Results 311 to 320 of about 583,184 (351)
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Histopathology, 2001
Aims: Hodgkin's disease (HD) is characterized by the presence of Hodgkin and Reed–Sternberg (H–RS) cells against a hyperplastic background of reactive cells such as lymphocytes, histiocytes, plasma cells, eosinophils, neutrophils, and stromal cells.
K, Ohshima +5 more
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Aims: Hodgkin's disease (HD) is characterized by the presence of Hodgkin and Reed–Sternberg (H–RS) cells against a hyperplastic background of reactive cells such as lymphocytes, histiocytes, plasma cells, eosinophils, neutrophils, and stromal cells.
K, Ohshima +5 more
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Interleukin-13: Characterization and biologic properties
1995Upon activation by antigen, helper T cells respond by secreting factors, called cytokines, that coordinate the immune response. The type of T-cell response initiated depends upon the antigenic stimulus and can result in a polarization of the spectrum of cytokines secreted.
A N, McKenzie, G, Zurawski
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Blood, 2001
Hodgkin lymphoma (HL) is characterized by the abnormal expression of multiple cytokines, accounting for its unique clinicopathologic features. We have previously shown that interleukin-13 (IL-13) is secreted by HL cell lines and may serve as an autocrine growth factor. To determine the frequency of IL-13 expression in lymphoma patients, tissue sections
B F, Skinnider +8 more
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Hodgkin lymphoma (HL) is characterized by the abnormal expression of multiple cytokines, accounting for its unique clinicopathologic features. We have previously shown that interleukin-13 (IL-13) is secreted by HL cell lines and may serve as an autocrine growth factor. To determine the frequency of IL-13 expression in lymphoma patients, tissue sections
B F, Skinnider +8 more
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Interleukin 13: A Growth Factor in Hodgkin Lymphoma
International Archives of Allergy and Immunology, 2001Classical Hodgkin lymphoma (cHL) is a malignant disorder of lymph nodes with distinctive clinical and pathologic features. These features are thought to be primarily due to the abnormal production of multiple cytokines by the malignant cell population of HL, the Reed-Sternberg (RS) cells.
Skinnider, Brian F. +2 more
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Effects of interleukin-13 on human neutrophil functions
Journal of Leukocyte Biology, 1996Abstract It was recently shown that interleukin-13 (IL-13) induces the expression and release of the IL-1 decoy receptor (type II) in human neutrophils along with the production of the IL-1 receptor antagonist. In the present study we focused on further studying the modulatory effects of IL-13 on these cells.
D, Girard +3 more
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The role of interleukin‐13 in infectious diseases and allergy
BioEssays, 2000Cytokines, also referred to as interleukins, are the major orchestrators of host defence processes, and, as such, are involved in insults, repair and restoration of tissue homeostasis. This review summarises recent findings on and emerging models of the biological roles of the double-edged sword interleukin-13 (IL-13), which have been principally ...
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Interleukin 13 and Related Cytokines
1996The function of CD4-positive, T helper cells is pivotal to the workings of the specific immune system. These cells direct antibody responses to protein antigens and influence cellular immunity by activating macrophages and instigating delayed-type hypersensitivity reactions. T helper cells perform these functions partially through altered expression of
Andrew N. J. McKenzie, Andrew W. Heath
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1995
Abstract The mouse IL-13 cDNA (GenBank accession number M23504) encodes a protein of 131 amino acids (Brown eta/. 1989). The human IL-13 (hlL-13) cDNA (GenBank accession No L06801) encodes a protein of 132 amino acids (McKenzie et al. 1993a; Minty eta/. 1993).
A N J McKenzie, G Zurawski
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Abstract The mouse IL-13 cDNA (GenBank accession number M23504) encodes a protein of 131 amino acids (Brown eta/. 1989). The human IL-13 (hlL-13) cDNA (GenBank accession No L06801) encodes a protein of 132 amino acids (McKenzie et al. 1993a; Minty eta/. 1993).
A N J McKenzie, G Zurawski
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Interleukin-13 is a monocyte chemoattractant.
European cytokine network, 1995Recombinant human IL-13 is chemotactic for purified human peripheral blood monocytes Cell migration is stimulated with a typical bell-shaped concentration curve and is maximal at 10 ng/ml. Migration is the result of chemotaxis, and not chemokinesis, as shown by checkerboard experiments. The chemotactic activity of IL-13 on monocytes is not inhibited by
M, Magazin +3 more
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