Results 11 to 20 of about 5,344,313 (296)
Interleukin-13 Is Unlucky for Allergy Sufferers [PDF]
Trends in Pharmacological Sciences, 2019 Anaphylaxis, a life-threatening allergic reaction, is dependent on high affinity allergen-specific IgE. Gowthaman et al. now show that a new interleukin (IL)-13-expressing T helper cell subset specifically promotes high-affinity IgE responses. The discovery of T follicular helper (Tfh)13 cells defines potential new targets for allergy therapies.
Xie, Markus M., Dent, Alexander L.
openaire +3 more sources
Impact of angiotensin converting enzyme inhibition on post- coronary artery bypass interleukin 6 release [PDF]
, 2002 Background: Angiotensin 1 converting enzyme (ACE) inhibitors reduce morbidity and mortality after coronary artery bypass graft surgery (CABG). This benefit may result from an anti- inflammatory action.
Humphries, S.E. +5 more
core +8 more sources
Characterization of the Interaction between Interleukin-13 and Interleukin-13 Receptors [PDF]
Journal of Biological Chemistry, 2005 Interleukin-13 (IL-13) possesses two types of receptor: the heterodimer, composed of the IL-13Ralpha1 chain (IL-13Ralpha1) and the IL-4Ralpha chain (IL-4Ralpha), transducing the IL-13 signals; and the IL-13Ralpha2 chain (IL-13Ralpha2), acting as a nonsignaling "decoy" receptor.
Kazuhiko, Arima +8 more
openaire +2 more sources
Mutants of Interleukin 13 with Altered Reactivity toward Interleukin 13 Receptors [PDF]
Journal of Biological Chemistry, 1999 Interleukin 13 (IL13) belongs to a family of cytokines whose members exhibit structural homology, despite amino acid sequence dissimilarity. For example, while of limited sequence homology, IL13 and IL4 share a signaling receptor, IL13/4 receptor, on a variety of human normal cells. However, a subclass of IL4-independent IL13 receptors is overexpressed
J P, Thompson, W, Debinski
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IL-13R alpha 2 reverses the effects of IL-13 and IL-4 on bronchial reactivity and acetylcholine-induced Ca2+ signaling [PDF]
, 2007 Background: The interleukins IL-4 and IL-13 play a key role in the pathophysiology of asthma. The interleukin receptor IL-13R alpha 2 is believed to act as a decoy receptor, but until now, the functional significance of IL-13R alpha 2 remains vague ...
Kellner, Julia +6 more
core +1 more source
Neuroimmunology of the Interleukins 13 and 4 [PDF]
Brain Sciences, 2016 The cytokines interleukin 13 and 4 share a common heterodimeric receptor and are important modulators of peripheral allergic reactions. Produced primarily by T-helper type 2 lymphocytes, they are typically considered as anti-inflammatory cytokines because they can downregulate the synthesis of T-helper type 1 pro-inflammatory cytokines.
Simone Mori, Pamela Maher, Bruno Conti
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, 2003 Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses.
McInnes, I.B. +2 more
core +1 more source
Cytokine profile associated with human chronic schistosomiasis mansoni
Memorias do Instituto Oswaldo Cruz, 2004 This study objective was to evaluate the cytokines associated with early events of hepatic fibrosis in schistosomiasis mansoni. Hepatic fibrosis was classified by ultrasonography in 94 patients.
Andréa Magalhães +9 more
doaj +1 more source
Interleukin-4 receptor alpha gene variants and allergic disease
Respiratory Research, 2000 The interleukin-4 (IL-4) signalling cascade has been identified as a pathway potentially important in the development of asthma. Genetic variants within this signalling pathway might contribute to the risk of developing asthma in a given individual.
Hall Ian P
doaj +1 more source
BMC Pregnancy and Childbirth, 2023 Background Preeclampsia is the main cause of preterm parturition and maternal–fetal complications. T helper 1 and T helper 2 cytokines balance is a requirement in normal pregnancy and aberrant in this immunologic balance, play an important role in the ...
Sara Parhoudeh +5 more
doaj +1 more source