Cell Death and DiseaseCompelling evidence has revealed a novel function of the STAT pathway in the pathophysiology of uveal melanoma (UM); however, its regulatory mechanisms remain unclear.
Bo Liu +7 more
doaj +2 more sources
STAT6 EXPRESSION BY PERIPHERAL BLOOD LYMPHOCYTES IN BRONCHIAL ASTHMA [PDF]
Медицинская иммунология, 2014 . The aim of present study was to determine the features of STAT6 and phospho-STAT6 (pSTAT6) expression in bronchial asthma (BA). Patients and methods.
V. N. Mineev, L. N. Sorokina
doaj +2 more sources
GM-CSF Promotes Neutrophil PD-L1 Expression Through the VEGFR-2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma. [PDF]
Adv Sci (Weinh)VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Zhu F +13 more
europepmc +2 more sources
Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium-Dependent ANXA2<sup>+</sup>sEVs Driving M2 Polarization of TAMs. [PDF]
Adv Sci (Weinh)SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Fang Y +18 more
europepmc +2 more sources
Recurrent malignant solitary fibrous tumor of the scalp: a case report and literature review [PDF]
Journal of Pathology and Translational Medicine, 2022 Solitary fibrous tumor (SFT) is a rare type of mesenchymal neoplasm that first was discovered in the pleura but can also affect the peritoneum, lungs, mediastinum, and skin.
Ahmed Rabie +4 more
doaj +1 more source
STAT6 Upregulates NRP1 Expression in Endothelial Cells and Promotes Angiogenesis
Frontiers in Oncology, 2022 The role of signal transducer and activator of transcription 6 (STAT6) in tumor growth has been widely recognized. However, its effects on the regulation of angiogenesis remain unclear.
Peng Gao +4 more
doaj +1 more source
Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants. [PDF]
Adv Sci (Weinh)Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Huang R +14 more
europepmc +2 more sources
Transcriptional regulation by STAT6 [PDF]
Immunologic Research, 2011 Signal transducer and activator of transcription (STAT) proteins are critical mediators of cytokine signaling. Among the seven STAT proteins, STAT6 is activated by IL-4 and IL-13 and plays a predominant role in the immune system. However, there is increasing evidence that STAT6 may function in other tissues and organ systems.
Shreevrat, Goenka, Mark H, Kaplan
openaire +2 more sources
T-bet syndrome-associated bronchial asthma phenotype
Медицинская иммунология, 2020 We aimed to evaluate a significance of T-bet transcription factor in bronchial asthma (BA). A total of 102 patients with BA were examined. The control group was represented by healthy subjects (21 people).
L. N. Sorokina +3 more
doaj +1 more source
Expression of STAT6 and Phosphorylated STAT6 in Primary Central Nervous System Lymphomas
Journal of Neuropathology & Experimental Neurology, 2021 Abstract The signal transducer and activator of transcription 6 (STAT6) is implicated in the pathogenesis of some lymphomas including primary central nervous system lymphomas (PCNSLs). The aim of this study was to investigate STAT6 expression and clinicopathologic features in 25 PCNSLs using immunohistochemistry with 2 different anti ...
Georgia Karpathiou +7 more
openaire +2 more sources