Results 31 to 40 of about 30,689 (278)
Improvement of 5-fluorouracil chemosensitivity in colorectal cancer cells by siRNA-mediated silencing of STAT6 oncogene [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Colorectal cancer (CRC) remains a major health concern worldwide due to its high incidence, mortality rate, and resistance to conventional treatments.
Omid Rahbar Farzam +8 more
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A Gain-of-function Mutation in STAT6 [PDF]
Journal of Biological Chemistry, 2000 Interleukin-4 (IL-4) is a cytokine that plays a crucial role in the pathophysiology of asthma and allergic diseases. IL-4-induced gene expression is largely mediated through the activation of the latent transcription factor STAT6. We identified a STAT6 mutant (STAT6VT)) that is activated independently of IL-4 stimulation. STAT6VT carries two amino acid
C, Daniel, A, Salvekar, U, Schindler
openaire +2 more sources
Oncotarget, 2014 Primary Mediastinal B-cell Lymphoma (PMBL) is a specific subtype of B-cell lymphoma which shares some phenotypic and genotypic features with diffuse large B-cell lymphoma (DLBCL) and with classical Hodgkin's lymphoma (HL). The genomic landscape of PMBL has not been fully elucidated, but has revealed the recurrent alteration of genes involved in JAK ...
Karen, Leroy +2 more
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Methylation of STAT6 Modulates STAT6 Phosphorylation, Nuclear Translocation, and DNA-Binding Activity [PDF]
The Journal of Immunology, 2004 Abstract Signal transducer and activator of transcription 6 is a transcription factor important for the development of Th2 cells and regulation of gene expression by IL-4 and IL-13. It has been reported that STAT1 activity is regulated by methylation of a conserved arginine residue in the N-terminal domain.
Weiguo, Chen +2 more
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Journal of Urological Surgery, 2023 A solitary fibrous tumor (SFT) originating from the prostate has been rarely reported, presenting the 44th case. We evaluated a 44-year-old man who presented with a two-year history of pressure in the lower abdomen. On magnetic resonance imaging, a 48×66
Hasan Yılmaz +4 more
doaj +1 more source
Frontiers in Immunology, 2019 Emerging evidence shows that signal transducer and activator of transcription 6 (STAT6) plays critical roles in tumor development. We previously found high-level expression of STAT6 in human lung adenocarcinoma and squamous cell carcinoma, specifically ...
Cuiping Fu +7 more
doaj +1 more source
Haematologica, 2009 Understanding the mechanisms behind malarial anemia should lead to new approaches to the management and treatment of children. In this perspective article Drs. Robson and Weatherall examine the pathophysiology of this condition. See related article on page 195.
Robson, K, Weatherall, D
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STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization
iScience, 2022 Summary: Although it is reported that mitochondria-localized nuclear transcription factors (TFs) regulate mitochondrial processes such as apoptosis and mitochondrial transcription/respiration, the functions and mechanisms of mitochondrial dynamics ...
Hyunmi Kim, Soo Jung Park, Ilo Jou
doaj +1 more source
Association analysis of STAT6 SNP with asthma in Pakistani population
Pakistan Journal of Pharmaceutical Sciences, 2021 Signal transducer and activator of transcription 6 gene (STAT6) is an important player of inflammatory pathways. The role of single nucleotide polymorphisms (SNPs) of STAT6 to the risk of asthma or IgE has been studied in several populations. We examined
Ayesha Riaz +4 more
doaj +1 more source
STAT6 - regulierte B-Zell-Antworten [PDF]
, 2022 IL-4 engagement of IL-4R type I results in tyrosine phosphorylation of janus kinase (JAK) 1 and 3. Activated JAKs phosphorylate STAT6, which dimerizes and translocates to the nucleus of B cells to regulate target gene expression important for IgE class ...
Mokada-Gopal, Lavanya
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