Results 31 to 40 of about 29,695 (266)

A rare case of a solitary fibrous tumor of vulva, displaying NAB2ex6-STAT6ex17 fusion

Indian Journal of Pathology and Microbiology, 2021
A solitary fibrous tumor (SFT), although ubiquitous, is rarely documented in the female genital tract, especially confirmed by STAT6 immunostaining and underlying NAB2-STAT6 gene fusion.
Bharat Rekhi, Prachi Bapat, Arpita Jindal   +2 more
doaj   +1 more source

IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics [PDF]

, 2016
Systemic sclerosis is an autoimmune connective tissue disease in which T cells play a prominent role. We and others have previously demonstrated a role for T cell-derived IL-13 in mediating the induction of collagen in dermal fibroblasts and that ...
van Laar, Jacob, Van Laar, Jacob M., O'Reilly, Steven, Fullard, Nicola, Ciechomska, Marzena, Przyborski, Stefan, van Laar, J.M., O’Reilly, S., Fullard, N., Przyborski, S., Ciechomska, M.   +10 more
core   +2 more sources

Solitary fibrous tumor/hemangiopericytoma of the external auditory canal

Acta Oto-Laryngologica Case Reports, 2019
Introduction: Solitary fibrous tumor/hemangiopericytoma is an uncommon neoplasm that accounts for only 1–2% of all soft tissue tumors. To the best of our knowledge only three cases of this tumor have been described in the external auditory canal in the ...
Jefferson Rijo-Cedeño, Luz Martín-Figueiro, Harold Tavárez, Rafael Ramírez-Camacho   +3 more
doaj   +1 more source

Activation of the IL-4/STAT6 Signaling Pathway Promotes Lung Cancer Progression by Increasing M2 Myeloid Cells

Frontiers in Immunology, 2019
Emerging evidence shows that signal transducer and activator of transcription 6 (STAT6) plays critical roles in tumor development. We previously found high-level expression of STAT6 in human lung adenocarcinoma and squamous cell carcinoma, specifically ...
Cuiping Fu, Liyan Jiang, Shengyu Hao, Zilong Liu, Suling Ding, Weiwei Zhang, Xiangdong Yang, Shanqun Li   +7 more
doaj   +1 more source

A Gain-of-function Mutation in STAT6 [PDF]

Journal of Biological Chemistry, 2000
Interleukin-4 (IL-4) is a cytokine that plays a crucial role in the pathophysiology of asthma and allergic diseases. IL-4-induced gene expression is largely mediated through the activation of the latent transcription factor STAT6. We identified a STAT6 mutant (STAT6VT)) that is activated independently of IL-4 stimulation. STAT6VT carries two amino acid
C, Daniel, A, Salvekar, U, Schindler
openaire   +2 more sources

Clinical biochemical significance of STAT6, ERG, and miR-647 expression in prostate cancer: Associations with tumor aggressiveness and patient prognosis [PDF]

Journal of Medical Biochemistry
Background: Reliable molecular indicators that can facilitate early detection and prognosis prediction in prostate cancer are still insufficient. Although Transcription 6 (STAT6), ERG, and microRNA-647 (miR-647) have recently been recognized as key ...
Hong Xin, Zhao Lin, Wang Tian, Yang Xiaobing, Hao Changzhen   +4 more
doaj   +1 more source

Functional expression of STAT6 in macrophages of the Mac-STAT6 mouse.

, 2023
Bone marrow derived macrophages (BMDM, purity >95%) were generated and splenic B cells (purity > 90%) isolated from mice that do express STAT6 only under control of the LysMCre promoter (Mac-STAT6), STAT6 knockout mice (STAT6ko) and BALB/c wild-type (WT)
Daniel Radtke (6190244), David Voehringer (713702), Kirstin Castiglione (15188308), Stefanie Westermann (15188305), Christoph Schubart (441046), Axel Dietschmann (4103692)   +5 more
core   +1 more source

Improvement of 5-fluorouracil chemosensitivity in colorectal cancer cells by siRNA-mediated silencing of STAT6 oncogene [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Colorectal cancer (CRC) remains a major health concern worldwide due to its high incidence, mortality rate, and resistance to conventional treatments.
Omid Rahbar Farzam, Behzad Baradaran, Bahman Akbari, Soozan Najafi, Mohammad Amini, AmirHossein Yari, Reza Dabbaghipour, Vahid Pourabdollah Kaleybar Pourabdollah Kaleybar, Shiva Ahdi Khosroshahi   +8 more
doaj   +1 more source

Targeting STAT6 in PMBL

Oncotarget, 2014
Primary Mediastinal B-cell Lymphoma (PMBL) is a specific subtype of B-cell lymphoma which shares some phenotypic and genotypic features with diffuse large B-cell lymphoma (DLBCL) and with classical Hodgkin's lymphoma (HL). The genomic landscape of PMBL has not been fully elucidated, but has revealed the recurrent alteration of genes involved in JAK ...
Karen, Leroy, Anais, Pujals, Laura, Pelletier   +2 more
openaire   +2 more sources

Methylation of STAT6 Modulates STAT6 Phosphorylation, Nuclear Translocation, and DNA-Binding Activity [PDF]

The Journal of Immunology, 2004
Abstract Signal transducer and activator of transcription 6 is a transcription factor important for the development of Th2 cells and regulation of gene expression by IL-4 and IL-13. It has been reported that STAT1 activity is regulated by methylation of a conserved arginine residue in the N-terminal domain.
Weiguo, Chen, Michael O, Daines, Gurjit K Khurana, Hershey   +2 more
openaire   +2 more sources