Results 181 to 190 of about 583,184 (351)

Clinical Investigation of the Role of Interleukin-4 and Interleukin-13 in the Evolution of Prostate Cancer [PDF]

, 2011
Robert M. Goldstein, Charles Hanley, Jonathan C. Morris, Declan Cahill, Ashish Chandra, Peter Harper, Simon Chowdhury, John Maher, S. Burbridge   +8 more
openalex   +1 more source

Binding, Neutralization and Internalization of the Interleukin-13 Antibody, Lebrikizumab. [PDF]

Dermatol Ther (Heidelb), 2023
Okragly AJ, Ryuzoji A, Wulur I, Daniels M, Van Horn RD, Patel CN, Benschop RJ.   +6 more
europepmc   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

IL-13 Gene Polymorphisms and Their Association with Atopic Asthma and Rhinitis in Pakistani Patients

Iranian Journal of Allergy, Asthma and Immunology, 2013
Interleukin-13 (IL-13) is known to be a key regulator in immunoglobulin E (IgE) synthesis, mucus hypersecretion and airway hyperresponsiveness. Single nucleotide polymorphisms in IL-13 are associated with allergic phenotypes in several ethnically diverse
Micheal Shazia, Minhas Kanza, Ishaque Mehwish, Shabbir Irum, Ahmed Farida, Ahmed Asifa   +5 more
doaj  

From Macrophage Interleukin-13 Receptor to Foam Cell Formation [PDF]

, 2012
Valentin P. Yakubenko, Linda C. Hsi, Martha K. Cathcart, Ashish Bhattacharjee   +3 more
openalex   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Interleukin-13 maintains the stemness of conjunctival epithelial cell cultures prepared from human limbal explants

, 2019
Andrea Stadnikova, Peter Trošan, Pavlína Skalická, Tor Paaske Utheim, Kateřina Jirsová   +4 more
openalex   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Administration of mesenchymal stem cell derivate secretome causes lower levels of Matrix Metalloproteinase-13, Aggrecanase-2, and Interleukin-1β than hyaluronic acid in rabbit knee osteoarthritis

, 2023
Cokorda Gde Oka Dharmayuda, I Ketut Siki Kawiyana, I Made Bakta, I Nyoman Mantik Astawa, Putu Astawa, Ida Bagus Putra Manuaba, I Ketut Suyasa, Anak Agung Ngurah Subawa, Heri Suroto, Luh Putu lin Indrayani Maker   +9 more
openalex   +2 more sources