Results 41 to 50 of about 3,870,583 (322)

Th2 Cytokines Increase the Expression of Fibroblast Growth Factor 21 in the Liver

Cells, 2021
Interleukin-4 (IL-4) and IL-13 are the major T helper 2 (Th2) cytokines, and they are involved in the regulation of metabolism in the adipose tissue. The liver contains diverse innate and adaptive immune cells, but it remains to be determined whether Th2
Seul-Gi Kang, Seong-Eun Lee, Min-Jeong Choi, Joon-Young Chang, Jung-Tae Kim, Ben-Yuan Zhang, Yea-Eun Kang, Ju-Hee Lee, Hyon-Seung Yi, Minho Shong   +9 more
doaj   +1 more source

Preeclampsia Susceptibility Assessment Based on Deep Learning Modeling and Single Nucleotide Polymorphism Analysis

Biomedicines, 2023
The early diagnosis of preeclampsia, a key outlook in improving pregnancy outcomes, still remains elusive. The present study aimed to examine the interleukin-13 and interleukin-4 pathway potential in the early detection of preeclampsia as well as the ...
Aida Saadaty, Sara Parhoudeh, Khalil Khashei Varnamkhasti, Mehdi Moghanibashi, Sirous Naeimi   +4 more
doaj   +1 more source

Interleukin‐4 and interleukin‐13 evoke scratching behaviour in mice

Experimental Dermatology, 2019
Persistent and relapsing itch commonly manifests in inflammatory skin disorders such as atopic dermatitis (AD). AD pathogenesis is driven by interleukin‐4 (IL‐4) and interleukin‐13 (IL‐13). Dupilumab, a monoclonal antibody blocking the action of IL‐4 and
M. Campion, Leila Smith, S. Gatault, C. Métais, Jörg Buddenkotte, M. Steinhoff   +5 more
semanticscholar   +1 more source

Rapid Enlargement of Vitiligo Vulgaris after Initiation of Dupilumab for Atopic Dermatitis: A Case Report

Acta Dermato-Venereologica, 2021
is missing (Short communication)
Shintaro Takeoka, Masahiro Kamata, Ikumi Yokoi, Aya Takehara, Yayoi Tada   +4 more
doaj   +1 more source

The Intriguing Role of Interleukin 13 in the Pathophysiology of Asthma

Frontiers in Pharmacology, 2019
Approximately 5–10% of asthmatic patients worldwide suffer from severe asthma. Experimental and clinical studies have demonstrated that IL-13 is an important cytokine in chronic airways inflammation.
G. Marone, F. Granata, V. Pucino, A. Pecoraro, E. Heffler, S. Loffredo, G. Scadding, G. Varricchi   +7 more
semanticscholar   +1 more source

Th17 Lymphocytes in Respiratory Syncytial Virus Infection

Viruses, 2013
Infection by respiratory syncytial virus (RSV) affects approximately 33 million infants annually worldwide and is a major cause of hospitalizations. Helper T lymphocytes (Th) play a central role in the immune response during such infections.
Rizgar A. Mageed, Ali S. Jawad, Mohammed Al-Bogami, Nasra Al-Adhoubi, Jonas Bystrom   +4 more
doaj   +1 more source

The major secreted protein of the whipworm parasite tethers to matrix and inhibits interleukin-13 function

Nature Communications, 2019
Infection by soil transmitted parasitic helminths, such as Trichuris spp, are ubiquitous in humans and animals but the mechanisms determining persistence of chronic infections are poorly understood. Here we show that p43, the single most abundant protein
A. Bancroft, C. Levy, T. Jowitt, K. Hayes, Seona Thompson, E. Mckenzie, Matthew D. Ball, Eamon Dubaissi, Aidan P. France, B. Bellina, Catherine Sharpe, Aleksandr Mironov, S. Brown, P. Cook, Andrew S. MacDonald, D. Thornton, R. Grencis   +16 more
semanticscholar   +1 more source

The interleukin-13 paradox in asthma: effective biology, ineffective biologicals

European Respiratory Journal, 2019
Interleukin-13 (IL-13) is a pleiotropic cytokine produced by type-2 helper T-cells (Th2), mast cells and basophils, and is thought to be involved in many of the features of asthma.
Parameswaran Nair, P. O'Byrne
semanticscholar   +1 more source

Anti-aminoacyl-tRNA synthetase-interacting multifunctional protein-1 antibody improves airway inflammation in mice with house dust mite induced asthma

World Allergy Organization Journal
Background: Several biologics have been developed and used to treat severe asthma. However, commercialized biologics have limitations in treating T2-low asthma because their main target is the T2 inflammation marker. Therefore, there is an unmet need for
Sung-Ryeol Kim, MD, Yun Jung Um, MSc, Sook In Chung, PhD, Kyoung Yong Jeong, PhD, Hye Jung Park, MD, Kyung Hee Park, MD, Jung-Won Park, MD, Sang Gyu Park, PhD, Jae-Hyun Lee, MD   +8 more
doaj   +1 more source

The gene encoding interleukin-13: a susceptibility locus for asthma and related traits

Respiratory Research, 2000
Asthma is a complex inflammatory disorder controlled by both genetic and environmental influences. Multiple genetic analyses have identified the T helper type 2 (Th2) cytokine gene cluster on chromosome 5q as a susceptibility locus for asthma.
Wills-Karp Marsha
doaj   +1 more source