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The interleukin‐12 subunit p40 specifically inhibits effects of the interleukin‐12 heterodimer
European Journal of Immunology, 1993AbstractThe recently discovered cytokine interleukin (IL)‐12 is a heterodimeric protein of two disulfide‐bonded subunits of 35 and 40 kDa. IL‐12 has multiple effects on T cells and natural killer (NK) cells. In particular it appears to be a major factor for the development of cellular immunity.
F, Mattner +7 more
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International Archives of Allergy and Immunology, 1995
Interleukin (IL)-12 was originally identified as a factor produced by human Epstein-Barr virus-transformed B cell lines. It was detected by one group as cytotoxic lymphocyte maturation factor, a cytokine that synergized with IL-2 in the induction of lymphokine-activated killer cells and cytotoxic T lymphocytes.
T, Germann, E, Rüde
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Interleukin (IL)-12 was originally identified as a factor produced by human Epstein-Barr virus-transformed B cell lines. It was detected by one group as cytotoxic lymphocyte maturation factor, a cytokine that synergized with IL-2 in the induction of lymphokine-activated killer cells and cytotoxic T lymphocytes.
T, Germann, E, Rüde
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Novel strategies exploiting interleukin-12 in cancer immunotherapy.
Pharmacology and Therapeutics, 2022A. Cirella +12 more
semanticscholar +1 more source
Interleukin 12 and autoimmune diabetes
Nature Genetics, 2001Interleukin 12 (IL-12) has been implicated in the pathogenesis of type 1 diabetes in the non-obese diabetic (NOD) mouse. Following this lead, a new locus associated with human type 1 diabetes, IDDM18, has been identified near the gene encoding the p40 subunit of interleukin 12 (IL12B).
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Interleukin-12 and the regulation of innate resistance and adaptive immunity
Nature reviews. Immunology, 2003G. Trinchieri
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