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Th17 Lymphocytes in Respiratory Syncytial Virus Infection
Viruses, 2013 Infection by respiratory syncytial virus (RSV) affects approximately 33 million infants annually worldwide and is a major cause of hospitalizations. Helper T lymphocytes (Th) play a central role in the immune response during such infections.
Rizgar A. Mageed +4 more
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Acta Dermato-Venereologica, 2021 is missing (Short communication)
Shintaro Takeoka +4 more
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Interleukin-13 (IL-13) Pathway [PDF]
Science's STKE, 2005 Interleukin-13 (IL-13), like IL-4, is a cytokine produced by T H 2 type helper T cells in response to signaling through the T cell antigen receptor and by mast cells and basophils upon cross-linkage of the high-affinity receptor for immunoglobulin E (IgE). It is also produced by activated eosinophils.
Ann, Kelly-Welch +2 more
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Brazilian Journal of Infectious DiseasesThe initial encounter of Leishmania with its host's immune system is important in the outcome of infection. Previous studies have shown that PBMCs from healthy volunteers (HV) exposed to Leishmania differ in IFN-γ production.
Zirlane Castelo B Coêlho +7 more
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Interleukin-13 Is Unlucky for Allergy Sufferers [PDF]
Trends in Pharmacological Sciences, 2019 Anaphylaxis, a life-threatening allergic reaction, is dependent on high affinity allergen-specific IgE. Gowthaman et al. now show that a new interleukin (IL)-13-expressing T helper cell subset specifically promotes high-affinity IgE responses. The discovery of T follicular helper (Tfh)13 cells defines potential new targets for allergy therapies.
Xie, Markus M., Dent, Alexander L.
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World Allergy Organization JournalBackground: Several biologics have been developed and used to treat severe asthma. However, commercialized biologics have limitations in treating T2-low asthma because their main target is the T2 inflammation marker. Therefore, there is an unmet need for
Sung-Ryeol Kim, MD +8 more
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Interleukin‐13: prospects for new treatments [PDF]
Clinical & Experimental Allergy, 2009 SummaryIL‐13 is a T‐helper type 2 cytokine. Animal models have implicated IL‐13 as a critical cytokine in the development of asthma and chronic obstructive pulmonary disease (COPD). In vitro IL‐13 exerts important effects on both structural and inflammatory cells within the airway and has the capacity to drive the clinical features of airways disease ...
Brightling, CE, Saha, S, Hollins, F
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The gene encoding interleukin-13: a susceptibility locus for asthma and related traits
Respiratory Research, 2000 Asthma is a complex inflammatory disorder controlled by both genetic and environmental influences. Multiple genetic analyses have identified the T helper type 2 (Th2) cytokine gene cluster on chromosome 5q as a susceptibility locus for asthma.
Wills-Karp Marsha
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Journal of Research in Medical Sciences, 2020 Background: Sarcoidosis and tuberculosis (TB) are two granulomatous inflammatory diseases with several common symptoms. The aim of the present study was to compare the serum levels of biomarkers including interleukin-4 (IL-4) and IL-13, calcium (Ca ...
Atefeh Abedini +5 more
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FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source