Results 11 to 20 of about 30,689 (278)
EFFECTS OF IL-4 UPON THE ACTIVITY OF STAT6 TRANSCRIPTION FACTOR IN PERIPHERAL BLOOD LYMPHOCYTES IN BRONCHIAL ASTHMA [PDF]
Медицинская иммунология, 2014 . The aim of the study is to specify the levels of STAT6, and phospho-STAT6 under the influence of IL-4 in patients with bronchial asthma (BA). The samples from ten healthy controls and thirty-three BA patients with allergic and non-allergic clinical ...
V. N. Mineev +2 more
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STAT6 EXPRESSION BY PERIPHERAL BLOOD LYMPHOCYTES IN BRONCHIAL ASTHMA [PDF]
Медицинская иммунология, 2014 . The aim of present study was to determine the features of STAT6 and phospho-STAT6 (pSTAT6) expression in bronchial asthma (BA). Patients and methods.
V. N. Mineev, L. N. Sorokina
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Engineering IL-4 resistant proinflammatory human myeloid cells for cancer immunotherapy. [PDF]
Mol OncolWe developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Barberi T, Friedman AD.
europepmc +2 more sources
Modulation of STAT6 signaling for hepatoprotection
Frontiers in PharmacologySignal transducer and activator of transcription (STAT) proteins are a family of seven transcription factors mediating various biological processes. STAT6 is classically known to regulate immune cell biology by transmitting signals from interleukin (IL ...
Emmanuel Somm +12 more
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Cell Death and DiseaseCompelling evidence has revealed a novel function of the STAT pathway in the pathophysiology of uveal melanoma (UM); however, its regulatory mechanisms remain unclear.
Bo Liu +7 more
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STAT6 and lung inflammation [PDF]
JAK-STAT, 2013 Lung inflammation has many etiologies, including diseases of Th2-type immunity, such as asthma and anti-parasitic responses. Inflammatory diseases of the lung involve complex interactions among structural cells (airway epithelium, smooth muscle, and fibroblasts) and immune cells (B and T cells, macrophages, dendritic cells, and innate lymphoid cells ...
Walford, Hannah H, Doherty, Taylor A
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Transcriptional regulation by STAT6 [PDF]
Immunologic Research, 2011 Signal transducer and activator of transcription (STAT) proteins are critical mediators of cytokine signaling. Among the seven STAT proteins, STAT6 is activated by IL-4 and IL-13 and plays a predominant role in the immune system. However, there is increasing evidence that STAT6 may function in other tissues and organ systems.
Shreevrat, Goenka, Mark H, Kaplan
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Expression of STAT6 and Phosphorylated STAT6 in Primary Central Nervous System Lymphomas
Journal of Neuropathology & Experimental Neurology, 2021 Abstract The signal transducer and activator of transcription 6 (STAT6) is implicated in the pathogenesis of some lymphomas including primary central nervous system lymphomas (PCNSLs). The aim of this study was to investigate STAT6 expression and clinicopathologic features in 25 PCNSLs using immunohistochemistry with 2 different anti ...
Georgia Karpathiou +7 more
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Clinical and molecular implications of NAB2-STAT6 fusion variants in solitary fibrous tumour [PDF]
, 2021 Solitary fibrous tumour (SFT) is a mesenchymal neoplasm characterised by pathognomonic NAB2-STAT6 gene fusions. The clinical implications and prognostic value of different fusion variants has not been clarified.
Sharma, Nitin +15 more
core +1 more source
Nuclear Localization and Cleavage of STAT6 Is Induced by Kaposi's Sarcoma-Associated Herpesvirus for Viral Latency. [PDF]
PLoS Pathogens, 2017 Emerging evidence implies that STAT6 plays an important role in both the adaptive and innate immune responses to virus infection. Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic γ-herpesvirus agent associated with several human ...
Chong Wang +12 more
doaj +1 more source