcium ionophore. This factor has been purified to homogeneity and shown to synergize with low concentrations of
F J, Podlaski, V B, Nanduri, J D, Hulmes, Y C, Pan, W, Levin, W, Danho, R, Chizzonite, M K, Gately, A S, Stern   +8 more
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Interleukin 12 (IL12B) and Interleukin 12 Receptor (IL12RB1) Gene Polymorphisms in Rheumatoid Arthritis

Human Immunology, 2005
The aim of this study was to assess the possible association between the IL12B and the IL12RB1 gene polymorphisms and the systemic autoimmune disease rheumatoid arthritis (RA). Our study population consisted of 545 patients with RA and 393 healthy subjects. All the individuals were of white Spanish origin. Genotyping of the IL12B (IL12Bpro and IL12B 3'
Orozco, Gisela, González-Gay, Miguel A., Paco, Laura, López-Nevot, Miguel A., Guzmán, Manuel, Pascual-Salcedo, Dora, Balsa, Alejandro, Martín, Javier   +7 more
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