Results 1 to 10 of about 30,689 (278)

Kat5 deficiency in alveolar type II cells licenses STAT6-driven glycolytic reprogramming and pulmonary fibrosis [PDF]

Nature Communications
Pulmonary fibrosis (PF) remains a lethal progressive disease with poorly defined molecular drivers. Epithelial dysfunction and metabolic reprogramming contribute to PF, but the mechanistic link between these processes remains unclear. Here, we identify a
Youjing Yang, Yi Ling, Jianzhong Li, Qianmin Li, Yanmei Feng, Jun Xiao, Yu Ma, Shasha Tao   +7 more
doaj   +2 more sources

Clinical biochemical significance of STAT6, ERG, and miR-647 expression in prostate cancer: Associations with tumor aggressiveness and patient prognosis [PDF]

Journal of Medical Biochemistry
Background: Reliable molecular indicators that can facilitate early detection and prognosis prediction in prostate cancer are still insufficient. Although Transcription 6 (STAT6), ERG, and microRNA-647 (miR-647) have recently been recognized as key ...
Hong Xin, Zhao Lin, Wang Tian, Yang Xiaobing, Hao Changzhen   +4 more
doaj   +2 more sources

Intracranial Solitary Fibrous Tumors With Glandular and Papillary Structures: A Case Report [PDF]

Clinical Case Reports
Solitary fibrous tumor (SFT) is a fibroblastic neoplasm with NAB2 and STAT6 gene fusion as well as STAT6 nuclear expression. Uncommon variants of intracranial SFTs, such as glandular and papillary structures, are extremely rare.
Tingting Xu, Shasha Zheng, Leiming Wang
doaj   +2 more sources

Infantile (congenital) anaplastic intracranial solitary fibrous tumor/hemangiopericytoma—A case report with brief literature review

Indian Journal of Pathology and Microbiology, 2023
Solitary fibrous tumor/hemangiopericytoma (SFT/HPC) is a rare primary central nervous system (CNS) tumor, included in the World Health Organization (WHO) 2016 classification.
Mohapatra Debahuti, Lenka Anasuya, Deo R. Chandra, Das Prateek   +3 more
doaj   +1 more source

Recurrent malignant solitary fibrous tumor of the scalp: a case report and literature review [PDF]

Journal of Pathology and Translational Medicine, 2022
Solitary fibrous tumor (SFT) is a rare type of mesenchymal neoplasm that first was discovered in the pleura but can also affect the peritoneum, lungs, mediastinum, and skin.
Ahmed Rabie, Abdulkarim Hasan, Yasein Mohammed, Ayman Abdelmaksoud, Ali A. Rabaan   +4 more
doaj   +1 more source

Transcription factor signal transducer and activator of transcription 6 (STAT6) is an inhibitory factor for adult myogenesis

Skeletal Muscle, 2021
Background The signal transducer and activator of transcription 6 (STAT6) transcription factor plays a vitally important role in immune cells, where it is activated mainly by interleukin-4 (IL-4).
Mitsutoshi Kurosaka, Yuji Ogura, Shuichi Sato, Kazuhisa Kohda, Toshiya Funabashi   +4 more
doaj   +1 more source

STAT6 Upregulates NRP1 Expression in Endothelial Cells and Promotes Angiogenesis

Frontiers in Oncology, 2022
The role of signal transducer and activator of transcription 6 (STAT6) in tumor growth has been widely recognized. However, its effects on the regulation of angiogenesis remain unclear.
Peng Gao, Peng Gao, Guanghui Ren, Jiangjiu Liang, Ju Liu   +4 more
doaj   +1 more source

T-bet syndrome-associated bronchial asthma phenotype

Медицинская иммунология, 2020
We aimed to evaluate a significance of T-bet transcription factor in bronchial asthma (BA). A total of 102 patients with BA were examined. The control group was represented by healthy subjects (21 people).
L. N. Sorokina, V. N. Mineev, A. V. Eremeeva, M. A. Nyoma   +3 more
doaj   +1 more source

Jak2/STAT6/c-Myc pathway is vital to the pathogenicity of Philadelphia-positive acute lymphoblastic leukemia caused by P190BCR-ABL

Cell Communication and Signaling, 2023
Background The Philadelphia chromosome encodes the BCR-ABL fusion protein, which has two primary subtypes, P210 and P190. P210 and P190 cause Philadelphia-positive chronic myeloid leukemia (Ph+ CML) and Philadelphia-positive acute lymphoblastic leukemia (
Run Qin, Teng Wang, Wei He, Wei Wei, Suotian Liu, Miao Gao, Zhenglan Huang   +6 more
doaj   +1 more source

Design of New Polyaspartamide Copolymers for siRNA Delivery in Antiasthmatic Therapy

Pharmaceutics, 2020
Here, a novel protonable copolymer was realized for the production of polyplexes with a siRNA (inhibitor of STAT6 expression in asthma), with the aim of a pulmonary administration.
Emanuela Fabiola Craparo, Salvatore Emanuele Drago, Nicolò Mauro, Gaetano Giammona, Gennara Cavallaro   +4 more
doaj   +1 more source