Results 1 to 10 of about 29,695 (266)
The biology of Stat4 and Stat6 [PDF]
Oncogene, 2000 IL-4 and IL-12 are cytokines that are important regulators of the proliferation, differentiation and functional capacity of lymphocytes. STATs (signal transducers and activators of transcription) are transcription factors that provide a direct link between the cytokine receptors and cytokine induced gene transcription.
Michael J Grusby
exaly +3 more sources
Kat5 deficiency in alveolar type II cells licenses STAT6-driven glycolytic reprogramming and pulmonary fibrosis [PDF]
Nature CommunicationsPulmonary fibrosis (PF) remains a lethal progressive disease with poorly defined molecular drivers. Epithelial dysfunction and metabolic reprogramming contribute to PF, but the mechanistic link between these processes remains unclear. Here, we identify a
Youjing Yang +7 more
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Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II [PDF]
EMBO Journal, 2002 STAT6 is a central mediator of IL-4-induced gene responses. STAT6-mediated transcription is depend ent on the C-terminal transcription activation domain (TAD), but the mechanisms by which STAT6 activates transcription are poorly understood. Here, we have identified the staphylococcal nuclease (SN)-like domain and tudor domain containing protein p100 as
Jie Yang +2 more
exaly +3 more sources
STAT6 and lung inflammation [PDF]
Jak-stat, 2013 Lung inflammation has many etiologies, including diseases of Th2-type immunity, such as asthma and anti-parasitic responses. Inflammatory diseases of the lung involve complex interactions among structural cells (airway epithelium, smooth muscle, and fibroblasts) and immune cells (B and T cells, macrophages, dendritic cells, and innate lymphoid cells ...
Taylor A Doherty, Hannah H Walford
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STAT6 is amplified in a subset of dedifferentiated liposarcoma [PDF]
Modern Pathology, 2014 A recurrent intrachromosomal rearrangement on chromosome 12q in solitary fibrous tumor leads to the formation of a NAB2-STAT6 fusion oncogene. As a result, nuclear expression of the cytoplasmic transcription factor STAT6 is found in solitary fibrous tumor and serves as a useful diagnostic marker.
Adrian Mariño-Enríquez
exaly +3 more sources
STAT6 Mediates Interleukin-4 Growth Inhibition in Human Breast Cancer Cells
Neoplasia, 2002 In addition to acting as a hematopoietic growth factor, interleukin-4 (IL-4) inhibits growth of some transformed cells in vitro and in vivo. In this study, we show that insulin receptor substrate (IRS)-1, IRS-2, and signal transducer and activator of ...
Barbara Christy, Douglas Yee
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Intracranial Solitary Fibrous Tumors With Glandular and Papillary Structures: A Case Report [PDF]
Clinical Case ReportsSolitary fibrous tumor (SFT) is a fibroblastic neoplasm with NAB2 and STAT6 gene fusion as well as STAT6 nuclear expression. Uncommon variants of intracranial SFTs, such as glandular and papillary structures, are extremely rare.
Tingting Xu, Shasha Zheng, Leiming Wang
doaj +2 more sources
Modulation of STAT6 signaling for hepatoprotection
Frontiers in PharmacologySignal transducer and activator of transcription (STAT) proteins are a family of seven transcription factors mediating various biological processes. STAT6 is classically known to regulate immune cell biology by transmitting signals from interleukin (IL ...
Emmanuel Somm +12 more
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Indian Journal of Pathology and Microbiology, 2023 Solitary fibrous tumor/hemangiopericytoma (SFT/HPC) is a rare primary central nervous system (CNS) tumor, included in the World Health Organization (WHO) 2016 classification.
Mohapatra Debahuti +3 more
doaj +1 more source
Skeletal Muscle, 2021 Background The signal transducer and activator of transcription 6 (STAT6) transcription factor plays a vitally important role in immune cells, where it is activated mainly by interleukin-4 (IL-4).
Mitsutoshi Kurosaka +4 more
doaj +1 more source